公开(公告)号：EP1286705A2

公开(公告)日：2003-03-05

申请号：EP01941750.0

申请日：2001-05-31

Applicant: THE BOARD OF REGENTS OF OKLAHOMA STATE UNIVERSITY

Inventor： KOTOV, Nicholas, A.

IPC: A61K51/12 ,  A61K47/48

CPC classification number: B82Y5/00 ,  A61K47/6923 ,  A61K51/1244 ,  G02B2006/12195

Abstract: A bioconjugate including a nonoparticle covatently linked to a biological vector molecule. The nanoparticle is a generally radiocative metal ion and most typically a metal oxide. The biological vector molecule is typically a monoclonal antibody or fragment of a monoclonal antibody or a peptide having a known affinity to cancer cells. One or more additional, different biological moieties may be covalently linked to the nanoparticle in addition to the biological moieties may be covalently activity. The bioconjugate of the present invention has utility as an effective radiopharmaceutical to deliver a radiolabel in tumor treatment.