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公开(公告)号：WO2018191405A1
公开(公告)日：2018-10-18
申请号：PCT/US2018/027150
申请日：2018-04-11
Inventor： AMER, Momen Mohsen Ahmed , RAMSEY, Joshua, D.
Abstract: A multi-chamber single-use bioreactor for cell culture expansion has bag assembly and a rigid support structure defining a bag receiving space. The bag assembly disposed in the bag receiving space of the rigid support structure and supported by the rigid support structure. The bag assembly has at least a first flexible bag and a second flexible bag. The first bag defines a first reaction chamber, and the second bag defines a second reaction chamber. The first reaction chamber has a first volume, a first inlet, and a first outlet, and the second reaction chamber has a second volume different from the first volume, a second inlet, and a second outlet. The second inlet of the second bag is fluidically connected to the first outlet of the first bag so liquid in first reaction chamber can be transferred to the second reaction chamber.
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2.发明申请
公开(公告)号：WO2018191487A1
公开(公告)日：2018-10-18
申请号：PCT/US2018/027285
申请日：2018-04-12
Inventor： ATIYEH, Hasan K.
Abstract: Biocatalytic conversion systems and methods of producing and using same that have improved yields are disclosed. The systems and methods involve co-fermentation of sugars and gaseous substrates for alcohol, ketone, and/or organic acid production. The systems and methods may include biocatalytically converting at least one sugar substrate into at least one of alcohol, at least one ketone, and/or at least one organic acid. The systems and methods may further include biocatalytically converting gases that comprise CO 2 and H 2 to at least one alcohol and/or at least one organic acid, thereby adding extra revenue to biorefineries.
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3.发明申请COMPOSITION AND METHOD FOR TREATING HYPERGLYCEMIA UTILIZING AN EXTRACT OF POLYGONUM MULTIFLORUM 审中-公开使用多金属萃取物治疗高血压的组合物和方法
公开(公告)号：WO1995030427A1
公开(公告)日：1995-11-16
申请号：PCT/US1995005459
申请日：1995-05-03
Inventor： THE BOARD OF REGENTS OF OKLAHOMA STATE UNIVERSITY , CHENG, Nan-Zheng , STOECKER, Barbara, J.
IPC: A61K35/78
CPC classification number: A61K36/70 , Y10S514/866
Abstract: A composition and method for treating hyperglycemia which utilize an extract of the Chinese herb Polygonum multiflorum. The herb is extracted with 0.1 N NH4OH and centrifuged. The supernatant is applied to a Sephadex G-25 column. Three fractions are collected. The fractions exhibit a high insulin potentiating activity in fat cell assays and are shown to lower blood glucose levels.
Abstract translation: 一种治疗高血糖症的组合物和方法，其利用中草药枸杞提取物。 草本植物用0.1N NH4OH提取，离心。 将上清液施加到Sephadex G-25柱上。 收集三个分数。 这些级分在脂肪细胞测定中显示出高的胰岛素增强活性，并且显示降低血糖水平。
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4.发明申请SALTS OF 3-AZABICYCLO[3.3.1]NONANES AS ANTIARRHYTHMIC AGENTS, AND PRECURSORS THEREOF 审中-公开3-AZABICYCLO [3.3.1]作为抗坏血酸剂及其前体的不锈钢
公开(公告)号：WO1991007405A1
公开(公告)日：1991-05-30
申请号：PCT/US1990006625
申请日：1990-11-13
Inventor： THE BOARD OF REGENTS OF OKLAHOMA STATE UNIVERSITY , BERLIN, Kenneth, Darrell , SCHERLAG, Benjamin, Jacob , CLARKE, Cyril, Roy , OTIV, Surendra, Kamchandra , ZISMAN, Stan, Alan , SANGIAH, Subbiah , MULEKAR, Satish, Vasant
IPC: C07D471/08
CPC classification number: C07D221/22 , C07D471/08 , C07D495/08
Abstract: Salts of 3-azabicyclo[3.3.1]nonanes are used in controlling antiarrhythmic processes and precursors thereof are disclosed.
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5.发明公开Protective antigenes and vaccines for the control of multi species tick infestations 审中-公开Schutzantigene und Impfstoffe zur Kontrolle von multispecies Zeckenbefall
公开(公告)号：EP1655306A1
公开(公告)日：2006-05-10
申请号：EP05256580.1
申请日：2005-10-24
Inventor： De la Fuente, Jose de Jesus , Kocan, Katherine M. , Garcia-Almazan, Consuelo , Blouin, F. Edmour
IPC: C07K14/435 , A61K39/38 , A61K48/00
CPC classification number: C07K14/43527 , A61K39/00 , A61K48/00
Abstract: Broad range protective antigens against tick infestations, gene sequences and encoded proteins for such antigens, related vaccines and methods useful to induce an immune response.
Abstract translation: 广泛的针对蜱感染的基因序列保护性抗原，用于此类抗原的基因序列和编码的蛋白质，可用于诱导免疫应答的相关疫苗和方法。
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Patent Agency Ranking6.发明公开CARNITINE SUPPLEMENTED DIET TO PREVENT SUDDEN DEATH SYNDROME IN BROILER BREEDER TYPE POULTRY 有权肉碱FEED附加防止家禽HÄHNCHENZÜCHTUNGSARTIGEM猝死
公开(公告)号：EP1143945A3
公开(公告)日：2002-09-11
申请号：EP00920562.6
申请日：2000-03-23
Inventor： TEETER, Robert, G. , VANHOOSER, Stanley, L. , OWEN, Kevin, Q.
CPC classification number: A61K31/105
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7.发明公开
公开(公告)号：EP0927366A1
公开(公告)日：1999-07-07
申请号：EP97938440.0
申请日：1997-08-19
Inventor： McKEEVER, Stephen, W., S. , AKSELROD, Mark, S. , MARKEY, Brian, G.
IPC: G01T1
Abstract: The optically stimulated luminescence generated from a luminescent material having a relatively long lifetime of luminescence is measured by using short pulses of laser light stimulation and detecting luminescence only between pulses of light stimulation and after a certain delay following the stimulation pulse.
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8.发明公开
公开(公告)号：EP1004037A1
公开(公告)日：2000-05-31
申请号：EP99927382.4
申请日：1999-06-09
Inventor： McKEEVER, Stephen, W., S. , AKSELROD, Mark, S.
Abstract: This invention relates generally to luminescence techniques for imaging radiation fields and, more specifically, to the use of experimental and mathematical methods to distinguish between dynamic irradiation and static - or other abnormal radiation - exposure conditions for applications in personnel and environmental radiation dosimetry, or related fields. In more particular, the instant invention provides a rapid and reliable method of detecting abnormal dosimeter exposure conditions over a wide dynamic range of radiation doses, while avoiding significant background interference and stimulation light leakage. Additionally, the preferred embodiment of the instant invention uses a pulsed and synchronized luminescence detection scheme. Further, this invention teaches a complete method and system for abnormal exposure detection - including the use of a luminescent thin powder layer, the use of a periodic radiation absorbing filter, the pulsed stimulation and synchronized luminescence detection scheme, and the method of analyzing and interpreting the recorded images. Finally, the system provides a means of mathematically characterizing an image as containing either a normal or abnormal exposure.
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9.发明公开Protective antigens and vaccines for the control of multi species tick infestations 审中-公开保护性抗原和疫苗来控制蜱侵染的多物种
公开(公告)号：EP1749835A2
公开(公告)日：2007-02-07
申请号：EP06254078.6
申请日：2006-08-03
Inventor： de la Fuente, Jose de Jesus , Kocan, Katherine M. , Garcia-Almazan, Consuelo , Blouin, Edmour F.
IPC: C07K14/435 , A61K39/38 , A61K48/00
CPC classification number: C07K14/43527 , A61K39/00 , A61K48/00
Abstract: Broad range protective antigens against tick infestations, gene sequences and encoded proteins for such antigens, related vaccines and methods useful to induce an immune response.
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10.发明公开CARNITINE SUPPLEMENTED DIET TO PREVENT SUDDEN DEATH SYNDROME IN BROILER BREEDER TYPE POULTRY 有权肉碱FEED附加防止家禽HÄHNCHENZÜCHTUNGSARTIGEM猝死
公开(公告)号：EP1143945A2
公开(公告)日：2001-10-17
申请号：EP00920562.6
申请日：2000-03-23
Inventor： TEETER, Robert, G. , VANHOOSER, Stanley, L. , OWEN, Kevin, Q.
IPC: A61K31/00
CPC classification number: A61K31/105
Abstract: An effective amount of carnitine is administered to broiler breeder type poultry to prevent sudden death syndrome. In the preferred embodiment, a carnitine supplemented diet is fed to broiler breeder type chickens in a feed composition during a period of time preceding peak egg production. The feed composition preferably contains between 5 and 1000 ppm of carnitine.
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