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公开(公告)号：KR101202302B1
公开(公告)日：2012-11-19
申请号：KR1020100040282
申请日：2010-04-29
Applicant: 대한민국(농촌진흥청장) , 동성제약주식회사
Abstract: 본 발명은 봉독을 유효성분으로 함유하는 치주질환 및 충치 예방 및 치료용 조성물에 관한 것으로서, 더욱 상세하게는 충치 유발균, 잇몸 염증 유발균 및 치주질환 유발균에 대한 항균 활성을 가지며, 구강 내 염증을 억제하는 봉독을 유효성분으로 포함하는 치주질환 및 충치 예방 및 치료용 조성물에 관한 것이다.
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公开(公告)号：KR1020120122497A
公开(公告)日：2012-11-07
申请号：KR1020110040687
申请日：2011-04-29
Applicant: 대한민국(농촌진흥청장)
IPC: C12P7/62 , C12N1/14 , A61K31/215 , A61Q19/02
CPC classification number: C12P7/62 , A61K8/33 , A61K31/215 , A61Q19/02 , C12N1/14
Abstract: PURPOSE: A method for producing a large amount of S-dihydroxyfarnesic acid methyl ester is provided to obtain the compound with excellent melanogenesis prevention. CONSTITUTION: A method for producing a large amount melanogenesis inhibitors comprises: a step of culturing insect-derived fungi and preparing a spawn culture medium; a step of inoculating the spawn culture medium to a medium containing a carbon source of glucose, fructose, sucrose, or dextrin and a nitrogen source of tryptone or CSL(corn steep liquor); a step of culturing the mixture. The spawn culture medium is prepared by culturing an insect-derived fungi-inoculated medium at 25-27 Deg. C. for 5-7 days; and a step of inoculating the fungi culture at 160-180 rpm and 25-27 Deg. C. for 3-4 days. A melanogenesis inhibitor contains a melanogenesis inhibiting material, S-(-)-10,11-Dihydroxyfarnesic acid methyl ester.
Abstract translation: 目的：提供大量的S-二羟基法氢酸甲酯的制造方法，以获得预防黑素生成优异的化合物。 构成：生产大量黑素生成抑制剂的方法，包括：培养昆虫来源的真菌并制备产卵培养基的步骤; 将产卵培养基接种到含有葡萄糖，果糖，蔗糖或糊精的碳源和胰蛋白胨或CSL（玉米浆）的氮源的培养基中的步骤; 培养混合物的步骤。 产卵培养基是通过在25-27度培养昆虫来源的真菌接种培养基来制备的。 C. 5-7天; 并以160-180rpm和25-27℃接种真菌培养物的步骤。 C. 3-4天。 黑素生成抑制剂含有黑素生成抑制物质S - （ - ） - 10,11-二羟基法呢酸甲酯。
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公开(公告)号：KR1020120071546A
公开(公告)日：2012-07-03
申请号：KR1020100133134
申请日：2010-12-23
Applicant: 대한민국(농촌진흥청장)
CPC classification number: A61L27/227 , A61F2/0063 , A61L2430/32 , D04H1/09
Abstract: PURPOSE: A silk artificial lipid membrane for artificial cerebral dura mater and biological films are provided to facilitate surgical operation by reinforcing flexibility and improving stability. CONSTITUTION: A silk artificial lipid membrane for artificial cerebral dura mater and biological films comprises the following steps: manufacturing a mixed solution by mixing 0.01-50.00 wt% of salt with 50-99.99wt% of silk fibroin; and manufacturing a silk artificial lipid membrane by pouring the mixed solution into a flat container and desiccating thereof at 20-80 deg. Celsius in a thermostatic chamber which contains 20-80 wt% of moisture. The salt is one of calcium chloride, sodium chloride, potassium chloride, and sodium acetate.
Abstract translation: 目的：提供用于人造脑硬膜和生物膜的丝素人造脂膜，以通过增强弹性和提高稳定性来促进外科手术。 构成：用于人造脑硬膜和生物膜的丝素人造脂膜包括以下步骤：通过将0.01-50.00重量％的盐与50-99.99重量％的丝素蛋白混合制备混合溶液; 并通过将混合溶液倒入平坦容器中并在20-80℃干燥而制造丝状人造脂质膜。 摄氏度在含有20-80重量％水分的恒温槽中。 该盐是氯化钙，氯化钠，氯化钾和乙酸钠之一。
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公开(公告)号：KR1020120067831A
公开(公告)日：2012-06-26
申请号：KR1020100129445
申请日：2010-12-16
Applicant: 대한민국(농촌진흥청장)
Abstract: PURPOSE: A membrane for guiding bone tissue regeneration using silk protein is provided to regenerating bone tissue without inflammation, by having excellent adhesion and biocompatibility. CONSTITUTION: A membrane for guiding bone tissue regeneration comprises: a step of obtaining silk fibroin by removing sericin from silk protein; a step of manufacturing silk fibroin salt ethanol solution by dissolving the silk fibroin in to ethanol solution with salt; a step of manufacturing silk fibroin solution by removing salt and ethanol from the silk fibroin solution; and a step of drying the silk fibroin solution into a flat container. The silk fibroin solution contains 0.5-20 weight% of silk fibroin. The salt is one selected from bromide salt,, lithium chloride, zinc chloride, calcium chloride, and calcium nitrate.
Abstract translation: 目的：提供用于使用丝蛋白引导骨组织再生的膜，通过具有优异的粘附性和生物相容性来再生骨组织而不发炎。 构成：用于引导骨组织再生的膜包括：通过从丝蛋白中去除丝胶蛋白获得丝素蛋白的步骤; 通过将丝素蛋白溶解于乙醇溶液中制备丝素蛋白盐水乙醇溶液的步骤; 通过从丝素蛋白溶液中除去盐和乙醇来制造丝素蛋白溶液的步骤; 以及将丝素蛋白溶液干燥成扁平容器的步骤。 丝素蛋白溶液含有0.5-20重量％的丝素蛋白。 该盐选自溴化物盐，氯化锂，氯化锌，氯化钙和硝酸钙。
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公开(公告)号：KR1020110080383A
公开(公告)日：2011-07-13
申请号：KR1020100000564
申请日：2010-01-05
Applicant: 대한민국(농촌진흥청장)
Abstract: PURPOSE: A composition containing bee venom for preventing and treating neurodegenerative diseases is provides to suppress amyloid accumulation. CONSTITUTION: A composition for preventing and treating neurodegenerative diseases contains bee venom as an active ingredient. The neurodegenerative diseases are dementia, Alzheimer's disease, or stroke. A functional food for preventing and treating neurodegenerative diseases contains 0.0001-10%(w/v) of bee venom as an active ingredient. The composition is manufactured in the form of oral formulation or parenteral formulation.
Abstract translation: 目的：用于预防和治疗神经变性疾病的含有蜂毒的组合物用于抑制淀粉样蛋白积聚。 构成：用于预防和治疗神经变性疾病的组合物含有蜂毒作为活性成分。 神经变性疾病是痴呆，阿尔茨海默病或中风。 用于预防和治疗神经变性疾病的功能性食品含有0.0001-10％（w / v）的蜂毒作为活性成分。 组合物以口服制剂或非肠道制剂的形式制备。
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Patent Agency Ranking
公开(公告)号：KR101018352B1
公开(公告)日：2011-03-04
申请号：KR1020090068925
申请日：2009-07-28
Applicant: 대한민국(농촌진흥청장) , 동성제약주식회사
Abstract: 본 발명은 여드름을 유발시키는 원인균으로 알려진 프로피오니박테리움 아크네스(
Propionibacterium acnes )에 대하여 항균 작용이 우수하고, 또한 염즘 발생 부위를 더욱 확장시켜, 여드름이 악화되는데 영향을 주는 피부 상재균에도 강한 항균 작용을 보이며, 여드름으로 인해 손상된 피부세포의 재생을 돕는 우수한 물질을 포함한 여드름 예방 및 치료용 조성물에 관한 것으로, 본 발명의 조성물은 봉독(벌침액,
Apis
meliffera )을 포함하며 이를 화장료 또는 비누화 하거나 의약품으로서 연고, 벤드, 드레싱 형태 등의 피부 외용제로서 여드름을 원인적으로 예방·치료하기 위한 여드름 치료제 조성물에 관한 것이다.-
公开(公告)号：KR1020100121169A
公开(公告)日：2010-11-17
申请号：KR1020090040200
申请日：2009-05-08
Applicant: 한림대학교 산학협력단 , 대한민국(농촌진흥청장)
CPC classification number: A61L27/3641 , A61F2/18 , A61F11/00 , A61F2002/183 , A61L27/3604 , A61L27/38 , A61L2430/14
Abstract: PURPOSE: An artificial eardrum using a silk protein and a method for manufacturing the same are provided to have strengths in bio compatibility and transparency. CONSTITUTION: An artificial eardrum using a silk protein comprises a silk film shape by desalinating and drying silk protein or silk protein compound solution obtained after removing ceracin from cocoons or fibroin Silk protein or silk protein compound solution are dissolved using chaotropic salt or one compound of bromination lithium, lithium chloride, zinc chloride, or calcium chloride. At least one additive of gelatin, collagen, chitosan, alginic acid, hyaluronic acid, pluronic 127 or PEG is added to the silk film.
Abstract translation: 目的：提供使用丝蛋白的人造耳膜及其制造方法，以具有生物相容性和透明度的优点。 构成：使用丝蛋白的人造鼓膜包括通过脱盐和干燥从茧或丝心蛋白中除去ceracin后获得的丝蛋白或丝蛋白复合溶液的丝膜形状丝蛋白或丝蛋白复合溶液使用离液盐或一种溴化化合物溶解 锂，氯化锂，氯化锌或氯化钙。 将至少一种明胶，胶原，壳聚糖，海藻酸，透明质酸，pluronic 127或PEG的添加剂加入到丝膜中。
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公开(公告)号：KR1020100110129A
公开(公告)日：2010-10-12
申请号：KR1020090028544
申请日：2009-04-02
Applicant: 대한민국(농촌진흥청장)
CPC classification number: A61L26/0057 , A61F2013/00157 , A61F2013/00391 , A61F2013/00919 , A61K8/987 , A61K9/0014 , A61K9/06 , A61K9/7023 , A61K35/63 , A61K47/44 , A61L15/40 , A61Q17/04 , A61Q19/08 , Y02A50/473
Abstract: PURPOSE: A composition for healing wound or treating burn is provided to promote skin cell regeneration and to ensure antibacterial effect. CONSTITUTION: A composition for healing wound or treating burn contains 0.001-10%(w/v) of bee venom as an active ingredient. The composition additionally contains bio-absorbable particle or fiber such as a gel matrix to help lesion application and bee venom absorption. The gel matrix is alginate or hyaluronic acid. The composition is formulated in dressing agent, ointment, or patch. An external use skin formulation contains bee venom as an active ingredient. A cosmetic product for anti-wrinkle or UV protection contains bee venom as an active ingredient.
Abstract translation: 目的：提供用于治疗伤口或治疗烧伤的组合物，以促进皮肤细胞再生并确保抗菌效果。 构成：用于治疗伤口或治疗烧伤的组合物含有0.001-10％（w / v）的蜂毒作为活性成分。 该组合物还含有生物可吸收颗粒或纤维如凝胶基质，以帮助病变应用和蜂毒吸收。 凝胶基质是藻酸盐或透明质酸。 该组合物配制在敷料剂，软膏剂或贴剂中。 外用皮肤制剂含有蜂毒作为活性成分。 抗皱或紫外线防护用化妆品含有蜂毒作为活性成分。
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公开(公告)号：KR1020100088389A
公开(公告)日：2010-08-09
申请号：KR1020090007580
申请日：2009-01-30
Applicant: 대한민국(농촌진흥청장) , 주식회사 청진바이오텍
Abstract: PURPOSE: A natural antibiotics containing bee venom and herb extract is provided to ensure high disinfection effect and to treat disease of piglet. CONSTITUTION: A natural antibiotics contains bee venom and herb extract as an active ingredient. The herb extract is obtained from Houttuynia cordata, Artemisia capillaris Thunb, green tea leaves. The natural antibiotics contains 0.01-5 weight% of bee venom, 5-20 weight% of herb extract, and 75-95 weight% of solvent.
Abstract translation: 目的：提供含有蜂毒和草药提取物的天然抗生素，以确保高消毒效果和治疗小猪疾病。 构成：天然抗生素含有蜂毒和草药提取物作为活性成分。 草药提取物由鱼腥草，青蒿，绿茶叶获得。 天然抗生素含有0.01-5重量％的蜂毒，5-20重量％的草药提取物和75-95重量％的溶剂。
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公开(公告)号：KR1020090036758A
公开(公告)日：2009-04-15
申请号：KR1020070101980
申请日：2007-10-10
Applicant: 대한민국(농촌진흥청장) , 동성제약주식회사
CPC classification number: A61K35/63 , A61K38/012
Abstract: A composition for preventing and treating osteoporosis comprising silk peptide as an active ingredient is provided to suppress the differentiation of osteoclast by using natural protein. A composition for preventing and treating osteoporosis comprises silk peptide as an active ingredient. The silk peptide is an acid of silk or hydrolysate of enzyme. The silk peptide is the pyrolysate of cocoon containing sericin. An amino acid composition of the silk peptide are 80 weight% or greater based on the total content of glycine 40-45 weight%, alanine 20-30 weight% and serine 10-20 weight%.
Abstract translation: 提供一种用于预防和治疗包含丝肽作为活性成分的骨质疏松症的组合物，以通过使用天然蛋白质来抑制破骨细胞的分化。 用于预防和治疗骨质疏松症的组合物包括丝肽作为活性成分。 丝肽是丝的酸或酶的水解产物。 丝肽是含有丝胶蛋白的茧的热解物。 基于甘氨酸40-45重量％，丙氨酸20-30重量％和丝氨酸10-20重量％的总含量，丝肽的氨基酸组成为80重量％以上。
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