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    Temporary blood circulation assist device
    27.
    发明申请
    Temporary blood circulation assist device 失效
    临时血液循环辅助装置

    公开(公告)号：US20030135086A1

    公开(公告)日：2003-07-17

    申请号：US10300467

    申请日：2002-11-19

    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY

    Inventor： Kenneth Khaw ,  John K-J Li

    IPC: A61M001/12

    CPC classification number: A61M1/1024 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1034 ,  A61M1/122 ,  A61M1/125

    Abstract: An inflatable circulation assist device is disclosed consisting of an inflatable stator housing an impeller with inflatable blades of varying shapes and sizes. The invention is introduced into the patient percutaneously. The circulation assist device is a small pump packaged into a compact form that is attached to a long flexible driveshaft. The pump is inserted along a guidewire to a target location, and then the pump is inflated. The circulation assist device's exterior is designed to expand only so much as to closely fit whatever cardiovascular system element in which it is placed for operation. The vascular assist device can be expanded either by inflation with a fluid. The driveshaft, which connects to the circulation assist device's impeller and extends outside the patient's body, is rotated by an external motor. After the circulation assist device is no longer needed, it is collapsed into a compact form and removed from the patient percutaneously.

    Abstract translation: 公开了一种充气循环辅助装置，其包括可膨胀的定子，该可充气定子容纳具有不同形状和尺寸的可充气叶片的叶轮。 本发明经皮引入患者体内。 循环辅助装置是一种小型泵，其包装成紧凑的形式，其连接到长的柔性驱动轴上。 泵沿着导丝插入到目标位置，然后泵被充气。 循环辅助装置的外部设计成只能扩张，以便紧密地适合放置在其中的任何心血管系统元件。 血管辅助装置可以通过用流体膨胀来扩张。 连接到循环辅助装置的叶轮并延伸到患者身体外部的驱动轴由外部马达旋转。 在循环辅助装置不再需要之后，它被压缩成紧凑形式并经皮从病人身上取出。

    Bone Morphogenetic Protein-2 And Bone Morphogenetic Protein-4 In The Treatment And Diagnosis Of Cancer
    28.
    发明申请
    Bone Morphogenetic Protein-2 And Bone Morphogenetic Protein-4 In The Treatment And Diagnosis Of Cancer 审中-公开
    骨形态发生蛋白-2和骨形态发生蛋白-4在癌症的治疗和诊断中的应用

    公开(公告)号：US20030134790A1

    公开(公告)日：2003-07-17

    申请号：US10139814

    申请日：2002-05-02

    Applicant: University of Medicine and Dentistry of New Jersey

    Inventor： John Langenfeld

    IPC: A61K038/17 ,  A61K038/43

    CPC classification number: G01N33/574 ,  A61K38/18

    Abstract: The present invention pertains to the use of BMP-2 and/or BMP-4 as 1) targets for cancer treatment therapies and 2) means to diagnose cancer. The therapeutic component of this invention involves administering to a patient a composition that inhibits bone morphogenetic protein-2 activity and/or bone morphogenetic protein-4 activity. Such inhibition may be accomplished by ligands or antibodies that bind to BMP-2 and/or BMP-4 or receptors for BMP-2 and BMP-4. It may also be achieved by preventing the processing of pro-BMP-2 and/or pro-BMP-4, or blocking transcription or replication of BMP-2 DNA and/or BMP-4 DNA or translation of BMP-2 mRNA and/or BMP-4 mRNA. The diagnostic component of the invention involves measuring the BMP-2 and/or BMP-4 level(s) in biological samples from both a patient and a non-cancerous subject and comparing those levels. Elevated levels of BMP-2 and/or BMP-4 in the patient compared to the subject indicate cancer.

    Abstract translation: 本发明涉及使用BMP-2和/或BMP-4作为1）癌症治疗疗法的靶标和2）诊断癌症的手段。 本发明的治疗成分包括向患者施用抑制骨形态发生蛋白-2活性和/或骨形态发生蛋白-4活性的组合物。 这种抑制可以通过结合BMP-2和/或BMP-4或BMP-2和BMP-4的受体的配体或抗体来实现。 还可以通过预防原BMP-2和/或前BMP-4的处理或阻断BMP-2DNA和/或BMP-4 DNA的转录或复制或BMP-2mRNA和/ 或BMP-4mRNA。 本发明的诊断成分包括从患者和非癌症受试者测量生物样品中的BMP-2和/或BMP-4水平并比较这些水平。 与受试者相比，患者中BMP-2和/或BMP-4的水平升高表明是癌症。

    Gene conferring resistance to the antibacterial 4,5-dihydroxy-2-cyclopenten-1-one (DHCP), the protein encoded by same, and applications thereof
    29.
    发明申请
    Gene conferring resistance to the antibacterial 4,5-dihydroxy-2-cyclopenten-1-one (DHCP), the protein encoded by same, and applications thereof 审中-公开
    赋予抗细菌4,5-二羟基-2-环戊烯-1-酮（DHCP）的抗性基因，由其编码的蛋白质及其应用

    公开(公告)号：US20020143163A1

    公开(公告)日：2002-10-03

    申请号：US09805681

    申请日：2001-03-14

    Applicant: The University of Medicine and Dentistry of New Jersey

    Inventor： Sangita Phadtare ,  Kunitoshi Yamanaka ,  Ikunoshin Kato ,  Masayori Inouye

    IPC: C07H021/02 ,  C07H021/04 ,  C07K001/00 ,  C07K014/00 ,  C07K017/00

    CPC classification number: C07K14/245 ,  Y02A50/473

    Abstract: The invention relates to a gene, dep, which confers resistance to the antibacterial activity of 4,5-dihydroxy-2-cyclopenten-1-one (DHCP). The invention further relates to the putative protein encoded by dep, which is a hydrophobic, transmembrane efflux protein specific for DHCP. The invention further relates to plasmids containing the dep gene, and to bacterial cells expressing dep. Furthermore, the invention provides applications for use in conferring resistance to antibacterial activity in organisms. The dep gene can be used to identify compounds which inhibit the efflux activity responsible for the resistance to DHCP or to compounds which are functionally equivalent to DHCP.

    Abstract translation: 本发明涉及赋予对4,5-二羟基-2-环戊烯-1-酮（DHCP）抗菌活性的抗性的基因dep。 本发明还涉及由dep制备的推定蛋白质，其是特异于DHCP的疏水性跨膜外排蛋白。 本发明还涉及含有dep基因的质粒和表达dep基因的细菌细胞。 此外，本发明提供了用于赋予生物体中抗细菌活性抗性的应用。 dep基因可以用于鉴定抑制对DHCP的抵抗力的外排活性或与功能上等同于DHCP的化合物的化合物。

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