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公开(公告)号：KR1020150049540A
公开(公告)日：2015-05-08
申请号：KR1020130130230
申请日：2013-10-30
Applicant: 서울대학교산학협력단
Abstract: 본발명은분광표지및 시각적으로인식가능한그래픽표지를가진이중표지마이크로디스크, 및그를이용한복수의타겟바이오물질의검출방법에관한것으로, 그래픽표지입자크기를줄이면서라만산란표지와이중으로사용하고, 또한타겟바이오물질과결합가능한리셉터를그래픽표지입자외에별도의마이크로비드에결합시킴으로써, 다중검출방법에활용하기에제한점이되었던그래픽입자의크기문제를해결하여, 복수의타겟바이오물질의검출이가능하게한다.
Abstract translation: 本发明涉及一种具有光谱覆盖和视觉识别的图形标记的双标记微盘，以及通过使用该多重目标生物材料来检测多个目标生物材料的方法。 当图形标记粒子的尺寸减小时，双重使用拉曼散射标记。 此外，可以与目标生物材料结合的受体与图形标记颗粒以外的单独的微珠结合。 因此，解除了当用于多检测方法时引起限制的图形粒子的尺寸的问题，从而允许检测多个目标生物材料。
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公开(公告)号：KR101358729B1
公开(公告)日：2014-02-24
申请号：KR1020120040994
申请日：2012-04-19
Applicant: 서울대학교산학협력단
IPC: B82B1/00 , G01N33/574 , A61B5/00 , G01N21/65
Abstract: 본 발명은 실리카 중심 입자; 및 상기 실리카 중심 입자 주변을 둘러싸고 있는 할로우 금속 나노입자층;을 포함하여 이루어진 근적외선 광학영상용 나노-표지 입자, 그 제조방법 및 그를 이용한 생체 내 광학 검출방법에 관한 것으로, 본 발명은 근적외선 광학영상용 나노-표지 입자는 근적외선 영역의 파장을 이용하여 생체 내, 예를 들어 피하 조직의 광학영상을 확인할 수 있고, 표면증강 라만산란 강도가 뛰어나며, 생체적합성 및 안정성이 뛰어나므로, 생체 내 다중 광학영상을 얻기 위한 나노 프로브로서 활용될 수 있다.
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Patent Agency Ranking
公开(公告)号：KR1020130127365A
公开(公告)日：2013-11-22
申请号：KR1020130046310
申请日：2013-04-25
Applicant: 서울대학교산학협력단
CPC classification number: G01N33/56983 , A61B8/0808 , A61K9/5068 , A61K9/5169 , B82Y15/00 , B82Y30/00 , G01N33/54373 , G01N33/56911 , G01N33/56961 , G01N33/587
Abstract: A nanoprobe based on biomass for enabling self-duplication comprises: a combining element which exists in a first area of the biomass and is able to be unusually coupled to a target substance; and nanoparticles which exist in a second area of the biomass and provide an optical detection signal. The nanoprobe enables the quantitative analysis and multiplexed analysis of the target substance and facilitates mass production.
Abstract translation: 基于用于实现自重复的生物质的纳米探针包括：存在于所述生物质的第一区域中并能够非常偶联于目标物质的组合元件; 和存在于生物质的第二区域中并提供光学检测信号的纳米颗粒。 纳米探针能够对目标物质进行定量分析和多重分析，并促进批量生产。
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公开(公告)号：KR1020130118086A
公开(公告)日：2013-10-29
申请号：KR1020120040994
申请日：2012-04-19
Applicant: 서울대학교산학협력단
IPC: B82B1/00 , G01N33/574 , A61B5/00 , G01N21/65
CPC classification number: G01N33/587 , A61B5/00 , B82Y5/00 , B82Y20/00 , B82Y40/00 , G01N21/65 , G01N33/574
Abstract: PURPOSE: A nano-tagging particle for near infrared optical image is provided to check the in vivo optical image using a spectrum range of near infrared ray, and to have the excellent enrichment Raman scattering intensity, biocompatibility, and stability. CONSTITUTION: A nano-tagging particle for near infrared optical image comprises a silica core particle and a hollow metal nanoparticle layer surrounding the silica core particle. The average particle size of the silica core particle is 50-300 nm. The hollow metal nanoparticle is a hollow metal nanosphere. The hollow metal nanoparticle is a hollow gold nanoparticle, a hollow gold, and a silver nanoparticle. The surface of the hollow metal nanoparticle in the hollow metal nanoparticle layer is coated with a marker. A manufacturing method of the nano-tagging particle for near infrared optical image is as follows. The silica core particle is manufactured. The silver nanoparticle layer is formed on the surface of the silica core particle. The silica particle, in which the silver nanoparticle layer is formed, is reacted with gold ion so that the silica particle, in which the hollow gold and the silver nanoparticle layer are formed by Galvanic displacement reaction, is manufactured.
Abstract translation: 目的：提供近红外光学图像的纳米标记粒子，利用近红外光谱范围检测体内光学图像，具有优异的富集拉曼散射强度，生物相容性和稳定性。 构成：用于近红外光学图像的纳米标签颗粒包括二氧化硅核心颗粒和围绕二氧化硅核心颗粒的中空金属纳米颗粒层。 二氧化硅核粒子的平均粒径为50〜300nm。 中空金属纳米颗粒是中空金属纳米球。 中空金属纳米颗粒是中空金纳米颗粒，中空金和银纳米颗粒。 中空金属纳米颗粒层中的中空金属纳米颗粒的表面涂有标记物。 用于近红外光学图像的纳米标签颗粒的制造方法如下。 制造二氧化硅核心颗粒。 在二氧化硅核心颗粒的表面上形成银纳米粒子层。 其中形成有银纳米颗粒层的二氧化硅颗粒与金离子反应，从而制造通过电位移反应形成中空金和银纳米颗粒层的二氧化硅颗粒。
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26.发明公开형광 및 라만 신호 표적에 대한 형광 및 라만 신호 동시검출방법 및 이를 이용한 표적 동시검출용 의학영상장치 有权使用荧光和拉曼信号同时检测多重目标的医学成像方法和装置同时检测使用其的荧光和拉曼信号的多个目标
公开(公告)号：KR1020120015227A
公开(公告)日：2012-02-21
申请号：KR1020100077565
申请日：2010-08-11
Applicant: 서울대학교산학협력단
CPC classification number: A61B5/0071 , A61B1/00165 , A61B1/00172 , A61B1/00186 , A61B1/015 , A61B1/043 , A61B1/063 , A61B1/126 , A61B5/0062 , A61B5/0068 , A61B5/0075 , A61B5/0084 , A61K49/0065 , B82Y30/00
Abstract: PURPOSE: A medical imaging method for simultaneous detection of multiplex targets using a fluorescent and a raman signal and an apparatus for simultaneously detecting multiplex targets of fluorescent and raman signal using thereof are provided to obtain more accurate diagnosis result in real time. CONSTITUTION: A light source(10) projects a laser light. An image guide part(21) guides the optical signal of an incident light emitted from a surface particle. A scanner(30) scans the optical signal collected from an optical collection unit(20). A light division unit includes a beam splitter projecting the incident light through a first path and a second path. A fluorescence signal detection unit detects a fluorescence signal from an optical signal in the first path.
Abstract translation: 目的：提供使用荧光和拉曼信号同时检测多重目标的医学成像方法和用于同时检测使用其的荧光和拉曼信号的多重目标的装置，以实时获得更准确的诊断结果。 构成：光源（10）投射激光。 图像引导部（21）引导从表面粒子发射的入射光的光信号。 扫描器（30）扫描从光学收集单元（20）收集的光学信号。 光分割单元包括通过第一路径和第二路径投影入射光的分束器。 荧光信号检测单元从第一路径中的光信号检测荧光信号。
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公开(公告)号：KR1020100102273A
公开(公告)日：2010-09-24
申请号：KR1020090020563
申请日：2009-03-11
Applicant: 서울대학교산학협력단
IPC: G01N33/52 , G01N33/533
Abstract: PURPOSE: A qualitative method of a multiple marker is provided to performing qualitation of high sensitivity and selectivity using F-SERS dots. CONSTITUTION: A qualitative method for a multiple marker comprises: a step of treating multiple marker-specific fluorescence-surface enhanced raman scattering(SERS) dot mixture to a sample; and a step of measuring raman signal corresponding to the multiple marker to calculate relative amount of the multiple marker. The SERS dot comprises: a metal nanoparticle layer containing a metal on the surface of silica nanoparticle; a raman probe and fluorescence probe layer formed at the metal nanoparticle layer; a functional layer; and a reaction molecule attached on the functional layer. The diameter of the silica nanoparticle is 50-300nm. The metal is gold, silver, palladium, platinum, aluminum, iridium, osmium, rhodium or ruthenium. The functional group is thiol group(-SH), amine group(-NH_2) or carboxyl group(-COOH).
Abstract translation: 目的：提供多重标记的定性方法，以使用F-SERS点进行高灵敏度和选择性的定性。 构成：多重标记的定性方法包括：将多个标记特异性荧光表面增强拉曼散射（SERS）点混合物处理到样品的步骤; 以及测量与所述多个标记相对应的拉曼信号以计算所述多个标记的相对量的步骤。 SERS点包括：在二氧化硅纳米颗粒的表面上含有金属的金属纳米颗粒层; 在金属纳米颗粒层形成的拉曼探针和荧光探针层; 功能层; 和附着在功能层上的反应分子。 二氧化硅纳米颗粒的直径为50-300nm。 金属是金，银，钯，铂，铝，铱，锇，铑或钌。 官能团是硫醇基（-SH），胺基（-NH2）或羧基（-COOH）。
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公开(公告)号：KR1020100083495A
公开(公告)日：2010-07-22
申请号：KR1020090002902
申请日：2009-01-14
Applicant: 서울대학교산학협력단
IPC: G01N33/53 , C12Q1/02 , G01N33/574
Abstract: PURPOSE: A method for isolating cells using M-SERS dots(Magnetic surface enhanced raman spectroscopic dots) is provided to isolated rare cells in organs. CONSTITUTION: A method for isolating cells comprises: a step of treating a sample with antibody-conjugated M-SERS dots; a step of applying magnetic force to collect marker-positive cells; and a step of performing FACS(Fluorescence activated cell sorter) to isolate target cells from the collected cells. The target cells are cancer stem cells. The cancer stem cells are BASCs(bronchioalveolar stem cells) and the marker is CD34.
Abstract translation: 目的：使用M-SERS点（磁性表面增强拉曼光谱点）分离细胞的方法提供给器官中的分离的稀有细胞。 构成：分离细胞的方法包括：用抗体缀合的M-SERS点处理样品的步骤; 施加磁力以收集标记阳性细胞的步骤; 以及进行FACS（荧光活化细胞分选仪）从收集的细胞中分离靶细胞的步骤。 靶细胞是癌干细胞。 癌干细胞是BASC（支气管肺泡干细胞），标记物是CD34。
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