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    SUBSTITUTED CYCLOALKANECARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE AS ENDOTHELIN ANTAGONISTS
    23.
    发明申请
    SUBSTITUTED CYCLOALKANECARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE AS ENDOTHELIN ANTAGONISTS 审中-公开
    取代环烷酸衍生物，生产与应用，内皮素拮抗剂

    公开(公告)号：WO1995015944A1

    公开(公告)日：1995-06-15

    申请号：PCT/EP1994003914

    申请日：1994-11-26

    Applicant: BASF AKTIENGESELLSCHAFT ,  ALBRECHT, Hans-Peter ,  BÖHM, Hans-Joachim ,  RASCHACK, Manfred ,  UNGER, Liliane ,  WERNET, Wolfgang

    Inventor： BASF AKTIENGESELLSCHAFT

    IPC: C07D209/18

    CPC classification number: C07C205/56 ,  C07C62/06 ,  C07C62/18 ,  C07C62/38 ,  C07C69/757 ,  C07C229/46 ,  C07C229/50 ,  C07C235/34 ,  C07C2602/28 ,  C07D209/18

    Abstract: The invention describes compounds of formula (I), where A is an oxygen atom or a NH group; B is the radical -Zm-(CHQ)p-(CH=CH)q-(CH2)r-P, where Z is a -CO- group or -SO2-group, m is 0 or 1, p is 0, 1 or 2, q is 0, 1 or 2, r is 0, 1 or 2, Q is a hydrogen atom, a C1-4 alkyl radical, a carboxyl-, carboxamido- or carboxy-C1-4 alkyl group, and P is a hydrogen atom, an indolyl radical, or a phenyl radical possibly substituted by 1-3-C1-4 alkyl radicals, halogen atoms, trifluoromethyl-, hydroxy-, C1-4 alkoxy-, C1-4 acyloxy-, amino-, C1-5 acylamino-, sulfonamido-, nitro-, C1-5 acyl-, carboxyl- or thio-C1-4 alkyl groups, and/or a C1-2 alkylenedioxy group; D is an amino-, hydroxy-, C1-4 alkoxy, C1-4 alkylamino-, aryl-C1-4 alkylenoxy- or aryl-C1-4 alkyleneamino, where the aryl radicals represent a phenyl radical possibly substituted by 1-3-C1-4 alkyl radicals, halogen atoms, trifluoromethyl-, hydroxy-, C1-4 alkoxy-, C1-4 acyloxy-, amino-, C1-5 acylamino-, sulfonamido-, nitro-, C1-5 acyl-, carboxyl- or thio-C1-4 alkylene groups and/or a C1-2 alkylenedioxy group; X is a C1-4 alkyl radical or a phenyl radical possibly substituted by 1-3-C1-4 alkyl radicals, halogen atoms, trifluoromethyl-, hydroxy-, C1-4 alkoxy-, C1-4 acyloxy-, amino-, C1-5 acylamino-, sulfonamido-, nitro-, C1-5 acyl-, carboxyl- or thio-C1-4 alkylene groups and/or a C1-2 alkylenedioxy group; Y is a hydrogen atom, a C1-4 alkyl radical or a phenyl radical possibly substituted by 1-3-C1-4 alkyl radicals, halogen atoms, trifluoromethyl-, hydroxy-, C1-4 alkoxy-, C1-4 acyloxy-, amino-, C1-5 acylamino-, sulfonamido-, nitro-, C1-5 acyl-, carboxyl- or thio-C1-4 alkylene groups and/or a C1-2 alkylenedioxy group, or X and Y together represent a -(CH2)s group, where s is 3, 4 or 5, and 1 or 2 hydrogen atoms can be replaced by methyl groups, and n is 0 or 1, and possibly their salts with physiologically tolerable acids and bases. The compounds can be used to combat diseases.

    Abstract translation: 有式（I），其中A是氧原子或NH基团的发明中，B是基团-Zm-（CHQ）对 - （CH = CH）Q（CH 2）RP，其中Z是-CO - 或-SO 2基团，m是0或1，p是阿尔0，1或2，q为0，1或2，r是0，1或2，Q是氢原子，C 1-4 烷基，羧基，甲酰氨基，或羧基-C 1-4 - 烷基且P为氢原子或任选地被1-3个C 1-4烷基，卤素原子，三氟甲基，羟基，C 1-4烷氧基，C 1 -C 4-酰氧基，氨基，C 1-5酰氨基，磺酰氨基，硝基，C 1-5酰基，羧基或硫代C 1-4 - 烷基基团和/或C1-2亚烷基二氧基取代的苯基或 代表吲哚基团，D是氨基，羟基，C 1-4 - 烷氧基，C 1-4 - 烷基氨基，芳基-C 1-4 - 亚烷基或芳基-C 1-4亚烷基氨基，其中所述芳基任选被取代的1- 3个C 1-4烷基，卤素原子，三氟甲基，羟基，C 1-4 - 烷氧基，C 1-4 - 酰氧基，氨基，C 1-5酰氨基，磺 namido-，硝基，C 1-5酰基，羧基或硫代C1-4亚烷基基团和/或C 1-2 - 亚烷基二氧基取代的苯基，X表示C 1-4 - 烷基或任选被1个 -3 C 1-4烷基，卤素，三氟甲基，羟基，C 1-4烷氧基，C 1-4酰氧基，氨基，C 1-5酰氨基，磺酰氨基，硝基，C1-5- 亚烷基硫基-C 1-4 - 酰基，羧基或和/或亚烷基二C1-2取代的苯基基团，Y表示氢原子，C 1-4烷基或任选地被1-3 C 1-4烷基的基团，卤原子 甲基，三氟甲基，羟基，C 1-4 - 烷氧基，C 1-4 - 酰氧基，氨基，C 1-5酰氨基，磺酰氨基，硝基，C 1-5酰基，羧基或硫代C1 -4 - 亚烷基和/或C 1-2 - 亚烷基二氧基取代的苯基基团，或X和Y一起形成 - （CH 2）平均的小组，其中s是在其通过甲基基团1个或2个氢原子的数目3，4或5个 可以被替换，并且n为数字0或1， 和任选其盐与生理上可接受的酸或碱。 所述化合物适于防治疾病。

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