公开(公告)号：KR101527283B1

公开(公告)日：2015-06-10

申请号：KR1020130095978

申请日：2013-08-13

Applicant: 서울대학교산학협력단

Inventor： 김영수 ,  윤정환 ,  김현수 ,  김경곤 ,  진종화

IPC: C12Q1/68 ,  G01N33/68 ,  G01N33/48

CPC classification number: G01N33/57469 ,  G01N33/57438 ,  G01N33/6848 ,  G01N2033/57461 ,  G01N2400/00

Abstract: 본원은 N-연결당화 (N-linked glycosylation) 모티브를포함하는단백질에서탈당화펩타이드단편및 비당화펩타이드단편의비율을이용한암 진단마커의스크리닝방법, 이에의해선별된마커, 및상기마커를이용한암 진단또는예후분석용조성물및 키트를개시한다. 본원의방법은기존마커보다정확도및 특이도가보다높은암관련마커의발굴이가능하다. 또한이를통해서발굴된바이오마커는높은정확도와민감도로암의조기진단, 모니터링및 질병정도를혈액을이용한비침습성검사로간단하고유효성있는암의진단또는모니터링이가능하여, 암조기발견은물론암의치료여부및 치료경과확인에도유용하게사용될수 있다.

Abstract translation: 公开了使用在包括N-连接的糖基化基序的蛋白质中的去糖基化肽片段与非糖基化肽片段的比例来筛选癌症诊断标记物的方法; 由此选择的标记; 使用该标记的癌症诊断方法; 以及用于诊断或预后分析的组合物和试剂盒。 本发明的方法能够开发与现有标记相比具有更高精度和特异性的癌相关标志物。 此外，通过本发明开发的生物标志物允许以高精度和灵敏度对癌症的早期诊断，癌症的监测和癌症进展的确定，从而通过使用血液的非侵入性测试简单有效地诊断监测癌症 ，因此可用于确认癌症的治疗或不治疗以及癌症的治疗进展以及癌症的早期检测。

公开(公告)号：KR101520615B1

公开(公告)日：2015-05-18

申请号：KR1020130029626

申请日：2013-03-20

Applicant: 서울대학교산학협력단

Inventor： 김영수 ,  윤정환 ,  김현수 ,  진종화

IPC: C12Q1/68 ,  G01N33/53 ,  G01N33/48

CPC classification number: G01N33/57438 ,  G01N33/5079 ,  G01N2333/9015 ,  G01N2333/90206 ,  G01N2333/96413

Abstract: 본원은 ACADVL, ANLN, BASP1, MTHFD1, CAPN1, C4A, FLNB 및 PABPC1로구성되는군으로부터선택되는하나이상의간암진단또는예후측정용간암바이오마커, 이를포함하는간암진단또는예후측정키트, 조성물및 방법에관한것이다. 본원에따른바이오마커는높은정확도와민감도로간세포암의조기진단, 모니터링및 질병정도를유의적으로예측또는파악할수 있다. 또한혈액또는뇨 등을이용한비침습성검사로간단하고유효성있는간암진단또는모니터링이가능하여, 예를들면 POCT (point of care testing) 개발을통한가정및 일반의원에서의간암조기발견에매우유용할것이다.

公开(公告)号：KR1020140115490A

公开(公告)日：2014-10-01

申请号：KR1020130029626

申请日：2013-03-20

Applicant: 서울대학교산학협력단

Inventor： 김영수 ,  윤정환 ,  김현수 ,  진종화

IPC: C12Q1/68 ,  G01N33/53 ,  G01N33/48

CPC classification number: G01N33/57438 ,  G01N33/5079 ,  G01N2333/9015 ,  G01N2333/90206 ,  G01N2333/96413 ,  C12Q1/6886

Abstract: The present invention relates to at least one biomarker for diagnosing liver cancer or measuring liver cancer prognosis, selected from a cluster composed of ACADVL, ANLN, BASP1, MTHFD1, CAPN1, C4A, FLNB and PABPC1, and to a kit, a composition and a method for measuring liver cancer prognosis or diagnosing liver cancer comprising the same. The biomarker according to the present invention can predict and identify an early diagnosis of hepatoma, monitoring and degree of the disease with high accuracy and sensitivity. Also simple and significant diagnosis of liver cancer or monitoring can be done with a noninvasive test using blood or urine, and the biomarker is useful in early diagnosis of liver cancer at home or an ordinary clinic through, for example, point of care testing (POCT) development.

Abstract translation: 本发明涉及选自由ACADVL，ANLN，BASP1，MTHFD1，CAPN1，C4A，FLNB和PABPC1组成的簇中的至少一种用于诊断肝癌或测定肝癌预后的生物标志物，以及试剂盒，组合物和 用于测量肝癌预后或诊断包括其的肝癌的方法。 根据本发明的生物标志物可以以高精度和灵敏度预测和鉴定肝癌的早期诊断，监测和疾病程度。 还可以通过使用血液或尿液的无创检测来进行肝癌或监测的简单和重要的诊断，并且生物标志物可用于通过例如护理点测试（POCT）在家或普通诊所的早期诊断肝癌 ）发展。

公开(公告)号：KR100778763B1

公开(公告)日：2007-11-27

申请号：KR1020060111404

申请日：2006-11-13

Applicant: 한국과학기술원

Inventor： 양동열 ,  김경진 ,  윤정환

IPC: B21C23/00

Abstract: A drawing type continuous shear deformation equipment with an idle roll is provided to mass produce a workpiece with improved mechanical properties continuously by continuously performing a conventional ECAP(Equal Channel Angular Pressing) process and continuously supplying a metal workpiece to a shear deformation mold, thereby shear deforming the workpiece without limiting the length of the workpiece. A drawing type continuous shear deformation equipment(100) with an idle roll comprises: first upper and lower molds(120,130) for forming an inflow part into which a workpiece(170) flows; second upper and lower molds(140,150) which shear deforms the workpiece and forms a discharge part for discharging the shear deformed workpiece; an idle roll(110) disposed between the first upper and lower molds and the second upper and lower molds to form a shear deforming part in an outlet of the first upper and lower molds and an inlet of the second upper and lower molds respectively; and a drawing device for drawing out and transferring the workpiece.

Abstract translation: 提供了一种具有空转辊的拉伸型连续剪切变形设备，通过连续执行常规的ECAP（等通道角度压制）工艺并连续地将金属工件供应到剪切变形模具，从而大量生产具有改善的机械性能的工件，从而剪切 使工件变形而不限制工件的长度。 具有空转辊的拉伸式连续剪切变形设备（100）包括：用于形成工件（170）流入的流入部分的第一上模具和下模具（120,130） 第二上下模具（140,150），其剪切工件变形并形成用于排出剪切变形工件的排出部分; 设置在所述第一上模具和下模具之间的空转辊（110）和所述第二上下模具，以分别在所述第一上下模具的出口和所述第二上模具和下模具的入口中形成剪切变形部件; 以及用于拉出和传送工件的拉丝装置。