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Patent Agency Ranking
公开(公告)号：US20150004185A1
公开(公告)日：2015-01-01
申请号：US14265136
申请日：2014-04-29
Applicant: University of Saskatchewan
Inventor： Kristen Marciniuk , Ryan Taschuk , Scott Napper , Andrew Potter , Neil Cashman
CPC classification number: C07K7/06 , A61K39/0007 , A61K2039/55566 , A61K2039/6037 , C07K14/001 , C07K14/285 , C07K14/47 , C07K16/18 , C07K16/44 , C07K2317/34 , C07K2319/00 , C07K2319/40 , C12N2760/20134 , G01N33/6854 , G01N33/6896 , G01N2333/001 , G01N2800/24 , G01N2800/2828
Abstract: Prion peptides comprising prion epitopes and fusions thereof, that display enhanced immunogenicity are described. Also described are methods of treating and diagnosing prion disease.
Abstract translation: 描述了包含朊病毒表位和其融合物的朊病毒肽，其显示增强的免疫原性。 还描述了治疗和诊断朊病毒疾病的方法。
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公开(公告)号：US20150313976A1
公开(公告)日：2015-11-05
申请号：US14709877
申请日：2015-05-12
Applicant: University of Saskatchewan
Inventor： Scott Napper , Peter Hedlin , Philip Griebel , Lorne Babiuk , Neil Cashman , Avijit Chakrabartty , Andrew Potter
CPC classification number: C07K14/47 , A61K39/0007 , A61K2039/6037 , C07K7/06 , C07K7/08 , C07K16/2872 , C07K2317/34 , G01N33/6893 , G01N33/6896 , G01N2333/705 , G01N2800/2828
Abstract: Prion peptides comprising prion epitopes and fusions thereof, that display enhanced immunogenicity are described. Also described are methods of treating and diagnosing prion disease.
Abstract translation: 描述了包含朊病毒表位和其融合物的朊病毒肽，其显示增强的免疫原性。 还描述了治疗和诊断朊病毒疾病的方法。
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公开(公告)号：US09809620B2
公开(公告)日：2017-11-07
申请号：US14265136
申请日：2014-04-29
Applicant: University of Saskatchewan
Inventor： Kristen Marciniuk , Ryan Taschuk , Scott Napper , Andrew Potter , Neil Cashman
IPC: A61K39/00 , C07K14/47 , C07K7/06 , C07K7/08 , C07K16/28 , C07K16/18 , C07K14/00 , C07K16/44 , G01N33/68 , C07K14/285
CPC classification number: C07K7/06 , A61K39/0007 , A61K2039/55566 , A61K2039/6037 , C07K14/001 , C07K14/285 , C07K14/47 , C07K16/18 , C07K16/44 , C07K2317/34 , C07K2319/00 , C07K2319/40 , C12N2760/20134 , G01N33/6854 , G01N33/6896 , G01N2333/001 , G01N2800/24 , G01N2800/2828
Abstract: Prion peptides comprising prion epitopes and fusions thereof, that display enhanced immunogenicity are described. Also described are methods of treating and diagnosing prion disease.
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公开(公告)号：US09376476B2
公开(公告)日：2016-06-28
申请号：US14709877
申请日：2015-05-12
Applicant: University of Saskatchewan
Inventor： Scott Napper , Peter Hedlin , Philip Griebel , Lorne Babiuk , Neil Cashman , Avijit Chakrabartty , Andrew Potter
CPC classification number: C07K14/47 , A61K39/0007 , A61K2039/6037 , C07K7/06 , C07K7/08 , C07K16/2872 , C07K2317/34 , G01N33/6893 , G01N33/6896 , G01N2333/705 , G01N2800/2828
Abstract: Prion peptides comprising prion epitopes and fusions thereof, that display enhanced immunogenicity are described. Also described are methods of treating and diagnosing prion disease.
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5.发明申请Methods and Compositions for Species-Specific Kinome Microarrays 审中-公开物种特异性Kinome Microarrays的方法和组合公开(公告)号：US20140303010A1
公开(公告)日：2014-10-09
申请号：US14346490
申请日：2012-09-21
Applicant: University of Saskatchewan
Inventor： Brett Trost , Anthony Kusalik , Scott Napper , Ryan Arsenault , Philip Griebel
CPC classification number: G01N33/6845 , C07K14/43572 , C12Q1/485 , G01N33/6818 , G01N33/6842 , G01N2333/43565 , G01N2333/91205 , G01N2440/14 , G16B30/00
Abstract: A method of preparing a species-specific phosphorylation site peptide array for a target organism comprising: a) selecting a plurality of known non-target organism (NTO) phosphorylation site sequences and cognate known NTO phosphorylation polypeptide sequences from one or more NTO, each of the known NTO phosphorylation site sequences comprising at least 5 residues and less than 30 residues; b) identifying a matching target organism (TO) phosphorylation site sequence and cognate TO phosphorylation polypeptide sequence for one or more of the known NTO phosphorylation site sequences; c) determining the matching TO phosphorylation site sequences that correspond to orthologue polypeptides of the cognate known NTO phosphorylation polypeptide sequences; d) selecting the matching TO phosphorylation site sequences determined to correspond to orthologue polypeptides for inclusion on the array; wherein the matching TO phosphorylation site sequences that correspond to orthologue polypeptides are determined by calculating, for each matching phosphorylation site sequence identified in b), a similarity value between the TO phosphorylation polypeptide sequence corresponding to the TO phosphorylation site sequence and a TO polypeptide sequence matching the cognate known NTO polypeptide sequence.
Abstract translation: 制备靶生物的物种特异性磷酸化位点肽阵列的方法，包括：a）从一个或多个NTO中选择多个已知的非靶生物（NTO）磷酸化位点序列和同源的已知NTO磷酸化多肽序列，每个 已知的NTO磷酸化位点序列包含至少5个残基和少于30个残基; b）鉴定一种或多种已知NTO磷酸化位点序列的匹配靶生物（TO）磷酸化位点序列和同源TO磷酸化多肽序列; c）确定与同源已知的NTO磷酸化多肽序列的直向同源多肽相对应的匹配的TO磷酸化位点序列; d）选择确定为对应于直向同源多肽的匹配的TO磷酸化位点序列以包含在阵列上; 其中对应于直向同源多肽的匹配的TO磷酸化位点序列通过对于b）中鉴定的每个匹配的磷酸化位点序列计算，对应于TO磷酸化位点序列的TO磷酸化多肽序列与匹配的TO多肽序列之间的相似性值 同源已知的NTO多肽序列。
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