公开(公告)号：WO2004063386A2

公开(公告)日：2004-07-29

申请号：PCT/EP2004/000149

申请日：2004-01-09

Applicant: UNIVERSITY OF LIEGE ,  MELICA HB ,  GENTEC B.V. ,  ANDERSSON, Leif ,  ANDERSSON, Goran ,  GEORGES, Michel ,  BUYS, Nadine

Inventor： ANDERSSON, Leif ,  ANDERSSON, Goran ,  GEORGES, Michel ,  BUYS, Nadine

IPC: C12Q

CPC classification number: C12Q1/6876 ,  C12Q2600/124 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

Abstract: The invention relates to methods to select animals, such as mammals, in particularly domestic animals such as breeding animals or animals destined for slaughter for having desired genotypic or potential phenotypic properties, in particular related to muscle mass and/or fat deposition or, in the case of mammals, to teat number. The invention provides a method for selecting an animal for having desired genotypic or potential phenotypic properties comprising testing said animal, a parent of said animal or its progeny for the presence of a nucleic acid modification affecting the activity of an evolutionary conserved CpG island, located in intron 3 of an IGF2 gene and/or for the presence of a nucleic acid modification affecting binding of a nuclear factor to an IGF2 gene.

Abstract translation: 本发明涉及选择动物，例如哺乳动物，特别是家畜，例如用于屠宰的育种动物或动物具有期望的基因型或潜在的表型性质，特别是与肌肉质量和/或脂肪沉积有关的方法，或者在 哺乳动物的情况，奶头数。 本发明提供了一种用于选择具有所需基因型或潜在表型性质的动物的方法，包括测试所述动物，所述动物的亲本或其后代，存在影响进化保守CpG岛的活性的核酸修饰，位于 IGF2基因的内含子3和/或影响核因子与IGF2基因结合的核酸修饰的存在。

公开(公告)号：EP1991674A1

公开(公告)日：2008-11-19

申请号：EP07715881.4

申请日：2007-02-14

Applicant: Universiteit Leiden ,  University of Liege ,  Friedrich-Alexander-Universität Erlangen-Nürnberg

Inventor： RIGALI, Sebastien ,  TITGEMEYER, Mannfred Friedrich Bruno ,  VAN WEZEL, Gilles Philippus

IPC: C12N15/09

CPC classification number: C12N15/52 ,  C07K14/36 ,  C12N1/38

Abstract: The invention relates to the field of biochemistry, molecular biology and microbiology. More specific the invention relates to methods and means for metabolic engineering and improved product formation by a filamentous micro-organism or a low G+C gram-positive bacterium. The invention discloses that DasR and DasR binding sites play an important and universal role in the control of gene expression in micro-organisms Based on this finding, the invention provides multiple useful applications, such as a method for regulating the expression of a gene of interest, a method for controlling metabolism, a method for decreasing undesired expression and many more. Moreover, the invention also provides means that can be used to establish said methods: for example a micro-organism in which the DasR binding site in operable linkage with a particular gene has been modified to obtain increased or decreased expression of a protein (being a desired or undesired protein) encoded by said gene.

公开(公告)号：EP0879060B1

公开(公告)日：2008-03-26

申请号：EP97902334.8

申请日：1997-02-04

Applicant: SmithKline Beecham Biologicals S.A. ,  University of Liege

Inventor： RENTIER, Bernard, Centre Hosp. Univ. de Liège ,  SADZOT, Catherine, Centre Hosp. Univ. de Liège

IPC: A61K39/245 ,  C07K14/04

CPC classification number: C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/25 ,  C12N2710/16722 ,  C12N2710/16734

Abstract: The present invention relates to compositions for the treatment or prevention of Zoster of individuals infected with Varicella Zoster virus (VZV), and to the prevention and treatment of Varicella infections. The compositions of the invention comprise the protein encoded by VZV gene 63 or an immunologically active derivative thereof. The invention further relates to compositions containing DNA or RNA corresponding to VZV gene 63.

公开(公告)号：EP1636299A1

公开(公告)日：2006-03-22

申请号：EP04729099.4

申请日：2004-04-23

Applicant: University of Liege

Inventor： PAGNOULLE, Christophe ,  STASSIN, Fabrice ,  CHAPELLE, Gerard ,  JEROME, Robert

IPC: C08J9/00 ,  C08J9/10 ,  C08J9/12 ,  C08K3/34 ,  C08G77/445 ,  C01B33/44

CPC classification number: C08J9/0061 ,  C01B33/44 ,  C08G63/6952 ,  C08G2261/126 ,  C08J9/0066 ,  C08J9/102 ,  C08J9/122 ,  C08J2203/08 ,  C08J2367/02 ,  C08J2483/00 ,  C08K3/346 ,  C08K5/0033 ,  C08K5/19 ,  C08K9/04 ,  C08L67/00 ,  C08L67/04 ,  C08L83/10 ,  C08L87/005 ,  C08L2666/18 ,  C08L83/00 ,  C08L2666/02

Abstract: The invention relates to a method for preparing a biodegradable polyester foam involving: mixing polyester in the form of a molten mass with a nanocharge consisting of organomodified clay; dispersing the latter in the polyester molten mass, and; expanding this polyester foam obtained in such a manner in the presence of an expanding agent whereby forming the polyester foam having a homogeneous structure thanks to the addition of a siliconized surfactant to the molten mass.

公开(公告)号：EP1632489A1

公开(公告)日：2006-03-08

申请号：EP04077400.2

申请日：2004-08-24

Applicant: University of Liege

Inventor： Detry, Vanessa ,  Pirotte, Bernard ,  Counerotte, Stéphane ,  Frankenne, Francis ,  Noel, Agnés ,  Foidart, Jean-Michel

IPC: C07D403/04 ,  C07D403/14 ,  A61K31/515 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00

CPC classification number: C07D401/12 ,  C07D239/62 ,  C07D403/12

Abstract: New Pyrimidinetrione derivatives represented by formula I

wherein R1 and R2 are defined in the description, composition thereof, and methods of preparation are described.
The compounds are useful in the treatment of disease involving metalloproteinases

Abstract translation: 由式I worin R1和R2所表示的新嘧啶三酮衍生物在本说明书中，组成物所限定，和制备方法进行说明。 的化合物在疾病涉及金属蛋白酶的治疗有用

公开(公告)号：EP1629114A2

公开(公告)日：2006-03-01

申请号：EP04734272.0

申请日：2004-05-21

Applicant: Helsingin Yliopisto ,  University of Liege ,  CONSIGLIO NAZIONALE DELLE RICERCHE ,  CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： SIVONEN, Kaarina ,  RANTALA, Anne ,  ROUHIAINEN, Leo ,  FEWER, David ,  RAJANIEMI, Pirjo ,  WILMOTTE, Annick ,  BOUTTE, Christophe ,  GRUBISIC, Stana ,  BALTHASART, Pierre ,  DE BELLIS, Gianluca ,  RIZZI, Ermanno ,  FROSINI, Andrea ,  CASTIGLIONI, Bianca ,  VENTURA, Stefano ,  MUGNAI, Maria Angela

IPC: C12Q1/68

CPC classification number: C12Q1/6895 ,  C12Q1/689 ,  C12Q2600/154 ,  C12Q2600/156

Abstract: This invention is related to a method for detecting toxic and non-toxic cyanobacteria. The method comprises that nucleic acid from a biological sample is brought into contact with an oligonucleotide designed to be specific for particular regions of the mcyE gene, the mcyE in combination with mcyD, and with an oligonucleotide designed to be specific for 16SrDNA, and the presence or absence of toxic cyanobacteria is detected by a suitable molecular biology method. The invention is related also to oligonucleotides used in the method.

公开(公告)号：EP1432684A2

公开(公告)日：2004-06-30

申请号：EP02772326.1

申请日：2002-09-19

Applicant: University of Liege

Inventor： DELARGE, Jacques ,  PIROTTE, Bernard ,  DOGNE, Jean-Michel ,  de LEVAL, Xavier ,  JULEMONT, Fabien

IPC: C07D213/76 ,  C07D213/89

CPC classification number: C07D213/76 ,  C07D213/89

Abstract: New pyridinic sulfonamide derivatives represented by a general formula (I), wherein R1, represents a mono- or polyhalogenated Cl-12-alkyl or a mono- or poly-halogenated C3-8-cycloalkyl group. The method of production of such derivatives and their use as active therapeutic substance in the treatment of diseases such as inflammation, arthrosis, cancer, angiogenesis and asthma are also reported.

公开(公告)号：EP1316317A1

公开(公告)日：2003-06-04

申请号：EP01204646.2

申请日：2001-11-30

Applicant: University of Liege

Inventor： Delattre, Luc, Université de Liège ,  Henry de Hassonville,Sandrine, Université de Liège ,  Evrard, Brigitte, Université de Liège

IPC: A61K47/40 ,  A61P5/24

CPC classification number: B82Y5/00 ,  A61K8/63 ,  A61K8/738 ,  A61K9/0043 ,  A61K31/565 ,  A61K31/57 ,  A61K45/06 ,  A61K47/6951 ,  A61K2800/56 ,  A61Q5/00 ,  A61Q7/00 ,  A61K2300/00

Abstract: Association et procédé de préparation à base de cyprotérone et/ou d'un ester de celle-ci hydrosoluble, comprenant le mélange de cyprotérone et/ou d'ester de celle-ci avec au moins une cyclodextrine choisie dans le groupe : béta-cyclodextrine et ses dérivés, la gamma-cyclodextrine et ses dérivés et leurs mélanges.
Composition pharmaceutique comprenant cette association et ayant une activité antiandrogénique et/ou progestative ou
Composition pharmaceutique ayant une activité antiséborrhéique et/ou antialopécique.
Enfin, utilisation de cette association à base de cyprotérone et/ou d'un ester en combinaison ou non avec un oestrogène, dans la préparation d'un médicament pour le traitement de l'hyperandrogénie, de l'hirsutisme, de l'acné sévère et des troubles liés à la ménopause .
Utilisation de cette association dans la préparation d'un médicament dans le traitement de la séborrhée et/ou de l'alopécie androgénique.

Abstract translation: 基于环丙孕酮（CPT）一个新的关联（I）（即混合物和/或复合物，爱特别是配合物（I“））包括：CPT和/或它的选自β-选定酯（A）和一种或多种环糊精（CD） CD，γCD和它们的衍生物（B）。 所以独立权利要求中包括了：<？>（1）生产的复合物（I“），由：<？>（a）在（A）wässrige溶液与过量的搅拌（B） 直到（I“）在溶液中，过滤形成为回收的（I溶液”滤液）作为; （b）加入有机溶剂中的（A）的溶液（具体地一种或多种醇的，丙酮和多元醇：如丙二醇或甘油）以wässrige溶液与（B）并搅拌直至（I' ）形成（在溶剂蒸发），得到（I“）以液体形式在可任选; 或（C） '通过冻干或喷雾干燥的（I溶液以固体形式如得到）制备（Ⅰ）' 的（a）或（b）; 和（2）的药物组合物包含（I）。

公开(公告)号：EP1191370A1

公开(公告)日：2002-03-27

申请号：EP00203181.3

申请日：2000-09-14

Applicant: UNIVERSITY OF LIEGE

Inventor： Lemaire, Philippe, Dr., Universite de Liege ,  Scauflaire, Veronique, Universite de Liege

IPC: G02B6/22 ,  G02B6/16

CPC classification number: G02B6/03627 ,  G02B6/241 ,  G02B6/262 ,  G02B6/4402 ,  G02B6/4478

Abstract: A monomode optical fibre provided for transporting light having a wavelength λ with 480 ≤ λ ≤ 550 nm, said fibre comprising a core made of a first transparent dielectric material, having a first refractive index n c and a substantially circular cross-section with a radius dimension a, said fibre further comprising a first cladding coaxially applied on said core and made of a second transparent dielectric material having a second refractive index n m1 , wherein n m1 c , The values of n c and n m1 are chosen in such a manner that the numerical aperture is less than 0.1 and wherein said radius dimension a > 2 µm.

Abstract translation: 提供用于传输具有480≤λ≤550nm的波长λ的光的单模光纤，所述光纤包括由第一透明电介质材料制成的芯，具有第一折射率nc和具有半径尺寸的基本圆形的横截面 a，所述光纤还包括同轴施加在所述芯上并由具有第二折射率nm1的第二透明电介质材料制成的第一包层，其中nm1 小于0.1，其中所述半径尺寸a>2μm。

公开(公告)号：EP1141418A2

公开(公告)日：2001-10-10

申请号：EP99969219.7

申请日：1999-12-16

Applicant: University of Liege ,  Melica HB ,  Seghersgentec N.V.

Inventor： ANDERSSON, Leif ,  GEORGES, Michel ,  SPINCEMAILLE, Geert ,  NEZER, Carine, Danielle, Andree

IPC: C12Q1/68 ,  C07K14/65 ,  A01K67/02

CPC classification number: C12Q1/6876 ,  A01K2227/108 ,  A01K2267/02 ,  C12Q2600/124 ,  C12Q2600/156 ,  C12Q2600/172

Abstract: The invention relates to methods to select breeding animals or animals destined for slaughter for having desired genotypic or potential phenotypic properties, in particular related to muscle mass and/or fat deposition. The invention provides a method for selecting a pig for having desired genotypic or potential phenotypic properties comprising testing a sample from said pig for the presence of a quantitative trait locus (QTL) located at a Sus scrofa chromosome 2 mapping at position 2p1.7.