公开(公告)号：KR1020120078098A

公开(公告)日：2012-07-10

申请号：KR1020100140283

申请日：2010-12-31

Applicant: 숭실대학교산학협력단

Inventor： 주상우 ,  정새로미 ,  박진호 ,  조근창 ,  이소영

IPC: G01N33/15 ,  G01N21/65 ,  A61K47/48 ,  A61K31/7088

CPC classification number: G01N33/15 ,  A61K31/7088 ,  A61K47/50 ,  G01N21/658

Abstract: PURPOSE: A method for measuring RNA interference delivery efficiency and position using RNAi, and chitosan, or BPEI metal nanoparticle complex is provided to treat lung cancer. CONSTITUTION: A method for measuring delivery efficiency of delivery drug-captured metal nano complex comprises: a step of contacting the metal nanoparticle complex to cells; a step of measuring the cell by z-depth dependent confocal SERS(surface enhanced raman scattering) after predetermined time; and a step of comparing the absorption of the intracellular metal nanoparticles with a control group to measure delivery efficiency.

Abstract translation: 目的：提供用RNAi和壳聚糖或BPEI金属纳米粒子复合物测定RNA干扰递送效率和位置的方法来治疗肺癌。 构成：用于测量递送药物捕获的金属纳米复合物的递送效率的方法包括：使金属纳米颗粒复合体与细胞接触的步骤; 在预定时间后通过z深度依赖共焦SERS（表面增强拉曼散射）测量细胞的步骤; 以及将细胞内金属纳米粒子的吸收与对照组进行比较以测量递送效率的步骤。