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公开(公告)号：KR101126618B1
公开(公告)日：2012-03-26
申请号：KR1020090105129
申请日：2009-11-02
Applicant: 사회복지법인 삼성생명공익재단 , 일양약품주식회사 , 숙명여자대학교산학협력단
IPC: A61K31/59 , A61K31/592 , A61K31/593 , A61K35/28
Abstract: 본 발명은 발모 촉진용 조성물에 관한 것으로, 보다 상세하게는 비타민 D로 활성화된 지방 줄기세포를 포함하는 발모 촉진용 조성물, 상기 지방 줄기세포를 포함하는 탈모 또는 무모증의 예방 및 치료용 조성물 및 지방 줄기세포의 발모능 증진 방법에 관한 것이다. 본 발명에서 지방 줄기세포는 비타민 D에 의해서 발모능이 향상되어 더 우수한 발모 효과를 나타내게 된다. 따라서 본 발명의 조성물 및 발모능 증진방법은 발모가 필요한 경우나 탈모/무모증의 예방 및 치료를 위하여 유용하게 사용될 수 있다.
지방 줄기세포, 발모, 탈모, 무모증-
公开(公告)号：KR1020110048363A
公开(公告)日：2011-05-11
申请号：KR1020090105129
申请日：2009-11-02
Applicant: 사회복지법인 삼성생명공익재단 , 일양약품주식회사 , 숙명여자대학교산학협력단
IPC: A61K31/59 , A61K31/592 , A61K31/593 , A61K35/28
CPC classification number: A61K31/59 , A61K31/592 , A61K31/593 , A61K35/28
Abstract: PURPOSE: A composition containing adipose stem cells which are activated by vitamin D is provided to improve hair growth ability and to prevent or treat alopecia. CONSTITUTION: A composition for enhancing hair growth ability of adipose stem cells contains vitamin D as an active ingredient. The adipose stem cells are autologous adipose stem cells. A method for enhancing hair growth ability of adipose stem cells comprises: a step of inoculating adipose stem cells to a medium containing vitamin D for 3-36 hours. The concentration of vitamin D is 10^-8 to 10^-4 M.
Abstract translation: 目的：提供含有由维生素D活化的脂肪干细胞的组合物，以改善毛发生长能力并预防或治疗脱发。 构成：用于增强脂肪干细胞的毛发生长能力的组合物含有维生素D作为活性成分。 脂肪干细胞是自体脂肪干细胞。 一种增强脂肪干细胞毛发生长能力的方法包括：将脂肪干细胞接种到含有维生素D的培养基中3-36小时的步骤。 维生素D的浓度为10 ^ -8至10 ^ -4 M.
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公开(公告)号：KR1020090009539A
公开(公告)日：2009-01-23
申请号：KR1020070072918
申请日：2007-07-20
Applicant: 숙명여자대학교산학협력단 , 사회복지법인 삼성생명공익재단
CPC classification number: Y02A50/469 , A61K38/4893 , A61K35/35
Abstract: A pharmaceutical composition comprising Botulinum toxin as the active ingredient is provided to improve safety of use by inhibiting immune rejection response, and increase the engraft rate by extending the blood vessel in the graft site of adipocyte and increasing the remaining amount of adipocyte, thereby promoting the adipocyte engraft. The pharmaceutical composition for promoting the adipocyte engraft comprises adipocyte and Botulinum toxin such as Botulinum A-type toxin which is secreted from Clostridium botulinum and blocks the neuro-transmission in the synapse having acetylcolin receptor by blocking release of acetylcholine from the nerve end.
Abstract translation: 提供包含肉毒杆菌毒素作为活性成分的药物组合物，以通过抑制免疫排斥反应来提高使用的安全性，并且通过延长脂肪细胞的移植部位中的血管并增加脂肪细胞的剩余量来增加移植物速率，从而促进 脂肪细胞移植 用于促进脂肪细胞移植物的药物组合物包括脂肪细胞和肉毒杆菌毒素，例如肉毒杆菌A型毒素，其由肉毒杆菌分泌，并通过阻断乙酰胆碱从神经末梢释放而阻断具有乙酰胆碱受体的突触中的神经传递。
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公开(公告)号：KR1020170110745A
公开(公告)日：2017-10-12
申请号：KR1020160034323
申请日：2016-03-23
Applicant: 숙명여자대학교산학협력단
Inventor： 조대호
Abstract: 본발명은피부재생또는상처치료를위한적혈구분화조절인자 1 (Erythroid differentiation regulator 1)의신규한용도에관한것이다. 본발명에서, 상기폴리펩타이드를처리함으로써, 상피세포또는섬유아세포의이동능및 콜라겐생성량이현저하게증가하였을뿐만아니라, 급성창상동물모델에서의우수한상처치유효과를확인할수 있었는바, 기존의피부재생또는상처치료용제제를대체할수 있는유효물질로활용될수 있을것으로기대된다.
Abstract translation: 本发明涉及红细胞分化调节剂1用于皮肤再生或伤口愈合的新用途。 在本发明中，通过处理肽，上皮细胞或成纤维细胞运动性能和胶原蛋白的产生以及所述hayeoteul显著增加了聚酯，在动物模型中急性伤口eseoui iteotneun可以使优异的创伤愈合效果棒，老皮肤再生或 预计它可以用作替代伤口处理溶剂的有效物质。
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Patent Agency Ranking
公开(公告)号：KR1020140005110A
公开(公告)日：2014-01-14
申请号：KR1020130077792
申请日：2013-07-03
Applicant: 일양약품주식회사 , 숙명여자대학교산학협력단 , 사회복지법인 삼성생명공익재단
CPC classification number: C07K7/08 , A23L33/18 , A23V2002/00 , A61K38/00 , C07K5/06086 , C07K5/06095 , C07K5/06113 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/0817 , C07K5/1019 , C07K7/06
Abstract: The present invention relates to novel peptides and uses thereof, and more particularly, to a peptide having an anti-inflammatory effect, a polynucleotide coding the peptide, a pharmaceutical composition for prevention or treatment of inflammatory diseases containing the peptide or the polynucleotide, an anti-inflammatory agent, a quasi-drug composition for prevention or improvement of inflammation containing the peptide, a health functional food composition for alleviation or improvement of inflammation, a cosmetic composition for prevention or improvement of inflammation, a method for treating inflammatory diseases, comprising a step of administering the pharmaceutical composition to a suspected object with inflammatory disease, a method for preparing a mimetic of the peptide, and a method for designing the mimetic of the peptide.
Abstract translation: 本发明涉及新型肽及其用途，更具体地涉及具有抗炎作用的肽，编码该肽的多核苷酸，用于预防或治疗含有肽或多核苷酸的炎性疾病的药物组合物，抗 - 炎症剂，用于预防或改善含有该肽的炎症的准药物组合物，用于缓解或改善炎症的健康功能性食品组合物，用于预防或改善炎症的化妆品组合物，治疗炎性疾病的方法，包括： 将药物组合物施用于具有炎性疾病的疑似物体的步骤，制备肽模拟物的方法以及设计肽模拟物的方法。
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公开(公告)号：KR1020120130459A
公开(公告)日：2012-12-03
申请号：KR1020110048396
申请日：2011-05-23
Applicant: 일양약품주식회사 , 숙명여자대학교산학협력단 , 사회복지법인 삼성생명공익재단
IPC: A61K31/4439 , A61P35/00
CPC classification number: A61K31/4439
Abstract: PURPOSE: A composition containing ilaprazole or pharmaceutically acceptable salts thereof is provided to effectively suppress cancer cells. CONSTITUTION: A composition for preventing and treating cancer contains ilaprazole of chemical formula 1 or pharmaceutically acceptable salts thereof as an active ingredient. The ilaprazole of chemical formula 1 is 2-[[(4-methoxy-3-methyl)-2-pyridinyl]methyl sulfinyl]-5-(1H-pyrrole-1-yl)-1H-benzimidazole. The composition additionally contains pharmaceutically acceptable carriers. The pharmaceutical composition is manufactured in the form of powder, granules, tablets, pills, capsules, liquids, gels, syrups, suspensions, and wafers.
Abstract translation: 目的：提供含有伊拉唑或其药学上可接受的盐的组合物以有效抑制癌细胞。 构成：用于预防和治疗癌症的组合物含有化学式1的伊拉唑或其药学上可接受的盐作为活性成分。 化学式1的吡拉唑是2 - [[（4-甲氧基-3-甲基）-2-吡啶基]甲基亚磺酰基] -5-（1H-吡咯-1-基）-1H-苯并咪唑。 该组合物另外含有药学上可接受的载体。 药物组合物以粉末，颗粒，片剂，丸剂，胶囊，液体，凝胶，糖浆，悬浮液和晶片的形式制造。
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公开(公告)号：KR101019877B1
公开(公告)日：2011-03-04
申请号：KR1020080098149
申请日：2008-10-07
Applicant: 숙명여자대학교산학협력단 , 사회복지법인 삼성생명공익재단
CPC classification number: C12N5/0653 , C12N2500/25 , C12N2501/39 , C12N2501/82
Abstract: 본 발명은 지방세포 분화용 배지 조성물에 있어서, 인슐린(insulin), DHEA(dehydroepiandrosterone) 및 히스타민(histamine)을 함유하는 것을 특징으로 하는 지방세포 분화용 배지 조성물 및 상기 배지 조성물을 이용하여 지방전구세포(preadipocyte)를 지방세포(adipocyte)로 분화시키는 방법에 관한 것이다. 본 발명의 지방세포 분화용 배지 조성물은 통상적으로 사용되는 지방세포 분화용 배지 조성물에 비해 분화된 지방세포의 분포가 고르고 분화된 지방세포가 안정적으로 고정될 수 있도록 하여 생존율을 극대화할 수 있는 장점이 있다. 또한 본 발명의 지방세포 분화용 배지 조성물에 사용되는 DHEA(dehydroepiandrosterone) 및 히스타민(histamine)은 종래 사용되던 덱사메타손(dexamethasone) 및 아이소부틸메틸젠틴(isobutylmethylxanthine)에 비하여 가격이 저렴하므로 경제적인 장점이 있다.
지방세포, 분화, 배지, 조성물-
公开(公告)号：KR1020090022671A
公开(公告)日：2009-03-04
申请号：KR1020070088219
申请日：2007-08-31
Applicant: 숙명여자대학교산학협력단 , 사회복지법인 삼성생명공익재단
Abstract: Provided is a composition with preadipocyte for promoting hair growth and enabling a user to easily use the composition at a desired area. A composition for hair growth comprises preadipocyte as an active ingredient. The preadipocyte is autologous preadipocyte obtained by liposuction. The composition for hair growth independently contain the preadipocyte or additionally includes one or more pharmaceutically allowed carrier, excipient, or diluent. The composition for hair growth is percutaneously injected under the skin.
Abstract translation: 提供了一种具有用于促进头发生长的前脂肪细胞的组合物，并且使得使用者能够在期望的区域容易地使用该组合物。 用于毛发生长的组合物包含前脂肪细胞作为活性成分。 前脂肪细胞是通过吸脂获得的自体前脂肪细胞。 用于毛发生长的组合物独立地含有前脂肪细胞，或另外包括一种或多种药学上允许的载体，赋形剂或稀释剂。 用于毛发生长的组合物经皮注射到皮肤下。
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公开(公告)号：KR1020090009540A
公开(公告)日：2009-01-23
申请号：KR1020070072919
申请日：2007-07-20
Applicant: 숙명여자대학교산학협력단 , 사회복지법인 삼성생명공익재단
CPC classification number: A61K38/2292 , C07K14/57581 , Y10S514/885
Abstract: A composition comprising thymosin beta 4 is provided to increase immunity by inducing the proliferation and activation of the natural killer cell, so that the composition is useful as non-specific immunity reinforcing agent. The composition for reinforcing the immunity comprises thymosin beta 4 capable of inducing the proliferation of the natural killer cell as an effective ingredient, and further comprises carrier, excipient and diluent such as lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, maltitol, starch, glycerin, starch, gum acacia, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methylcellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propyl hydroxy benzoate, talc, magnesium stearate and mineral oil. The non-specific immunity reinforcing agent comprises the immunity reinforcing composition comprising thymosin beta 4.
Abstract translation: 提供包含胸腺素β4的组合物以通过诱导天然杀伤细胞的增殖和活化来提高免疫力，使得该组合物可用作非特异性免疫增强剂。 用于增强免疫力的组合物包括能够诱导天然杀伤细胞增殖作为有效成分的胸腺素β4，并且还包含载体，赋形剂和稀释剂如乳糖，葡萄糖，蔗糖，山梨糖醇，甘露糖醇，木糖醇，麦芽糖醇，淀粉 ，甘油，淀粉，阿拉伯树胶，藻酸盐，明胶，磷酸钙，硅酸钙，纤维素，甲基纤维素，微晶纤维素，聚乙烯吡咯烷酮，水，甲基羟基苯甲酸甲酯，羟基苯甲酸丙酯，滑石，硬脂酸镁和矿物油。 非特异性免疫增强剂包含包含胸腺素β4的免疫增强组合物。
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