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公开(公告)号：KR1020090132173A
公开(公告)日：2009-12-30
申请号：KR1020080058303
申请日：2008-06-20
IPC: A61K9/70 , A61K31/122
Abstract: PURPOSE: A transdermal absorption composition containing loxoprofen or its salt is provided to suppress generation of crystallization and ensure adhesion which is applicable to joint of human body. CONSTITUTION: A transdermal absorption composition contains 0.5-50 weight% of loxoprofen or its salt, 7-15 weight% of glycerol monolaurate as absorber, 20-92 weight% of adhesion polymer and 0.1-20 weight% of sorbitan ester as a stabilizing agent. The sorbitan ester is sorbitan sesquioleate or sorbitan sesquistearate. The composition further contains acetic acid, lactic acid or myristic acid. The salt of loxoprofen is loxoprofen sodium.
Abstract translation: 目的：提供含有洛索洛芬或其盐的透皮吸收组合物，以抑制结晶的产生并确保适用于人体关节的粘合。 构成：透皮吸收组合物含有0.5-50重量％的洛索洛芬或其盐，7-15重量％的甘油单月桂酸酯作为吸收剂，20-92重量％的粘合聚合物和0.1-20重量％的脱水山梨醇酯作为稳定剂 。 脱水山梨糖醇酯是脱水山梨糖醇倍半油酸酯或脱水山梨糖醇倍半硬脂酸酯。 组合物还含有乙酸，乳酸或肉豆蔻酸。 洛索洛芬的盐是洛索洛芬钠。
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公开(公告)号：KR1020080006961A
公开(公告)日：2008-01-17
申请号：KR1020060066357
申请日：2006-07-14
IPC: A61K9/70
CPC classification number: A61K9/7038 , A61K31/192 , A61K31/196
Abstract: A transdermal preparation is provided to promote the drug absorption by the skin hydration through a hydrophobic adhesive layer, show continuous and high effect of a drug by maintaining the thermodynamic activity of the hydrophobic drug in an adhesive caused by moisture discharged from skin and be able to reduce the cost and the time due to a very simple preparing process. A transdermal preparation for a hydrophobic drug comprises a supportive layer(1) which is the uppermost portion of a layered structure and has the elasticity; a hydrophobic adhesive layer(2) which is layered under the supportive layer and prevents the loss of moisture absorbed from skin and the reverse conversion of the drug; and a drug containing adhesive layer(3) which is layered under the hydrophobic adhesive layer, includes a drug and attaches the transdermal preparation to the skin and is characterized in that the drug adhesive layer includes a hydrophobic drug such as a non-steroidal antiphlogistics and an absorption promoting agent, where a hydrophobic adhesive of the hydrophobic adhesive layer is selected from the group consisting of polyisobutylene adhesive, styrene-isoprene-styrene adhesive, and styrene-butadiene-styrene adhesive, the drug containing adhesive layer is an acrylate polymer made from acrylate, hydroxypropyl acrylate, acrylamide, acrylamide vinyl acetate, vinyl derivative, methacrylate, hydroxypropyl methacrylate and methacrylamide. The preparation further comprises a release layer(4) which is layered under the drug adhesive layer and protects the drug adhesive layer before use.
Abstract translation: 提供透皮制剂以通过疏水粘合剂层通过皮肤水合促进药物吸收，通过将疏水药物的热力学活性保持在由皮肤排出的水分引起的粘合剂中，显示出药物的连续和高效果，并且能够 由于非常简单的准备过程，降低了成本和时间。 用于疏水性药物的透皮制剂包括支撑层（1），其是层状结构的最上部并具有弹性; 疏水性粘合剂层（2），其被层叠在支撑层下方并防止皮肤吸收的水分的损失和药物的逆转换; 和层叠在疏水性粘合剂层下面的药物含有粘合剂层（3）的药物包含药物，并将透皮制剂附着于皮肤，其特征在于，所述药物粘合剂层包括疏水性药物，例如非甾体消炎药， 吸水促进剂，其中疏水性粘合剂层的疏水性粘合剂选自聚异丁烯粘合剂，苯乙烯 - 异戊二烯 - 苯乙烯粘合剂和苯乙烯 - 丁二烯 - 苯乙烯粘合剂，所述药物粘合剂层是由 丙烯酸酯，丙烯酸羟丙酯，丙烯酰胺，丙烯酰胺乙酸乙烯酯，乙烯基衍生物，甲基丙烯酸酯，甲基丙烯酸羟丙酯和甲基丙烯酰胺。 该制剂还包括层叠在药物粘合剂层下面的释放层（4），并在使用前保护药物粘合剂层。
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公开(公告)号：KR1020080006960A
公开(公告)日：2008-01-17
申请号：KR1020060066353
申请日：2006-07-14
IPC: A61K9/70
CPC classification number: A61K9/7061 , A61K47/32
Abstract: A transdermal preparation is provided to continuously allow a highly concentrated hydrophobic drug to be absorbed into skin until a patch is detached from the skin with minimized skin side effects and provide the enough adhesive capability during the time of exhibiting the medical efficacy by being attached to the skin. A transdermal preparation for a hydrophobic drug comprises a supportive layer(1) which is the uppermost portion of a layered structure and has the elasticity; a hydrophobic adhesive layer(2) which is layered under the supportive layer and prevents the loss of moisture absorbed from skin and the reverse conversion of the drug; and a drug adhesive layer(3) which is layered under the hydrophobic adhesive layer, includes a drug and attaches the transdermal preparation to the skin and is characterized in that the drug adhesive layer includes a hydrophobic drug such as a non-steroidal antiphlogistics and an acryl adhesive agent and the acryl adhesive agent includes a hydrophilic monomer promoting the skin absorption from the skin and is selected from the group consisting of acrylic acid, methyl methacrylate, ethyl acrylate, hydroxyethyl acrylate, butyl acrylate, octyl acrylate, 2-ethylhexyl acrylate, and hexyl acrylate. The preparation further comprises a release layer(4) which is layered under the drug adhesive layer and protects the drug adhesive layer before use.
Abstract translation: 提供透皮制剂以连续地允许高度浓缩的疏水性药物被吸收到皮肤中，直到贴片从皮肤上分离出来，使皮肤的副作用最小化，并且在展示医疗功效的时间期间提供足够的粘合能力， 皮肤。 用于疏水性药物的透皮制剂包括支撑层（1），其是层状结构的最上部并具有弹性; 疏水性粘合剂层（2），其被层叠在支撑层下方并防止皮肤吸收的水分的损失和药物的逆转换; 以及层叠在疏水性粘合剂层下方的药物粘合剂层（3），包括药物，并且将透皮制剂附着于皮肤，其特征在于，所述药物粘合剂层包括疏水性药物，例如非甾体消炎药和 丙烯酸粘合剂和丙烯酸粘合剂包括促进皮肤吸收皮肤的亲水单体，并且选自丙烯酸，甲基丙烯酸甲酯，丙烯酸乙酯，丙烯酸羟乙酯，丙烯酸丁酯，丙烯酸辛酯，丙烯酸2-乙基己酯， 和丙烯酸己酯。 该制剂还包括层叠在药物粘合剂层下面的释放层（4），并在使用前保护药物粘合剂层。
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公开(公告)号：KR1020070108688A
公开(公告)日：2007-11-13
申请号：KR1020060041041
申请日：2006-05-08
Applicant: (주)아모레퍼시픽
CPC classification number: A61K9/7053 , A61K9/7061 , A61K9/7084
Abstract: A composition for transdermal absorption is provided to increase solubility of non-steroidal anti-inflammatory drug as an effective ingredient by using a small amount of solubilizer, thereby containing high concentration of effective ingredient without skin irritation. A formulation comprising a polymeric matrix is also provided to maximize skin absorption of the effective ingredient. A composition for transdermal absorption comprises 0.1-50 wt.% of a non-steroidal anti-inflammatory drug, 0.01-10 wt.% of alkali metal-containing alcohol derivatives represented by the formula(1): M-O-R in which M is a Group I metal, O is oxygen and R is C1-5 alkyl as a solubilizer, 40-98 wt.% of a polymer adhesive and a volatile solvent. A formulation for transdermal absorption comprises a release paper, a polymeric matrix(2) prepared by coating the release paper(3) with the composition for transdermal absorption, and a support(1), sequentially, and has the thickness of 10-120 mum.
Abstract translation: 提供透皮吸收用组合物以通过使用少量增溶剂来增加非甾体抗炎药物作为有效成分的溶解度，由此含有高浓度的有效成分而不引起皮肤刺激。 还提供了包含聚合物基质的制剂以使有效成分的皮肤吸收最大化。 用于经皮吸收的组合物包含0.1-50重量％的非甾体抗炎药，0.01-10重量％的由式（1）表示的含碱金属的醇衍生物：MOR，其中M是一个 I金属，O是氧，R是作为增溶剂的C 1-5烷基，40-98重量％的聚合物粘合剂和挥发性溶剂。 用于透皮吸收的制剂包括脱模纸，通过用离子纸（3）涂覆用于经皮吸收的组合物和支撑体（1）制备的聚合物基质（2），并且具有10-120μm的厚度 。
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公开(公告)号：KR1020170042905A
公开(公告)日：2017-04-20
申请号：KR1020150142099
申请日：2015-10-12
Applicant: (주)아모레퍼시픽
IPC: A61L27/14 , C08L101/16
CPC classification number: A61L27/14 , C08L101/16
Abstract: 본발명은기공형성유도물질과소수성생분해성고분자를휘발성용매에용해시키는것을포함하는고분자용액의제조단계; 상기고분자용액을물 또는상안정화제를포함하는수용액에분산시켜 O/W(Oil in Water) 형태의에멀젼(emulsion)을형성하는단계; 상기고분자용액이분산된수용액상에서휘발성용매를휘발시켜상기소수성생분해성고분자를고형화하여, 소수성생분해성고분자와상기기공형성유도물질간의자발적상분리를발생시켜 O/W(Oil in Water) 형태의에멀젼(emulsion)에포함된오일상고분자용액을 O/S(Oil in Solid) 미립구로변환시키는것을포함하는중공형다공성미립구의제조단계; 및상기중공형다공성미립구에포함된기공형성유도물질을제거하는단계를포함하는중공형다공성미립구의제조방법을제공한다.
Abstract translation: 本发明是一种用于制备聚合物溶液，其包含溶解步骤中的孔隙形成物质和诱导在挥发性溶剂中的疏水性可生物降解的聚合物; 形成聚合物溶液的乳液（乳液）分散在包含水或清洗剂sangan O / W（水油）形式的水溶液; 和由挥发性溶剂以固化在水溶液中，其中所述聚合物溶液分散在疏水性生物可降解聚合物的蒸发，疏水性可生物降解的生成乳液形式的聚合物和成孔诱导剂的O / W（水油）之间的自发相分离（ 乳液）制造其中包括将每天聚合物溶液共形多孔微球的O-阶段到O / S（包含在固体）微球体油; 它提供了一种生产去除包含在该共形多孔微球的诱导成孔材料的步骤的多孔微球的共形方法。
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Patent Agency Ranking
公开(公告)号：KR101490708B1
公开(公告)日：2015-02-09
申请号：KR1020080058303
申请日：2008-06-20
IPC: A61K9/70 , A61K31/122
Abstract: 본 발명은 록소프로펜 또는 그의 염을 포함하는 경피 흡수용 조성물 및 이를 포함하는 경피 투여 첩부제에 관한 것이다. 본 발명에 따른 경피 흡수용 조성물 및 경피 투여 첩부제는 높은 경피 흡수도를 나타내면서 록소프로펜 또는 그의 염 등의 결정 생성을 효과적으로 억제하며, 움직임이 많은 관절 부위에 적용가능한 적절한 점착력도 갖추고 있으므로, 다양한 질환에 대한 소염진통용 외용 제제로서 유용하게 사용될 수 있다.
록소프로펜, 경피 흡수, 첩부제-
公开(公告)号：KR1020150001070A
公开(公告)日：2015-01-06
申请号：KR1020130073708
申请日：2013-06-26
Applicant: (주)아모레퍼시픽
IPC: A61K31/715 , A61K31/70 , A61K8/73 , A61P17/00
CPC classification number: A61K31/737 , A23L29/30 , A23V2200/318 , A61K8/73 , A61K9/0019 , A61K31/728
Abstract: 본 명세서는 글루코스아미노글라이칸의 하나인 콘드로이친설페이트와 히알루론산을 함유하는 콜라겐의 생성을 촉진하는 조성물에 관한 것으로서, 피부 조직에 처리하였을 때 뛰어난 콜라겐 생성 효과를 나타내고, 피부 조직을 수복시키는 것을 촉진 하는 조성물에 관한 것이다.
Abstract translation: 本说明书涉及促进产生胶原蛋白的组合物，包括作为一种糖胺聚糖的硫酸软骨素和透明质酸，并且涉及当组合物处理皮肤组织时对胶原产生具有优异效果的组合物 并促进皮肤组织的恢复。
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公开(公告)号：KR101327083B1
公开(公告)日：2013-11-07
申请号：KR1020100043161
申请日：2010-05-07
Applicant: (주)아모레퍼시픽
CPC classification number: A61K9/06 , A61K8/042 , A61K2800/412 , A61L27/52 , A61L27/54 , A61L2430/24 , A61L2430/34 , A61Q19/00
Abstract: 본 발명은 물, 분산 보조제, 수용성 고분자, pH 조절제 및 가교제를 투입하여 조성물을 제조하는 단계; 및 상기 단계에서 제조한 조성물에서 분산 보조제를 제거하는 단계를 포함하는 수불용성 겔 조성물 제조 방법을 개시한다. 상기 방법을 통해 우수한 품질의 수불용성 겔 조성물을 효율적으로 제조할 수 있다. 또한 본 발명은 상기 수불용성 겔 조성물 제조 방법에 의해 제조된 수불용성 겔 조성물을 개시한다.
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公开(公告)号：KR1020130057640A
公开(公告)日：2013-06-03
申请号：KR1020110123485
申请日：2011-11-24
Applicant: (주)아모레퍼시픽
CPC classification number: C08L5/08 , A61K9/06 , A61K47/36 , A61L15/28 , A61L27/20 , A61L2400/06 , C08B37/0072 , A61K9/10 , A61K47/50
Abstract: PURPOSE: A method for preparing a water-insoluble gel composition is provided to minimize molecular weight reduction of polysaccharides using a small amount of a crosslinking agent and to ensure excellent strength and stability. CONSTITUTION: A method for preparing a water-insoluble gel composition comprises: a step of mixing water-soluble polysaccharides, an epoxy crosslinking agent, a basic compound, and a solvent; and a step of drying the mixture under vacuum at 1-30 deg. C to remove the solvent. The vacuum pressure is 1-30 mmHg. The solvent is removed by concentrating the water soluble polysaccharides in a concentration of 50-99 wt%. The molecular weight of the water soluble polysaccharides is 500-5,000 kDa. [Reference numerals] (AA) Volume of gel(%); (BB) Example 11
Abstract translation: 目的：提供一种制备水不溶性凝胶组合物的方法，以尽量减少使用少量交联剂的多糖的分子量降低并确保优异的强度和稳定性。 构成：制备水不溶性凝胶组合物的方法包括：将水溶性多糖，环氧交联剂，碱性化合物和溶剂混合的步骤; 以及在1-30度的真空下干燥混合物的步骤。 C去除溶剂。 真空压力为1-30mmHg。 通过浓缩50-99重量％的水溶性多糖来除去溶剂。 水溶性多糖的分子量为500-5,000kDa。 （标号）（AA）凝胶体积（％）; （BB）实施例11
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