公开(公告)号：KR1020130097589A

公开(公告)日：2013-09-03

申请号：KR1020120019345

申请日：2012-02-24

Applicant: 대한민국(농촌진흥청장)

Inventor： 한상익 ,  장기창 ,  서우덕 ,  나지은 ,  오성환 ,  최경진 ,  강항원

IPC: C09B61/00 ,  C09B67/54

CPC classification number: C09B61/00 ,  A23L33/105 ,  A61K8/97 ,  A61Q17/005

Abstract: PURPOSE: A natural pigment using a sorghum byproduct contains a functional active component such as anti-oxidation, anti-inflammation, and antibacterial and maintain inherent colors for a long time and having excellent storage stability according to pH conditions. CONSTITUTION: A natural pigment extract of a sorghum byproduct with anti-oxidation and antibacterial activity is obtained by pulverizing the sorghum byproduct and extracting the pulverized material of the sorghum byproduct by a lower alcohol under the presence of an acid. The lower alcohol is methanol or ethanol. The byproduct is a leaf or a stem of sorghum. The acid is selected from hydrochloric acid, the citric acid, and the acetic acid, and malic acid. An anti-oxidation and antibiotic cosmetic composition, a pharmaceutical composition, and food additives contain the natural pigment extract as an active ingredient. [Reference numerals] (AA) Extract amount mg/100g; (BB) Natural pigment content [mg/100g]; (CC,DD) Ethanol ratio

Abstract translation: 目的：使用高粱副产品的天然色素含有抗氧化，抗炎，抗菌等功能活性成分，长时间保持固色，根据pH条件具有良好的储存稳定性。 构成：通过粉碎高粱副产物并在酸的存在下通过低级醇提取高粱副产物的粉碎物质，获得具有抗氧化和抗菌活性的高粱副产物的天然色素提取物。 低级醇是甲醇或乙醇。 副产品是高粱的叶子或茎。 酸选自盐酸，柠檬酸，乙酸和苹果酸。 抗氧化和抗生素化妆品组合物，药物组合物和食品添加剂含有天然色素提取物作为活性成分。 （AA）提取量mg / 100g; （BB）天然色素含量[mg / 100g]; （CC，DD）乙醇比例

公开(公告)号：KR101296209B1

公开(公告)日：2013-08-20

申请号：KR1020120081945

申请日：2012-07-26

Applicant: 대한민국(농촌진흥청장) ,  경북대학교 산학협력단

Inventor： 한상익 ,  장기창 ,  서우덕 ,  나지은 ,  오성환 ,  최경진 ,  강항원 ,  남민희 ,  염정현 ,  현재민

IPC: D01F1/10 ,  D01F4/00 ,  D01D1/02 ,  D01D5/00 ,  A61K8/02 ,  A61K8/64 ,  A45D44/22 ,  A61K8/34

CPC classification number: D01F1/103 ,  A45D44/22 ,  A61K8/0212 ,  A61K8/347 ,  A61K8/64 ,  D01D1/02 ,  D01D5/0015 ,  D01F4/00

Abstract: PURPOSE: Zein nanofiber which contains sorghum extract is provided to show high antibiosis and be used in the field of medical treatment and beauty treatment due to no cytotoxicity. CONSTITUTION: A manufacturing method of Zein nanofiber that has wrinkled nanofiber surface containing sorghum extract to improve heat-resisting and antibiotic comprises the manufacturing step of spinning solution and a step of electric radiation. The step of manufacturing spinning solution manufactures the blend solution by dissolving Zein which is a native protein extracted from corns, sorghum, and the sorghum byproduct extract in the solution. The electric radiation step electrically radiates the spinning solution. The extract of the sorghum or the sorghum byproduct is characterized as being the golden Sorghum bicolor L. Moench extract. The sorghum byproduct extract is characterized as being the golden sorghum stem extract and the golden sorghum leaf extract. The component of the sorghum extract and the sorghum byproduct extract is chemical formula 1 or chemical formula 2. Mask sheet which has non-uniform nanofiber surface for improving heat resistance and antibiotic comprises Zein nanofiber which contains sorghum extract manufactured by the electric radiation on the top portion of the nonwoven fabric of the mask sheet.

Abstract translation: 目的：提供含有高粱提取物的Zein纳米纤维，以显示高抗菌性，并且由于没有细胞毒性而用于医疗和美容治疗领域。 构成：含有高粱提取物的纳米纤维表面起皱以提高耐热性和抗生素的Zein纳米纤维的制造方法包括纺丝溶液的制造步骤和电辐射步骤。 制造纺丝溶液的步骤通过将玉米，高粱和高粱副产物提取物中提取的天然蛋白质的Zein溶解在溶液中来制造混合溶液。 电辐射步骤电纺丝纺丝溶液。 高粱或高粱副产品的提取物的特征在于是金色高粱双色L.Moench提取物。 高粱副产品提取物的特征是金高粱茎提取物和金黄高粱叶提取物。 高粱提取物和高粱副产物提取物的组分是化学式1或化学式2.具有不均匀纳米纤维表面以提高耐热性和抗生素的掩模片包括含有通过顶部电辐射制造的高粱提取物的玉米素纳米纤维 掩模片无纺布的一部分。

公开(公告)号：KR1020130076558A

公开(公告)日：2013-07-08

申请号：KR1020110145189

申请日：2011-12-28

Applicant: 대한민국(농촌진흥청장)

Inventor： 나지은 ,  서우덕 ,  장기창 ,  한상익 ,  최경진 ,  강항원 ,  오성환 ,  김상열

IPC: A61K36/899 ,  A61K31/37 ,  A61K31/35 ,  A61P31/12

CPC classification number: A61K31/352 ,  A61K36/899 ,  A61K2236/33

Abstract: PURPOSE: A composition containing a natural pigment extract of sorghum or polyphenol compounds such as apigenin, apigeninidine, luteolin, and luteolinidine is provided to suppress neuraminidase activity, and to be used as a pharmaceutical product, a food additive, or a feed additive with antibacterial or antiviral activity. CONSTITUTION: A pharmaceutical composition as an antibacterial agent or an antiviral agent contains a natural pigment extract of sorghum and suppresses neuraminidase. The pharmaceutical composition contains one or more kinds of polyphenol compounds selected among apigenin of chemical formula 1, apigeninidine of chemical formula 2, luteolin of chemical formula 3, and luteolinidine of chemical formula 4. A food additive with antibacterial or antiviral activity contains the one or more kinds of polyphenol compounds as active ingredients. A method for preparing the extract comprises the step of extracting sorghum powder with a methanol solvent containing 0.1-1% of hydrochloric acid at 5-40 deg. C.

Abstract translation: 目的：提供含有高粱或多酚化合物的天然色素提取物如芹菜素，芹菜碱，木犀草素和黄嘌呤苷的组合物以抑制神经氨酸酶活性，并用作药物产品，食品添加剂或具有抗菌性的饲料添加剂 或抗病毒活性。 构成：作为抗菌剂或抗病毒剂的药物组合物含有高粱的天然色素提取物，抑制神经氨酸酶。 药物组合物含有选自化学式1的芹菜素，化学式2的芹菜碱，化学式3的木犀草素和化学式4的木犀草素的一种或多种多酚化合物。具有抗菌或抗病毒活性的食品添加剂包含一种或多种 多种多酚化合物作为活性成分。 制备提取物的方法包括在5-40度下用含0.1-1％盐酸的甲醇溶剂萃取高粱粉的步骤。 C。

公开(公告)号：KR1020120102473A

公开(公告)日：2012-09-18

申请号：KR1020110020660

申请日：2011-03-08

Applicant: 대한민국(농촌진흥청장)

Inventor： 장기창 ,  한상익 ,  서우덕 ,  나지은 ,  오성환 ,  최경진 ,  강항원 ,  하태정

IPC: A61K36/8998 ,  A61K31/37 ,  A61P31/16 ,  A61P31/00

CPC classification number: A61K31/352 ,  A61K36/8998 ,  A61K2236/333 ,  A61K2236/55 ,  Y10S514/888

Abstract: PURPOSE: A polyphenol compound and young barley leaf extract with an effect of suppressing neuraminidase is provided to release generated virus into the outside of cells and to strongly suppress neuraminidase. CONSTITUTION: A pharmaceutical composition for preventing or treating influenza virus contains young barley leaf extract as an active ingredient and suppresses neuraminidase. The pharmaceutical composition contains a compound selected from compounds of chemical formulas 1-7. The extract is prepared using alcohol of 1-4 carbon atoms. The young barley is prepared by harvesting buds 5-15 days after sprouting and freeze-drying. A pharmaceutical composition for preventing or treating influenza virus contains the compound.

Abstract translation: 目的：提供具有抑制神经氨酸酶作用的多酚化合物和年轻大麦叶提取物，将产生的病毒释放到细胞外，强烈抑制神经氨酸酶。 构成：用于预防或治疗流感病毒的药物组合物含有年轻的大麦叶提取物作为活性成分并抑制神经氨酸酶。 药物组合物含有选自化学式1-7的化合物的化合物。 提取物是使用1-4个碳原子的醇制备的。 幼芽通过在发芽和冷冻干燥后5-15天收获芽来制备。 用于预防或治疗流感病毒的药物组合物含有该化合物。

公开(公告)号：KR101483589B1

公开(公告)日：2015-01-19

申请号：KR1020110116385

申请日：2011-11-09

Applicant: 대한민국(농촌진흥청장)

Inventor： 서우덕 ,  장기창 ,  한상익 ,  김상열 ,  오성환 ,  나지은 ,  최경진 ,  이기환 ,  송유천 ,  강항원

IPC: A61K36/8998 ,  A61P3/10 ,  A61P3/00

Abstract: 본 발명은 새싹보리 유래 폴리코사놀 성분인 헥사코사놀, 옥타코사놀 등의 폴리코사놀의 함량이 높은 추출물 및 그의 제조 방법에 관한 것으로, 보다 상세하게는 본 추출방법은 보리를 품종별로 파종하여 발아시켜 길이가 15∼25cm 전후로 될 때 뿌리를 제외한 지상부를 수확하여 건조, 분쇄하여 헥산 또는 주정으로 추출, 농축 및 유기용매를 진공에서 제거하는 것을 특징으로 하여, 고농도의 헥사코사놀, 옥타코사놀 등의 폴리코사놀을 함유하는 추출물을 제조하는 방법과 최적 수확시기, 최적추출방법 및 보리품종 선발에 관한 것이다. 헥사코사놀, 옥타코사놀 등의 폴리코사놀은 콜레스테롤 개선, 항동맥경화, 항당뇨, 항혈전, 항균활성, 지구력 강화 및 기능성 화장료로 효과가 있음이 알려져 있다.
또한, 새싹보리 유래 헥산 추출물에 대한 헥사코사놀, 옥타코사놀 등의 폴리코사놀의 구성성분에 대한 정량분석 과 AMP(Adenosine monophosphate)Kinase 인산화 활성 단백질의 발현 검정 등을 수행하였으며 새싹보리의 헥사코사놀, 옥타코사놀 및 폴리코사놀을 함유하는 추출물을 이용한 조성물들은 콜레스테롤 개선, 항동맥경화, 당뇨, 항균, 혈전용해, 피부활력 증가 및 지구력증진 등의 건강 기능성 식품, 기능성 화장품 등의 원료 및 제품 등에 이용될 수 있다.

公开(公告)号：KR1020140065657A

公开(公告)日：2014-05-30

申请号：KR1020120131142

申请日：2012-11-19

Applicant: 대한민국(농촌진흥청장) ,  공주대학교 산학협력단

Inventor： 박윤제 ,  한상익 ,  서우덕 ,  나지은 ,  장기창 ,  오성환 ,  최경진 ,  조준현 ,  강현중 ,  이종희 ,  남민희

IPC: C12N1/14 ,  A23L7/10

CPC classification number: A23L7/104 ,  A23L5/30 ,  A23V2002/00 ,  C12N1/14

Abstract: 본발명은홍국균에대하여 UV-C 조사와 NTG를조사하여모나콜린 K를다량생산하고시트리닌을생산하지않는홍국균(Monascus) 변이주ACEP-1 KACC 93162P 및이를쌀에접종시켜배양한홍국미에관한것이다. 본발명의홍국균(Monascus) 변이주ACEP-1 KACC 93162P는종래의홍국균변이주대비모나콜린 K의생산성이뛰어나며, 오렌지색및 적색의색소생산능이있어색소관련분야에도이용가능하다.

Abstract translation: 本发明涉及红曲霉突变菌株红曲霉ACEP-1 KACC 93162P，涉及接种红曲霉ACEP-1 KACC 93162P的栽培红酵母水稻。 红曲霉突变株红曲霉ACEP-1 KACC 93162P通过UV-C和NTG暴露突变，大量产生莫纳可林K，不产生柑橘素。 根据本发明，红曲霉突变菌株Monascusruber ACEP-1 KACC 93162P具有优异的莫纳可林K的生产率和颜料生产能力，因此可用于与颜料相关的领域。

公开(公告)号：KR1020130051181A

公开(公告)日：2013-05-20

申请号：KR1020110116385

申请日：2011-11-09

Applicant: 대한민국(농촌진흥청장)

Inventor： 서우덕 ,  장기창 ,  한상익 ,  김상열 ,  오성환 ,  나지은 ,  최경진 ,  이기환 ,  송유천 ,  강항원

IPC: A61K36/8998 ,  A61P3/10 ,  A61P3/00

Abstract: PURPOSE: An extract with high content of barley sprout-derived policosanol, and a method for preparing the same are provided to produce health functional food and a functional cosmetic product for treating cholesterol, arteriosclerosis, and diabetes with antibacterial property, thrombolysis, and skin vitality. CONSTITUTION: A pharmaceutical composition for preventing and treating cholesterol, arteriosclerosis, or diabetes contains a barley sprout extract as an active ingredient, and activates phosphorylation of AMPK(Adenosine monophosphate kinase). The pharmaceutical composition contains a compound selected among compound denoted by chemical formulas 1-9. A method for preparing the compounds denoted by the chemical formulas comprises: a step of freeze-drying barley sprouts and pulverizing; a step of extracting the barley sprouts with C1-C4 alcohol or n-hexane; a step of adding water and suspending; a step of adding an organic solvent, and obtaining each fraction; and a step of eluting the fraction on a silicagel column.

Abstract translation: 目的：提供大麦芽衍生的二十烷醇含量高的提取物及其制备方法，以制备健康功能食品和用于治疗胆固醇，动脉硬化和糖尿病的功能性化妆品，具有抗菌性，溶栓作用和皮肤活力 。 构成：用于预防和治疗胆固醇，动脉硬化或糖尿病的药物组合物含有大麦芽提取物作为活性成分，并激活AMPK（腺苷单磷酸激酶）的磷酸化。 该药物组合物含有选自化学式1-9表示的化合物的化合物。 由化学式表示的化合物的制备方法包括：冷冻干燥大麦芽和粉碎的步骤; 用C1-C4醇或正己烷萃取大麦芽的步骤; 加水和暂停的一个步骤; 加入有机溶剂，得到各部分的工序; 以及在硅胶柱上洗脱级分的步骤。