公开(公告)号：US20180344836A1

公开(公告)日：2018-12-06

申请号：US15779509

申请日：2016-11-24

Applicant: University of Saskatchewan

Inventor： Volker GERDTS ,  Brenda ALLAN ,  Jan VAN DEN HURK ,  Yan ZHOU ,  Alexander ZAKHARTCHOUK ,  Suresh TIKOO ,  Andrew POTTER

IPC: A61K39/12 ,  A61K39/39 ,  G01N33/569 ,  A61P31/12

CPC classification number: C07K16/10 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/575 ,  C12N2770/20022 ,  C12N2770/20034 ,  G01N33/56983 ,  G01N2333/17

Abstract: Immunogens, compositions and methods for treating, preventing and/or diagnosing PEDV infection in pigs are disclosed. The compositions and methods use inactivated or attenuated virus-containing vaccines, or subunit vaccines, including immunogens and mixtures of immunogens derived from PEDV isolates.

公开(公告)号：US20180153438A1

公开(公告)日：2018-06-07

申请号：US15579524

申请日：2016-06-03

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： Darryl ADAMKO ,  Anas EL-ANEED

IPC: A61B5/08 ,  G01N33/493 ,  G01N33/68 ,  G16H10/40

CPC classification number: A61B5/08 ,  G01N33/493 ,  G01N33/6893 ,  G01N2570/00 ,  G01N2800/122 ,  G16H10/40 ,  G16H20/10 ,  G16H50/20 ,  G16H50/70

Abstract: Described are methods and uses employing metabolomic data to diagnose an asthma disease state or a Chronic Obstructive Pulmonary Disease (COPD) state. Further described are methods of uses of employing metabolomic data to distinguish between asthma and COPD. In particular, urinary metabolomic profiles are employed to enable differential diagnosis of asthma and COPD.

公开(公告)号：US20170095527A1

公开(公告)日：2017-04-06

申请号：US15383223

申请日：2016-12-19

Applicant: University of Saskatchewan

Inventor： Bernard Laarveld ,  Andrew A. Olkowski ,  Martin Reaney

IPC: A61K38/12 ,  A23K20/10 ,  C07K1/14 ,  A23L33/105 ,  A61K36/55 ,  A61K9/00

CPC classification number: A61K38/12 ,  A23K20/10 ,  A23K20/147 ,  A23L33/105 ,  A23L33/18 ,  A23V2002/00 ,  A61K9/0056 ,  A61K36/55 ,  A61K2236/39 ,  C07K1/145

Abstract: The present application includes a method for improving human and animal health comprising administering an effective amount of a linus cyclopeptide (LCP) extract from flaxseed to a subject in need thereof. Also included are feeds, foodstuffs, functional food compositions, natural product compositions nutraceuticals and food additive compositions comprising an LCP extract from flaxseed.

公开(公告)号：US09359282B2

公开(公告)日：2016-06-07

申请号：US14255001

申请日：2014-04-17

Applicant: University of Saskatchewan

Inventor： Ildiko Badea ,  Ronald Verrall ,  Jackson M. Chitanda ,  Randeep Kaur ,  Saniya Alwani

IPC: A61K47/48 ,  A61K31/4172 ,  C12N15/113 ,  C07C59/68 ,  C07C255/41 ,  C07C59/52 ,  H01J49/00 ,  A61K31/196 ,  A61K48/00 ,  C01B31/06 ,  H01J49/16 ,  B82Y5/00

CPC classification number: C07C59/68 ,  A61K47/6929 ,  B82Y5/00 ,  C01B32/28 ,  C07B2200/11 ,  C07C255/41 ,  C07C2604/00 ,  H01J49/164 ,  Y10T428/2982 ,  Y10T436/143333

Abstract: The present application relates to functionalized nanodiamonds, to complexes comprising a functionalized nanodiamond reversibly bound to a nucleic acid and to compositions comprising such functionalized nanodiamonds and complexes. In particular, the functionalized nanodiamonds comprise at least one naturally occurring basic amino acid, or analogs or derivatives thereof, covalently linked to a nanodiamond. The present application also includes methods and uses of the complexes and compositions, for example for delivering a nucleic acid to a cell.

Abstract translation: 本申请涉及功能化纳米金刚石，包括可逆结合于核酸的功能化纳米二金刚石的复合物和包含这种官能化纳米金刚石和络合物的组合物。 特别地，官能化纳米金刚石包含共价连接到纳米金刚石的至少一种天然存在的碱性氨基酸或其类似物或衍生物。 本申请还包括复合物和组合物的方法和用途，例如将核酸递送至细胞。

公开(公告)号：US09333253B2

公开(公告)日：2016-05-10

申请号：US13943990

申请日：2013-07-17

Applicant: University of Saskatchewan ,  University of Guelph

Inventor： Susantha Gomis ,  Suresh Kumar Tikoo ,  Davor Ojkic

IPC: A61K39/235 ,  C12N7/00 ,  A61K39/12 ,  A61K39/00

CPC classification number: A61K39/235 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/542 ,  A61K2039/552 ,  A61K2039/55561 ,  A61K2039/55566 ,  C12N7/00 ,  C12N2710/10034 ,  C12N2710/10234 ,  C12N2710/10251

Abstract: A composition comprising an isolated fowl adenovirus (FAdV), wherein the FAdV is a strain selected from FAdV-2, FAdV-7, FAdv-8a, FAdV-8b, FAdV-8a/8b or FAdV-11 serotype strains; and a suitable carrier and methods for inducing protective immunity in a subject and/or its progeny.

公开(公告)号：US20150150921A1

公开(公告)日：2015-06-04

申请号：US14556624

申请日：2014-12-01

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： Vladimir Vujanovic

IPC: A61K36/062 ,  C07K14/37 ,  C12Q1/68 ,  A23K3/00 ,  A01N63/02 ,  C12R1/645 ,  A23L3/3571 ,  C12N1/14 ,  A01N63/00

CPC classification number: A61K36/062 ,  A01N63/00 ,  A01N63/02 ,  A01N63/04 ,  A23K30/00 ,  A23L3/3571 ,  C07K14/37 ,  C12N1/14 ,  C12Q1/6895 ,  C12Q2600/158 ,  C12R1/645

Abstract: The present disclosure relates to a novel ascomyceteous fungus, Sphaerodes mycoparasitica, for controlling plant fungal pathogens, disease symptoms, and mycotoxins in planta and ex planta. Uses, methods, compositions, sequences, and products are also disclosed herein.

Abstract translation: 本公开涉及一种用于控制植物真菌病原体，疾病症状和植物和外来植物中真菌毒素的新颖的子囊菌真菌Sphaerodes mycoparasasica。 本文还公开了用途，方法，组合物，序列和产物。

公开(公告)号：US20150087612A1

公开(公告)日：2015-03-26

申请号：US14394456

申请日：2013-04-11

Applicant: University of Saskatchewan

Inventor： Clarence Ronald Geyer ,  Yu Luo

IPC: A61K31/555 ,  A61K31/43 ,  A61K31/357 ,  A61K31/496 ,  A61K31/164 ,  A61K31/65 ,  A61K31/409 ,  A61K31/7036

CPC classification number: A61K31/555 ,  A61K31/164 ,  A61K31/357 ,  A61K31/409 ,  A61K31/43 ,  A61K31/496 ,  A61K31/65 ,  A61K31/7036 ,  Y02A50/473 ,  A61K2300/00

Abstract: Compounds having the general structural formula (I) wherein X can be any element or compound that can form a coordination complex with phthalocyanine and wherein R1; R2, R3 and R4 are independently anionic moieties, or (II) wherein R1; R2, R3 and R4 are independently anionic moieties, are useful in the potentiation of antibiotic activity, and/or in inhibiting or delaying the development of resistance to antibiotics. R1; R2, R3 and R4 may be —S03-. The compounds may be administered to a subject in conjunction with an antibiotic. The antibiotic may be an activator of the SOS response, and may be a DNA gyrase inhibitor or a topoisomerase inhibitor. Compositions and dosage forms comprising the compounds are provided.

Abstract translation: 具有一般结构式（I）的化合物，其中X可以是可以与酞菁形成配位络合物的任何元素或化合物，其中R 1; R2，R3和R4独立地是阴离子部分，或（II）其中R1; R2，R3和R4独立地是阴离子部分，可用于增强抗生素活性，和/或用于抑制或延缓抗生素耐药性的发展。 R1; R2，R3和R4可以是-SO3-。 化合物可以与抗生素结合施用于受试者。 抗生素可以是SOS反应的激活剂，并且可以是DNA促旋酶抑制剂或拓扑异构酶抑制剂。 提供了包含该化合物的组合物和剂型。

公开(公告)号：US20150004185A1

公开(公告)日：2015-01-01

申请号：US14265136

申请日：2014-04-29

Applicant: University of Saskatchewan

Inventor： Kristen Marciniuk ,  Ryan Taschuk ,  Scott Napper ,  Andrew Potter ,  Neil Cashman

IPC: C07K7/06 ,  C07K16/44 ,  G01N33/68 ,  C07K14/00

CPC classification number: C07K7/06 ,  A61K39/0007 ,  A61K2039/55566 ,  A61K2039/6037 ,  C07K14/001 ,  C07K14/285 ,  C07K14/47 ,  C07K16/18 ,  C07K16/44 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/40 ,  C12N2760/20134 ,  G01N33/6854 ,  G01N33/6896 ,  G01N2333/001 ,  G01N2800/24 ,  G01N2800/2828

Abstract: Prion peptides comprising prion epitopes and fusions thereof, that display enhanced immunogenicity are described. Also described are methods of treating and diagnosing prion disease.

Abstract translation: 描述了包含朊病毒表位和其融合物的朊病毒肽，其显示增强的免疫原性。 还描述了治疗和诊断朊病毒疾病的方法。

公开(公告)号：US20130116350A1

公开(公告)日：2013-05-09

申请号：US13667333

申请日：2012-11-02

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： Reza Abbaslou ,  Ajay Dalai

IPC: B01J23/887

CPC classification number: B01J23/8872 ,  B01J21/185 ,  B01J23/881 ,  B01J35/006 ,  B01J35/1019 ,  B01J35/1042 ,  B01J37/0201 ,  B01J37/0207 ,  B01J37/024 ,  B82Y30/00 ,  C10G2/332 ,  C10G2/341

Abstract: The present application includes iron catalysts promoted with Mo, K and optionally Cu on a multi-walled carbon nanotube (MWCNT) support for high molecular weight hydrocarbon synthesis from synthesis gas.

Abstract translation: 本申请包括在多壁碳纳米管（MWCNT）载体上用Mo，K和任选的Cu促进用于从合成气中进行高分子量烃合成的铁催化剂。

公开(公告)号：US12082847B2

公开(公告)日：2024-09-10

申请号：US17268892

申请日：2019-08-15

Applicant: University of Saskatchewan

Inventor： Geoffrey H. F. Johnston ,  Nima Ashjaee ,  James Duncan Johnston

IPC: A61B17/68 ,  A61F2/28

CPC classification number: A61B17/68 ,  A61F2/28

Abstract: Implants and methods for stabilizing bone fractures are provided. In one embodiment, the implants are spheres. In another embodiment, the implants are rods. The rods can be used to stabilize peripheral portions of a bone fracture. The rods can be shaped and configured to correspond to the shape of a region of bone against which the rod will be deployed. The rods can be provided with surface features for engaging adjacent rods and/or adjacent regions of bone to further stabilize the rods. The spheres can be inserted to fill a remaining volume of the fracture cavity. The implants can be made from orthobiologic materials.