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公开(公告)号：KR100829819B1
公开(公告)日：2008-05-16
申请号：KR1020070054863
申请日：2007-06-05
Abstract: A skin whitening cosmetic composition comprising a panduratin derivative or an extract of Kaempferia Pandurata is provided to be safely used to skin without side effects and show excellent pigmentation inhibitory effect by inhibiting melanogenesis, thereby improving liver spots or freckles and showing excellent skin whitening effect. A skin whitening cosmetic composition comprises 0.001-10 wt.% of at least one panduratin derivative selected from the group consisting of compounds represented by formulae(1) to (3), wherein the panduratin derivative is extracted from Kaempferia Pandurata. Further, the skin whitening cosmetic composition is cosmetic water, cream, massage cream, essence, eye cream, eye essence, cleansing cream, cleansing form, cleansing water, pack, gel, powder, body lotion, body cream, body oil and body essence.
Abstract translation: 提供一种皮肤美白化妆品组合物，其包含潘多汀衍生物或山茶皮提取物以安全地用于皮肤而没有副作用，并通过抑制黑素生成显示出优异的色素沉着抑制作用，从而改善肝斑或雀斑并显示出优异的皮肤美白效果。 皮肤美白化妆品组合物包含0.001-10重量％的至少一种选自由式（1）至（3）表示的化合物的潘多肽衍生物，其中所述潘多汀衍生物从山茶中提取。 此外，皮肤美白化妆品组合物是化妆水，奶油，按摩霜，精华，眼霜，眼睛精华，清洁霜，清洁剂，清洁水，包装，凝胶，粉末，身体乳液，身体霜，身体油和身体精华 。
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公开(公告)号：KR1020090093477A
公开(公告)日：2009-09-02
申请号：KR1020080019016
申请日：2008-02-29
CPC classification number: A61K8/97 , A61K2800/75 , A61Q7/00 , A61Q19/00
Abstract: A composition for preventing or treating dermatitis is provided to suppress the expression of cytokines such as IL-1alpha, IL-6, IL-8 and MCP-1 (monocyte chemotactic protein) and prevent the dermatitis. A composition for preventing or treating dermatitis comprises Kaempferia pandurata extract as an active ingredient. The Kaempferia pandurata extract inhibits the sebum secretion by decreasing the activation of PPAR-gamma. The Kaempferia pandurata extract is obtained using organic solvent and oil. The skin adhesive cosmetic composition is used in the form of lotion, astringent, massage cream, pack, powder, body lotion, body cream, rinse and shampoo.
Abstract translation: 提供用于预防或治疗皮炎的组合物以抑制细胞因子如IL-1α，IL-6，IL-8和MCP-1（单核细胞趋化蛋白）的表达并预防皮炎。 用于预防或治疗皮炎的组合物包括山梨提取物作为活性成分。 山楂提取物通过降低PPAR-γ的活化来抑制皮脂分泌。 使用有机溶剂和油获得山梨提取物。 皮肤粘合剂化妆品组合物以洗剂，收敛剂，按摩膏，包装，粉末，身体乳液，身体霜，冲洗和洗发剂的形式使用。
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公开(公告)号：KR1020000058514A
公开(公告)日：2000-10-05
申请号：KR1020000031491
申请日：2000-06-08
Applicant: 황재관
IPC: A61K31/045
Abstract: PURPOSE: A method for inhibiting bio-synthesis of cholesterol using xanthorrhizol is provided for use in treating cardiovascular diseases such as arteriosclerosis, hear disease. CONSTITUTION: The Acyl-CoA: Cholesterol Acyltransferase(ACAT) catalyzes the esterification of cholesterol inducing arteriosclerosis, heart attack, and stroke in vivo. The xanthorrhizol to be isolated from Curcuma xanthorrhiza has the structure of formula I and inhibits the activity of Acyl-CoA: Cholesterol Acyltransferase(ACAT). The inhibition activity of ACAT is measured by inhibition percentage of xanthorrhizol or inhibition concentration(50%) IC50, that the concentration inhibits the activity of ACAT by 50% under given conditions, in the presence of 20 nM of ACAT, and is confirmed by animal test, in which after inducing high accumulation of cholesterol, xanthorrhizol is administrated.
Abstract translation: 目的：使用用于抑制胆固醇生物合成的方法，用于治疗心血管疾病如动脉硬化，听到疾病。 构成：酰基辅酶A：胆固醇酰基转移酶（ACAT）催化胆固醇诱导动脉硬化，心脏病发作和体内中风的酯化。 从黄瓜黄疸中分离的黄嘌呤具有式I的结构，并抑制Acyl-CoA：胆固醇酰基转移酶（ACAT）的活性。 通过抑制百分比的抑制浓度（50％）IC 50测量ACAT的抑制活性，在20nM ACAT存在下，浓度在给定条件下将ACAT的活性抑制50％，并由动物确认 测试，其中诱导高胆固醇积累后，给予黄嘌呤。
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公开(公告)号：KR1020000073295A
公开(公告)日：2000-12-05
申请号：KR1019990016507
申请日：1999-05-08
Applicant: 황재관
Abstract: PURPOSE: An anti-biotic active materials from Curcuma xanthorrhiza Roxb. is provided, which is stable at high temperature, shows high anti-biotic activity to the harm mouth microorganisms without side-effects. A mouth cleanser, a toothpaste composition, and gum composition containing the anti-biotic active materials also shows anti-biotic activity without side-effects. CONSTITUTION: A separation process for anti-biotic active materials from Curcuma xanthorrhiza Roxb. comprises of: collecting and drying Curcuma xanthorrhiza Roxb. in the wind, and pulverizing with a mixer; extracting the pulverized Curcuma xanthorrhiza Roxb. reagent with methanol, ethanol, hexane and water(in case of using methanol, ethanol, and hexane as an extracting solvent, mixing each 50vol.%, 75vol.%, 100vol.% of methanol, ethanol and hexane with the reagent, and extracting at room temperature for 2days repeatedly, and in case of using water as an extracting solvent, mixing the reagent with water and extracting at 100°C for 1hr; filtering the extract using a Whatman filter sheath No.2; concentrating the filtered extract with a vacuumed rotatory concentrator to get the extract.
Abstract translation: 目的：来自姜黄黄疸Roxb的抗生物活性物质。 在高温下稳定，对伤口微生物没有副作用，具有较高的抗生物活性。 含有抗生物活性物质的口腔清洁剂，牙膏组合物和牙龈组合物也显示抗生物活性而没有副作用。 构成：姜黄黄疸Roxb抗生物活性物质的分离过程。 包括：收集和干燥姜黄黄疸Roxb。 在风中，用混合机粉碎; 提取粉碎的姜黄黄疸Roxb。 试剂与甲醇，乙醇，己烷和水（在使用甲醇，乙醇和己烷作为萃取溶剂的情况下，用试剂将每个50vol。％，75vol。％，100vol。％的甲醇，乙醇和己烷混合， 在室温下反复2次，在使用水作为提取溶剂的情况下，将试剂与水混合，并在100℃下提取1小时;使用Whatman过滤器鞘2过滤提取物;将过滤的提取物浓缩至 抽真空旋转浓缩器得到提取物。
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公开(公告)号：KR1020000064188A
公开(公告)日：2000-11-06
申请号：KR1020000050229
申请日：2000-08-28
Applicant: 황재관
IPC: A61K36/61 , A61K36/484 , A61P31/04
Abstract: PURPOSE: An antibiotic composition for oral microorganisms using medicinal plant extract is provided, which is low-molecular material and stable at high-temperature; which shows high antibiotic effect without side-effect. CONSTITUTION: A process for the preparation of antibiotic composition for oral microorganisms using medicinal plant extract comprises of: preparing each dried reagent(Baekea frutescens, Glycyrrhiza glabra, Glycyrrhiza uralensis, Kaempferia pandurata, Morus alba, Physalis angulata, or Quercus infectoria); pulverizing each dried reagent to 80mesh, and mixing each reagent 100g with 75% methanol 400ml, and extracting repeatedly for 2times while shaking for 2days; filtering each extracted reagent with Whatman No.2 filter sheath; concentrating each filtered solution under decompression to eliminate solvent ingredient with a vacuumed rotary concentrator; freeze-drying to get each powdered reagent.
Abstract translation: 目的：提供使用药用植物提取物的口服微生物的抗生素组合物，为低分子材料，高温稳定; 表现出高的抗生素效果，无副作用。 构成：使用药用植物提取物制备用于口腔微生物的抗生素组合物的方法包括：制备每种干燥试剂（Baekea frutescens，甘草，甘草，甘草，桑，，Qu ata或栎）。 将每个干燥试剂粉碎至80目，并将每个试剂100g与75％甲醇400ml混合，并振荡2次反复提取2次; 用Whatman No.2过滤护套过滤每个提取的试剂; 在减压下浓缩每个过滤溶液以用真空旋转浓缩器除去溶剂成分; 冷冻干燥得到每种粉末试剂。
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Patent Agency Ranking
公开(公告)号：KR1020080035032A
公开(公告)日：2008-04-23
申请号：KR1020060101089
申请日：2006-10-18
Applicant: 황재관
IPC: A01N65/24
Abstract: A sporicidal agent is provided to inhibit growth and activity of spore-forming food poisoning microorganisms, suppress the exponential growth into feeder cells by inhibiting germination of spores, and inhibit side effects, so that food poisoning is prevented. A sporicidal agent against spore-forming microorganisms contains panduratin A represented by the formula(1) or isopanduratin A represented by the formula(2) which is extracted from Kaempferia pandurata by drying and pulverizing Kaempferia pandurata, extracting the pulverized Kaempferia pandurata with water, methanol, ethanol, ethyl acetate or a mixed solvent thereof, removing solvent from the extract and subjecting the extract to silica gel column chromatography, wherein the spore-forming microorganisms include Bacillus sp. and Clostridium sp.
Abstract translation: 提供灭孢剂以抑制孢子形成的食物中毒微生物的生长和活性，通过抑制孢子的萌发抑制向饲养细胞的指数生长，并抑制副作用，从而防止食物中毒。 针对孢子形成微生物的杀芽孢剂含有由式（1）表示的潘多蛋白A或由通式（2）表示的异万古霉素A，其通过干燥和粉碎山茶来提取，由水提取，用水，甲醇提取粉碎的山茶 乙醇，乙酸乙酯或其混合溶剂，从提取物中除去溶剂，并使提取物进行硅胶柱色谱，其中孢子形成微生物包括芽孢杆菌属。 和梭菌属
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公开(公告)号：KR1020000006939A
公开(公告)日：2000-02-07
申请号：KR1019990050486
申请日：1999-11-13
Applicant: 황재관
Abstract: PURPOSE: An antibacterial soap composition including xanthorrhizol represented by formula 1 is provided which takes antibacterial action for microbes causing dermatitis. CONSTITUTION: The antibacterial soap composition including xanthorrhizol represented by formula 1 is obtained by adding 0.001-5.0 wt% of xanthorrhizol to general soap.
Abstract translation: 目的：提供一种包含由式1表示的黄嘌呤的抗菌皂组合物，其对于引起皮炎的微生物具有抗菌作用。 构成：通过向普通肥皂中加入0.001-5.0重量％的黄嘌呤，得到包含式1所示的黄嘌呤的抗菌皂组合物。
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公开(公告)号：KR1020000000342A
公开(公告)日：2000-01-15
申请号：KR1019990044406
申请日：1999-10-13
Applicant: 황재관
IPC: A23L3/3472
Abstract: PURPOSE: Extraction methods using microwaves, ultrasonic waves, or supercritical fluids are provided to extract an antibiotic material from Curcuma xanthorrhiza which suppresses the growth of a harmful oral germ and a pimple inducible germ. CONSTITUTION: Extraction methods of an antibiotic material are shown: extraction of xanthorrhiza from pulverized Curcuma xanthorrhiza by using CO2 as supercritical fluid, at 35-79°C, and within the range of 100-400 bar; extraction of xanthorrhiza from the composition composed of pulverized Curcuma xanthorrhiza and solvent at the ratio of 10:1-30:1, at 50-120°C for 1-10 min by using microwaves; extraction of xanthorrhiza from the composition composed of pulverized Curcuma xanthorrhiza and solvent at the ratio of 10:1-30:1, at room temperature-50°C for 10-60 min by using ultrasonic waves. The extracts are condensed by evaporating solvents, and are analyzed by using silica gel chromatography.
Abstract translation: 目的：提取使用微波，超声波或超临界流体的提取方法，从姜黄黄疸提取抗生素，抑制有害的口腔细菌和疙瘩诱导型细菌的生长。 构成：抗生素材料的提取方法如下：使用CO2作为超临界流体，在35-79℃，100-400巴的范围内，从粉碎的姜黄中提取黄疸; 通过使用微波从50-120℃以10：1-30：1的比例从粉碎的姜黄和溶剂组成的组合物中提取黄疸1-10分钟; 通过使用超声波在室温-50℃下，以10：1-30：1的比例从粉碎的姜黄和溶剂组成的组合物中提取黄疸10-60分钟。 萃取液通过蒸发溶剂浓缩，并通过硅胶色谱分析。
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公开(公告)号：KR100414548B1
公开(公告)日：2004-01-07
申请号：KR1020000050229
申请日：2000-08-28
Applicant: 황재관
IPC: A61K36/61 , A61K36/484 , A61P31/04
Abstract: PURPOSE: An antibiotic composition for oral microorganisms using medicinal plant extract is provided, which is low-molecular material and stable at high-temperature; which shows high antibiotic effect without side-effect. CONSTITUTION: A process for the preparation of antibiotic composition for oral microorganisms using medicinal plant extract comprises of: preparing each dried reagent(Baekea frutescens, Glycyrrhiza glabra, Glycyrrhiza uralensis, Kaempferia pandurata, Morus alba, Physalis angulata, or Quercus infectoria); pulverizing each dried reagent to 80mesh, and mixing each reagent 100g with 75% methanol 400ml, and extracting repeatedly for 2times while shaking for 2days; filtering each extracted reagent with Whatman No.2 filter sheath; concentrating each filtered solution under decompression to eliminate solvent ingredient with a vacuumed rotary concentrator; freeze-drying to get each powdered reagent.
Abstract translation: 目的：提供一种使用药用植物提取物的口服微生物抗生素组合物，它是低分子材料，在高温下稳定; 其显示出高的抗生素效果而没有副作用。 一种使用药用植物提取物制备用于口腔微生物的抗生素组合物的方法，包括：制备各种干燥的试剂（Baekea frutescens，甘草，甘草，Kaempferia pandurata，桑树，酸Phys或无栎）。 将每种干燥的试剂粉碎至80目，并将各试剂100g与75％甲醇400ml混合，并在振荡2天的同时重复提取2次; 用Whatman No.2过滤套过滤每种提取的试剂; 用减压旋转浓缩器浓缩各过滤溶液以除去溶剂成分; 冷冻干燥以得到每种粉状试剂。
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公开(公告)号：KR1020000054644A
公开(公告)日：2000-09-05
申请号：KR1020000033084
申请日：2000-06-15
Applicant: 황재관
Abstract: PURPOSE: Anti-tooth decaying foods containing xanthorrhizol such as an anti-tooth decaying candy, jelly and chocolate are provided which provide natural taste of foods and effectively prevent a chronic disease of dental caries and similar oral diseases. CONSTITUTION: A anti-tooth decaying foods contain xanthorrhizol represented by the following formula I. The candy composition contains 0.001-1.0 wt.% of the xanthorrhizol. The jelly composition contains 0.001-1.0 wt.% of the xanthorrhizol. The chocolate composition contains 0.001-1.0 wt.% of the xanthorrhizol.
Abstract translation: 目的：提供含有抗菌腐烂糖果，果冻和巧克力的抗菌腐烂食品，提供食物的天然味道，有效预防龋齿和类似口腔疾病的慢性疾病。 构成：抗牙齿腐烂食物含有以下式I表示的黄疸。糖果组合物含有0.001-1.0重量％的黄嘌呤。 果冻组合物含有0.001-1.0重量％的黄嘌呤。 巧克力组合物含有0.001-1.0重量％的黄嘌呤。
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