신경안정 및 항불안 효능을 갖는 산국화 추출물 및 이를함유하는 조성물
    21.
    发明授权
    신경안정 및 항불안 효능을 갖는 산국화 추출물 및 이를함유하는 조성물 失效
    含有抗坏血酸活性的蛋氨酸指示物的分类和包含其的组合物

    公开(公告)号:KR100806035B1

    公开(公告)日:2008-02-26

    申请号:KR1020060113793

    申请日:2006-11-17

    Inventor: 장춘곤 김선여

    Abstract: An extract of Crysanthemum indicum PRESL or a fraction thereof is provided to promote the nervous sedation caused by abnormality of various cranial nervous system, thereby being used as a medicine and a health functional food with prophylactic and therapeutic effect on anxiety. A pharmaceutical composition for preventing and treating anxiety comprises an extract of Crysanthemum indicum PRESL having anti-anxiety activity and prepared by using a solvent such as water, C1-4 lower alcohol and a mixture solvent thereof or a fraction thereof as an effective ingredient, a pharmaceutically acceptable carrier, a diluent or an excipient, where the fraction is obtained by subjecting the extract of a Dianion chromatography method using a developing solvent such as water, methanol and a mixture solvent thereof. A health functional food for preventing anxiety comprises the extract of Crysanthemum indicum PRESL or the fraction thereof, and a sitologically acceptable food supplement additive.

    Abstract translation: 提供菊花PRESL或其一部分的提取物以促进由各种颅神经系统的异常引起的神经镇静,从而用作药物和对焦虑具有预防和治疗作用的健康功能食品。 用于预防和治疗焦虑症的药物组合物包含具有抗焦虑活性的菊酯提取物,并通过使用溶剂如水,C 1-4低级醇及其混合溶剂或其一部分作为有效成分制备, 药学上可接受的载体,稀释剂或赋形剂,其中通过使用显影溶剂如水,甲醇及其混合溶剂对Dianion色谱法提取物进行分级。 用于预防焦虑症的健康功能性食品包括菊花提取物或其部分的提取物,以及可食用的食品添加剂。

    소량의 항불안제 약물로 사용가능한 산국화 추출물의 제조 방법
    25.
    发明授权
    소량의 항불안제 약물로 사용가능한 산국화 추출물의 제조 방법 有权
    一种制备能够用作少量抗焦虑药的菊花提取物的方法

    公开(公告)号:KR101702164B1

    公开(公告)日:2017-02-06

    申请号:KR1020130064276

    申请日:2013-06-04

    Inventor: 장춘곤

    CPC classification number: A61K36/284 A61K2236/39

    Abstract: 본발명은, 15 mg/체중kg(추출물중 고형분기준)이하로경구투여시항불안활성을발휘할수 있는산국화추출물의제조방법을제공한다. 상기제조방법의일 양태는분자량 1500 이상으로적어도일부에소수성기를갖는고분자를흡착할수 있는세공을구비한다공성흡착제에산국화수추출물을흡착시키는단계; 및용리액으로물을사용하여유출액을회수하는단계를포함한다. 상기제조방법의다른일 양태는산국화수추출물에에틸아세테이트(EtOAc) 첨가하여용매분획을수행하는단계; 및상기용매분획중 수층을회수하는단계를포함한다.

    Abstract translation: 本发明提供了一种制备菊花提取物的方法,其可以以不超过15mg /重量kg的剂量(基于提取物中的固体)口服施用时可以表现出焦虑缓解活性。 制造方法的一个实施方案包括以下步骤:提供菊花含水提取物至具有细孔的多孔吸附剂,其中分子量至少为1500的聚合物至少在其上至少有一部分具有疏水基团; 并通过使用水作为洗脱液收集排出的溶液。 制造方法的另一个实施方案包括以下步骤:通过向菊花提取物中加入乙酸乙酯(EtOAc)进行溶剂分馏; 并在溶剂分馏过程中收集水层。

    로가닌 또는 그의 염을 포함하는 학습 또는 기억력 증진용조성물
    30.
    发明授权
    로가닌 또는 그의 염을 포함하는 학습 또는 기억력 증진용조성물 失效
    用于增强包含LOGANIN或其盐的学习或记忆的组合物

    公开(公告)号:KR100838253B1

    公开(公告)日:2008-06-17

    申请号:KR1020070050782

    申请日:2007-05-25

    Inventor: 장춘곤

    Abstract: A pharmaceutical composition or a food composition comprising loganin(7-hydroxy-6-desoxyverbenalin) or a salt thereof is provided to prevent or treat learning disorder or memory and enhance learning or memory. A pharmaceutical composition for preventing and treating difficulty of learning or memory disorder, or enhancing the memory comprises loganin or a salt thereof and a pharmaceutically acceptable carrier. The loganin or the salt thereof is used as a food composition for enhancing the learning or the memory.

    Abstract translation: 提供了包含洛可宁(7-羟基-6-脱氧蝶呤素)或其盐的药物组合物或食品组合物以防止或治疗学习障碍或记忆,并增强学习或记忆。 用于预防和治疗学习或记忆障碍困难或增强记忆的药物组合物包括洛可宁或其盐和药学上可接受的载体。 使用该草甘膦或其盐作为增强学习或记忆的食物组合物。

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