Abstract:
본 발명은 화학식 3 또는 4로 각각 표시되는 허피스바이러스 엑소뉴클리에이즈 활성을 억제하는 옥소나프탈렌계 화합물 또는 그의 약학적으로 허용가능한 염을 유효성분으로 함유하는 항허피스바이러스용 약학적 조성물을 제공한다. 상술한 본 발명에 의하면 허피스바이러스 엑소뉴클리에이즈 활성을 억제하여 감마허피스바이러스 등 허피스바이러스에 의한 질환 내지 질병을 약물독성 또는 약물내성 없이 효율적으로 치료 또는 예방할 수 있는 이점이 있다.
Abstract:
A reporter cell line for searching a gamma herpesvirus reactivation inducing material latent-infected in a gammaherpesvirus is provided to induce activation of a virus which is in a latent period so that a gamma herpesvirus can work. A reporter cell line for searching a gamma herpesvirus reactivation inducing material latent-infected in a gammaherpesvirus comprises a PAN RNA(polyadenylated nuclear RNA) promoter(sequence number 1) of Kaposi's sarcoma-associated herpesvirus(KSHV) and a gene structure with a report gene connected to be operated. The report gene is destabilized enhanced green fluorescent protein(EGFP).
Abstract:
PURPOSE: A pharmaceutical composition containing angelicin or phramaceutically accepable salt thereof is provided to effectively treat or prevent diseases by herpes virus without drug toxicity or drug resistance. CONSTITUTION: A pharmaceutical composition for anti-herpes contains angelicin of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. The angelicin is derived from Psoralea corylifolia. The composition has an antiviral activity to gamma herpes virus including Epstein-Barr virus(EBV) or Kaposi's sarcoma associated virus(KSHV). The concentration of the angelicin is 15-120 ug/ml.
Linne )를 유효성분으로 포함하는 감마허피스바이러스 재활성 유도 약제학적 조성물에 관한 것이다. 상기한 본 발명에 의하면, 잠복기 상태의 감마허피스바이러스의 재활성을 유도하여 기존의 항허피스 제제가 작용하도록 할 수 있을 뿐만 아니라 독성도 없는 천연물질인 파두를 이용하므로, KSHV 및 EBV와 같은 감마허피스바이러스 감염 종양 세포에서의 암용해성 바이러스 치료에 매우 유용하게 이용될 수 있다. 감마허피스바이러스, KSHV, 재활성, RTA, 파두
Abstract:
A pharmaceutical composition containing Tiglii semen is provided to induce reactivation of the gamma herpesvirus in a latency state, thereby treating cancer-soluble virus in gamma herpesvirus infection tumor cells such as KSHV(Kaposi's sarcomaassociated herpesvirus) and EBV(Epstein-Barr virus). A pharmaceutical composition comprises Tiglii semen and a pharmaceutically allowable carrier or diluent. The pharmaceutical composition containing Tiglii semen is administered to patients by local, oral administration, injection or slow-release formulation. The pharmaceutical composition containing Tiglii semen plays a role in reactivating gamma herpesvirus. The gamma herpesvirus represents KSHV(Kaposi's sarcomaassociated herpesvirus) and EBV(Epstein-Barr virus).