公开(公告)号：KR101142152B1

公开(公告)日：2012-05-21

申请号：KR1020110010203

申请日：2011-02-01

Applicant: 서울대학교산학협력단

Inventor： 정재민 ,  이영경 ,  이동수 ,  정준기 ,  이명철

IPC: A61K49/18 ,  A61K49/06 ,  B82B3/00 ,  G01N33/58

CPC classification number: A61K51/1244 ,  A61K49/0067 ,  A61K49/0089 ,  G01N33/54346 ,  G01N33/54353 ,  G01N33/54393

Abstract: PURPOSE: A nanoparticle containing a linker which is linked to a long alkane or alkene chain and a method for preparing the same are provided to easily introduce various ligands to the nanoparticles. CONSTITUTION: A nanoparticle containing a linker which is linked to a long alkane or alkene chain has an alkane or alkene part(R) of an alkane or alkene-introduced ligand(R-A-L) of chemical formula 1 coated on the surface of hydrophobic nanoparticles by non-covalent bond. A method for preparing the same comprises: a step of removing organic solvent from the hydrophobic nanoparticles dissolved in the organic solvent or mixing the hydrophobic nanoparticles with the compound of chemical formula 1, PEG derivatives, and a solution containing detergent; and a step of dissolving the mixture.

Abstract translation: 目的：提供含有与长链烷烃或链烯链连接的连接体的纳米粒子及其制备方法，以容易地向纳米粒子引入各种配体。 构成：含有与长链烷烃或链烯链连接的连接体的纳米粒子具有涂覆在疏水性纳米粒子表面上的化学式1的烷烃或烯烃引入配体（RAL）的烷烃或烯烃部分（R） -共价键。 其制备方法包括：从溶解在有机溶剂中的疏水性纳米颗粒中除去有机溶剂或将疏水性纳米颗粒与化学式1的化合物，PEG衍生物和含有洗涤剂的溶液混合的步骤; 和溶解该混合物的步骤。

公开(公告)号：KR101142153B1

公开(公告)日：2012-05-10

申请号：KR1020110010202

申请日：2011-02-01

Applicant: 서울대학교산학협력단

Inventor： 정재민 ,  셰티디네쉬 ,  이동수 ,  정준기 ,  이명철

IPC: C07D255/02 ,  A61K49/06

CPC classification number: C07D255/02 ,  A61K51/044 ,  C07K7/64

Abstract: PURPOSE: A triazanonan derivative and a method for preparing the same are provided to form a complex with metal-fluoride and to be used in various radioactive chemical labelings. CONSTITUTION: A triazanonan derivative for F-18 labeling is denoted by chemical formula 1. An atomic group with biological activity is octreotide, bombesin, vasoactive intestinal peptide(VIP), cholecystokinin, neurotensin, EGF, VEFG, RGD, CXCR4 ligand, substance P or MMP(matrix metalloproteinase). A radioactive chemical used for an imaging device for diagnosis contains the compound of chemical formula 1 and F-18 complex as an active ingredient.

Abstract translation: 目的：提供三唑烷酮衍生物及其制备方法以与金属氟化物形成络合物并用于各种放射性化学标签中。 具有生物学活性的原子团为奥曲肽，铃蟾肽，血管活性肠肽（VIP），胆囊收缩素，神经降压素，EGF，VEFG，RGD，CXCR4配体，物质P 或MMP（基质金属蛋白酶）。 用于诊断成像装置的放射性化学物质含有化学式1和F-18复合物的化合物作为活性成分。