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公开(公告)号：KR1020130056957A
公开(公告)日：2013-05-31
申请号：KR1020110122624
申请日：2011-11-23
Applicant: (주)아모레퍼시픽
CPC classification number: A61L27/24 , A61F2/105 , A61L27/3804 , A61L27/60
Abstract: PURPOSE: A measuring method of a skin regeneration effect using a skin equivalent is provided to directly evaluate a skin regeneration effect of a material by performing a wound treatment analysis using a punch biopsy. CONSTITUTION: A dermis layer of a skin regeneration comprises an inside dermis layer and an outside dermis layer. The inside dermis layer comprises a collagen and a fibroblast. The outside dermis layer comprises a collagen. The skin equivalent suppresses a contraction of the dermis. A measuring method of a skin regeneration effect comprises the following steps: a step of making a wound in a epidermis layer of a skin equivalent; a step in which a testing material is processed in a generated wound for 5-10 days; and a step of observing an epimorphic regeneration state of the skin equivalent with time with performing H&E stain(Hematoxylin and Eosin stain) at 2-3 days intervals after processing the testing material. [Reference numerals] (AA) Epidermis layer; (BB) Damaged portion of epidermis; (CC) Dermis layer
Abstract translation: 目的：提供使用皮肤当量的皮肤再生效果的测定方法，通过使用穿孔活检进行伤口处理分析，直接评价材料的皮肤再生效果。 构成：皮肤再生的真皮层包括真皮内层和外层真皮层。 内层真皮层包含胶原和成纤维细胞。 外部真皮层包含胶原蛋白。 皮肤等效抑制真皮的收缩。 皮肤再生效果的测定方法包括以下步骤：在皮肤表皮等级制作伤口的步骤; 将测试材料在产生的伤口中加工5-10天的步骤; 以及在处理测试材料之后以2-3天间隔观察皮肤相当于皮肤异化再生状态的步骤，每隔2-3天进行H＆E染色（苏木精和伊红染色）。 （AA）表皮层; （BB）表皮损伤部位; （CC）真皮层
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22.发明公开
公开(公告)号：KR1020130039026A
公开(公告)日：2013-04-19
申请号：KR1020110103448
申请日：2011-10-11
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/97 , A61K2800/5922 , A61K2800/78 , A61Q19/08
Abstract: PURPOSE: A composition containing a mixture extract of Lycium chinense Miller and Pinus densiflora Siebold et Zuccarini for antiaging through activation of a retinoic acid receptor is provided to ensure excellent skin antiaging or anti-wrinkling. CONSTITUTION: A cosmetic composition for antiaging contains a mixture extract of Lycium chinense Miller and Pinus densiflora Siebold et Zuccarini as an active ingredient. The mixture extract contains 40-60 wt% of the Lycium chinense Miller extract and 40-60 wt% of the Pinus densiflora Siebold et Zuccarini extract. The composition activates a retinoic acid receptor. The composition also prevents wrinkles by suppressing collagenase expression.
Abstract translation: 目的：提供含有枸杞子和松果松混合提取物的组合物，用于通过活化视黄酸受体进行抗衰老以确保优异的皮肤抗衰老或抗皱纹。 构成：用于抗衰老的化妆品组合物含有枸杞的混合物提取物和松果松（Siebold et Zuccarini）作为活性成分。 混合物提取物含有40-60重量％的枸杞提取物和40-60重量％的松属松属Siebold和Zuccarini提取物。 该组合物激活视黄酸受体。 该组合物还通过抑制胶原酶表达来防止皱纹。
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公开(公告)号：KR101231993B1
公开(公告)日：2013-02-08
申请号：KR1020120131643
申请日：2012-11-20
Applicant: (주)아모레퍼시픽
Inventor： 나용주
CPC classification number: C12Q1/6834 , C12Q1/6876 , C12Q2525/205 , G01N33/5308 , G01N33/577
Abstract: PURPOSE: A kit and a method for diagnosing seborrheic keratosis are provided to quickly diagnose seborrheic keratosis occurrence using a marker gene. CONSTITUTION: A kit for diagnosing seborrheic keratosis contains polynucleotide containing 10 or more continuous nucleotides or a complementary polynucleotide thereof; and a solid phase support on which a polynucleotide is conjugated on the surface. A kit for diagnosing seborrheic keratosis contains: a polynucleotide containing 18-22 continuous nucleotides as a polynucleotide fragment of WISP2(AK074695); and one or more polynucleotides containing the 18-22 continuous nucleotides, which are a complementary polynucleotide. The kit is used for diagnosing seborrheic keratosis. A method for providing necessary information for diagnosing seborrheic keratosis comprises a step of determining seborrheic keratosis when the expression level of WISP2(AK07495) gene on a subject epidermis is lower than the level on a control group.
Abstract translation: 目的：提供一种用于诊断脂溢性角化病的试剂盒和方法，以使用标记基因快速诊断脂溢性角化病发生。 构成：用于诊断脂溢性角化病的试剂盒含有含有10个以上连续核苷酸的多核苷酸或其互补多核苷酸; 和表面上共轭多核苷酸的固相载体。 用于诊断脂溢性角化病的试剂盒包含：含有18-22个连续核苷酸作为WISP2（AK074695）多核苷酸片段的多核苷酸; 和一个或多个含有18-22个连续核苷酸的多核苷酸，其是互补多核苷酸。 该套件用于诊断脂溢性角化病。 提供用于诊断脂溢性角化病的必要信息的方法包括当对象表皮上的WISP2（AK07495）基因的表达水平低于对照组的水平时，确定脂溢性角化病的步骤。
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公开(公告)号：KR1020110007540A
公开(公告)日：2011-01-24
申请号：KR1020090065107
申请日：2009-07-16
Applicant: (주)아모레퍼시픽
IPC: A61K8/49 , A61Q19/08 , A61K31/352 , A61P17/18
CPC classification number: A61K8/498 , A61K8/418 , A61K8/466 , A61K2800/522 , A61Q19/08
Abstract: PURPOSE: A composition for skin anti-aging is provided to suppress matrix metalloprotease activation without skin irritation. CONSTITUTION: A composition for skin anti-aging contains 0.01-20 weight% of compound of chemical formula 1, isomer or pharmaceutically acceptable salt thereof as an active ingredient. The composition is used for preventing or treating wrinkling and skin aging. The composition is a pharmaceutical composition or cosmetic composition. The pharmaceutical composition is manufactured in the form of lotion, ointment, gel, cream, patch or spray. The cosmetic composition is used in the form of essence, nutrition cream, massage cream, pack, gel, essence, eye cream, cleansing cream, cleansing foam, pack, and powder.
Abstract translation: 目的：提供皮肤抗衰老的组合物，以抑制基质金属蛋白酶活化而无皮肤刺激。 构成：用于皮肤抗衰老的组合物含有0.01-20重量％的化学式1的化合物，其异构体或其药学上可接受的盐作为活性成分。 该组合物用于预防或治疗皱纹和皮肤老化。 该组合物是药物组合物或化妆品组合物。 药物组合物以洗剂，软膏，凝胶，霜剂，贴剂或喷雾剂的形式制备。 化妆品组合物以精华，营养霜，按摩霜，包装，凝胶，精华，眼霜，清洁霜，清洁泡沫，包装和粉末的形式使用。
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公开(公告)号：KR1020080044612A
公开(公告)日：2008-05-21
申请号：KR1020060113663
申请日：2006-11-17
Applicant: (주)아모레퍼시픽
IPC: A61K36/575 , A61P17/00
CPC classification number: A61K8/97 , A61Q19/02 , Y10S514/846 , Y10S514/847
Abstract: A composition comprising an extract of Magnolia Obovata bark is provided to inhibit melanogenesis by inhibiting the activity of c-kit protein expressed in melanocyte effectively, thereby showing excellent whitening effect. A composition for inhibiting c-kit protein activity comprises 0.0001-10 wt.% of an extract of Magnolia Obovata bark as an effective ingredient, wherein the extract controls function of melanocyte by inhibiting signalling of cells in a melanocyte participated by a C-kit protein.
Abstract translation: 通过抑制黑素细胞表达的c-kit蛋白的活性，提供含有木兰提取物的组合物，以抑制黑素生成，从而显示优异的美白效果。 用于抑制c-kit蛋白活性的组合物包含0.0001-10重量％的木兰木皮提取物作为有效成分，其中所述提取物通过抑制C-kit蛋白质参与的黑素细胞中细胞的信号传导来控制黑素细胞的功能 。
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Patent Agency Ranking
公开(公告)号：KR100716891B1
公开(公告)日：2007-05-09
申请号：KR1020050103808
申请日：2005-11-01
Applicant: (주)아모레퍼시픽
IPC: C07D417/04
Abstract: 본 발명은 하기 화학식 1로 표시되는 피리딘 티아졸 카복사마이드 유도체 또는 그의 약제학적으로 허용되는 염, 이의 제조방법 및 이를 함유하는 씨-킷트 활성 억제용 조성물 또는 피부 미백용 조성물에 관한 것으로, 하기 화학식 1의 화합물은 씨-킷트(c-Kit) 활성 억제작용에 의해 멜라닌 생성을 억제함으로써 피부의 색소침착을 개선시켜 미백 효과를 나타내는 효능이 있으므로, 이를 함유하는 씨-킷트 활성 억제용 조성물 및 피부 미백용 조성물은 화장료 조성물 또는 약학 조성물로써 유용하게 이용될 수 있다.
[화학식 1]
(상기 식에서,
R
1 은 페닐이고, n 은 1, 2 또는 3이다.)
피리딘 티아졸 카복사마이드, 씨 킷트, 멜라닌, 미백, 화장료.Abstract translation: 本发明涉及式（I）吡啶噻唑甲酰衍生物或其盐药学上可接受的由下式表示，其制备方法和含有它的种子 - 涉及一种组合物用于试剂盒的抑制组合物或皮肤美白，式 化合物1是的c-kit（的c-kit）由活化抑制作用抑制黑色素产生和改善皮肤色素沉着，因此效力表示美白效果，含有相同的试剂盒的抑制组合物和皮肤美白的种子 可以有利地用作化妆品组合物或药物组合物。
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公开(公告)号：KR1020070046329A
公开(公告)日：2007-05-03
申请号：KR1020050102894
申请日：2005-10-31
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 유효성분으로서 식물 추출물을 함유하는 c-kit 단백질 억제용 조성물에 관한 것이다. 보다 구체적으로, 본 발명은 식물추출물로서 풍년화(
Hamamelis japonica ), 적작약(
Paeonia lactiflora ), 복사나무(
Prunus persica ) 및 해당화(
Rosa rugosa ) 추출물로 이루어진 군으로부터 선택된 1종 이상을 함유하는 c-kit 단백질 억제용 조성물에 관한 것이다. 본 발명에 따른 조성물은 유효성분으로서 함유된 식물추출물이 멜라노사이트(melanocyte)의 세포 표면 단백질인 c-kit 단백질의 활성을 억제하여 멜라닌(Melanin)의 생성을 저해할 수 있으므로 우수한 미백효과를 나타낸다.
c-kit, 풍년화, 적작약, 복사나무, 해당화, 멜라노사이트, 멜라닌, 미백-
公开(公告)号：KR101972071B1
公开(公告)日：2019-04-24
申请号：KR1020120009404
申请日：2012-01-31
Applicant: (주)아모레퍼시픽
IPC: A61K8/9706 , A61K8/9711 , A61K8/9722 , A61K8/9789 , A61K8/22 , A61K8/96 , A61Q19/02 , A61Q19/08
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公开(公告)号：KR101869714B1
公开(公告)日：2018-06-21
申请号：KR1020110103448
申请日：2011-10-11
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/97 , A61K2800/5922 , A61K2800/78 , A61Q19/08
Abstract: 본발명은구기자및 솔잎의혼합추출물을유효성분으로함유하는항노화용조성물에관한것이다. 보다상세하게는천연원료인구기자및 솔잎의혼합추출물을함유하여레티노익산유용체의활성화를통한피부항노화또는주름개선효과가탁월한피부외용제조성물에관한것이다.
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30.发明授权
公开(公告)号：KR101781466B1
公开(公告)日：2017-09-26
申请号：KR1020110037904
申请日：2011-04-22
Applicant: (주)아모레퍼시픽
Abstract: 본발명은연꽃추출물및 오매추출물중에서하나이상을유효성분으로함유하는항산화활성을가지는피부외용제조성물을제공한다. 본발명의조성물은항산화효과가우수하여화장료조성물또는약학조성물로응용가능하다. 또한, 본발명의조성물은피부홍반방지, 피부톤개선, 피부노화방지효과도우수하다.
Abstract translation: 本发明提供含有莲子提取物和燕麦提取物中的至少一种作为有效成分的具有抗氧化活性的皮肤外用组合物。 本发明的组合物具有优异的抗氧化效果，可以作为化妆品组合物或药物组合物使用。 本发明的组合物在防止皮肤红斑，改善皮肤色调和防止皮肤老化方面也是优异的。
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