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    판두라틴 유도체를 함유하는 피부 미백용 화장료 조성물
    21.
    发明授权
    판두라틴 유도체를 함유하는 피부 미백용 화장료 조성물 有权
    白皮质组合物外用于含有潘多林衍生物的皮肤

    公开(公告)号：KR100829819B1

    公开(公告)日：2008-05-16

    申请号：KR1020070054863

    申请日：2007-06-05

    Applicant: (주)아모레퍼시픽 ,  황재관

    Inventor： 이찬우 ,  김한성 ,  김덕희 ,  장이섭 ,  윤지훈 ,  심재석 ,  황재관

    IPC: A61K8/35 ,  A61K8/34 ,  A61Q19/02

    Abstract: A skin whitening cosmetic composition comprising a panduratin derivative or an extract of Kaempferia Pandurata is provided to be safely used to skin without side effects and show excellent pigmentation inhibitory effect by inhibiting melanogenesis, thereby improving liver spots or freckles and showing excellent skin whitening effect. A skin whitening cosmetic composition comprises 0.001-10 wt.% of at least one panduratin derivative selected from the group consisting of compounds represented by formulae(1) to (3), wherein the panduratin derivative is extracted from Kaempferia Pandurata. Further, the skin whitening cosmetic composition is cosmetic water, cream, massage cream, essence, eye cream, eye essence, cleansing cream, cleansing form, cleansing water, pack, gel, powder, body lotion, body cream, body oil and body essence.

    Abstract translation: 提供一种皮肤美白化妆品组合物，其包含潘多汀衍生物或山茶皮提取物以安全地用于皮肤而没有副作用，并通过抑制黑素生成显示出优异的色素沉着抑制作用，从而改善肝斑或雀斑并显示出优异的皮肤美白效果。 皮肤美白化妆品组合物包含0.001-10重量％的至少一种选自由式（1）至（3）表示的化合物的潘多肽衍生物，其中所述潘多汀衍生物从山茶中提取。 此外，皮肤美白化妆品组合物是化妆水，奶油，按摩霜，精华，眼霜，眼睛精华，清洁霜，清洁剂，清洁水，包装，凝胶，粉末，身体乳液，身体霜，身体油和身体精华 。

    히드록시벤조산 아미드 화합물과 그 제조방법 및 이를함유하는 미백화장료 조성물
    22.
    发明授权
    히드록시벤조산 아미드 화합물과 그 제조방법 및 이를함유하는 미백화장료 조성물 有权
    히드록시벤조산아미드화합물과그제조방법및이를함유하는미백화장료조성물

    公开(公告)号：KR100643514B1

    公开(公告)日：2006-11-23

    申请号：KR1020050041060

    申请日：2005-05-17

    Applicant: (주)아모레퍼시픽

    Inventor： 백흥수 ,  이찬우 ,  노호식 ,  안수미 ,  김연준 ,  주희경 ,  이해광 ,  김덕희 ,  장이섭

    IPC: C07C233/64 ,  A61K8/368

    Abstract: Provided are a hydroxybenzoic acid amide compound which suppresses the generation of melanin, its preparation method, and a whitening cosmetic composition containing the compound. The hydroxybenzoic acid amide compound is represented by the formula 1, wherein R1 and R2 are H or OH. The method comprises the steps of dissolving hydroxybenzoic acid in a solvent, adding a catalyst and a base drop by drop, and reacting it with acetic anhydride to prepare an acetylated compound represented by the formula II; dissolving the acetylated compound of the formula II in a solvent and adding a base, ethyl chloroformate and adamantamine to prepare an amide compound represented by the formula III; and reacting the amine compound of the formula III with a base to hydrolyze it (See the reaction scheme 1), wherein R3 and R4 is H or an acetoxy group.

    Abstract translation: 本发明提供抑制黑色素生成的羟基苯甲酸酰胺化合物及其制备方法和含有该化合物的美白化妆品组合物。 羟基苯甲酸酰胺化合物由式1表示，其中R 1和R 2是H或OH。 该方法包括以下步骤：将羟基苯甲酸溶解在溶剂中，逐滴加入催化剂和碱，并使其与乙酸酐反应以制备式II表示的乙酰化化合物; 将式II的乙酰化的化合物溶解在溶剂中并加入碱，氯甲酸乙酯和金刚烷胺以制备式III表示的酰胺化合物; 和使式III的胺化合物与碱反应以水解（参见反应方案1），其中R 3和R 4是H或乙酰氧基。

    몰식자산 아미드 화합물과 그 제조방법 및 이를 함유하는화장료 조성물
    23.
    发明授权
    몰식자산 아미드 화합물과 그 제조방법 및 이를 함유하는화장료 조성물 有权
    몰식자산아미드화합물과그제조방법및이를함유하는화장료조성물

    公开(公告)号：KR100636737B1

    公开(公告)日：2006-10-20

    申请号：KR1020050032607

    申请日：2005-04-20

    Applicant: (주)아모레퍼시픽

    Inventor： 이찬우 ,  백흥수 ,  노호식 ,  최현정 ,  박창훈 ,  배지현 ,  김덕희 ,  장이섭

    IPC: C07C225/20

    Abstract: Provided are a gallic acid adamantamine amide compound which inhibits the generation of melanin, a method for preparing the compound, and a cosmetic composition containing the compound. The gallic acid adamantamine amide compound is represented by the formula 1. The method comprises the steps of dissolving gallic acid in a solvent, adding a catalyst and a base to the solution drop by drop, and reacting it with acetic anhydride to prepare the acetylated compound represented by the formula II (See the reaction scheme 1); dissolving the acetylated compound in a solvent and adding a base, ethyl chloroformate and adamantamine to prepare the amide compound represented by the formula III; and reacting the obtained amide compound with a base to hydrolyze it, thereby preparing the gallic acid adamantamine amide compound represented by the formula 1. Preferably the catalyst is dimethyl aminopyridine; and the base is triethylamine.

    Abstract translation: 本发明提供抑制黑色素生成的没食子酸金刚胺酰胺化合物，其制备方法以及含有该化合物的化妆品组合物。 没食子酸金刚烷胺酰胺化合物由式1表示。该方法包括以下步骤：将没食子酸溶解在溶剂中，逐滴向溶液中加入催化剂和碱，并使其与乙酸酐反应以制备乙酰化的化合物 由式II表示（参见反应方案1）; 将乙酰化的化合物溶解在溶剂中，加入碱，氯甲酸乙酯和金刚烷胺制备式III所示的酰胺化合物; 并使所得酰胺化合物与碱反应以将其水解，从而制备式1代表的没食子酸金刚烷胺酰胺化合物。优选该催化剂是二甲基氨基吡啶; 碱是三乙胺。

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