公开(公告)号：KR1020150104309A

公开(公告)日：2015-09-15

申请号：KR1020140025874

申请日：2014-03-05

Applicant: 재단법인대구경북과학기술원

Inventor： 문상준 ,  문현민

IPC: G01N30/58 ,  G01N33/574 ,  G01N33/483 ,  G01N15/10

CPC classification number: G01N30/58 ,  G01N15/10 ,  G01N15/1031 ,  G01N27/00 ,  G01N27/3275 ,  G01N33/483 ,  G01N33/574 ,  G01N35/08 ,  G01N2030/582

Abstract: 본 발명은 동전기적 농축장치를 이용한 타켓 세포 검출방법에 관한 것으로, 구체적으로 양전하로 대전된 나노비드에 표적 세포에 특이적인 항체를 결합시켜 항체-나노비드 복합체를 제조하는 단계, 상기 항체-나노비드 복합체를 시료와 접촉시켜 시료 내 항원을 결합시키는 단계, 상기 항원-항체-나노비드 복합체를:
a) 적어도 하나 이상의 마이크로채널;
b) 상기 마이크로채널과 연결되는 적어도 하나 이상의 양전하 도핑된 나노채널;
c) 상기 마이크로채널 및 상기 나노채널 내에서 전장을 유도하기 위한 전극; 및
d) 양전하 대전된 나노비드와 항체가 결합된 항체-나노비드가 항원과 결합하여 항원-항체-나노비드가 저장되며, 상기 마이크로채널과 연결되는 저장소로 구성된 것을 특징으로 하는 단계;
로 구성된 동전기적 농축 장치의 마이크로채널에 유입시키는 단계, 상기 동전기적 농축장치에 외부 전압을 걸어주어 상기 유입된 용액에 포함된 항원-항체-나노비드 복합체를 농축시키는 단계 및 상기 농축된 항원-항체-나노비드 복합체를 검출하는 단계를 포함하는 표적 세포의 검출방법은 신속하고 효율적인 표적 세포의 분류 및 의학적 진단에 유용하게 이용될 수 있다.

Abstract translation: 本发明涉及使用电动动力学浓度系统检测靶细胞的方法。 更具体地，使用电动力学浓度系统检测靶细胞的方法包括：通过将特异性抗体与靶细胞偶联和用正电荷带电的纳米棒制备抗体 - 纳米针复合物的步骤; 通过使抗体 - 纳米复合材料和样品彼此接触来将样品中的抗体偶联的步骤; 将抗原 - 抗体 - 纳米针复合物引入电动力学浓度系统的微通道的步骤，其中所述电动力学浓度系统包括：a）至少一个微通道; b）掺杂有至少一个与微通道连接的正电荷的纳米通道; c）用于从电通道和纳米通道感应电场的电极; 和d）通过将其中与正电荷和抗体电连接的纳米银偶联的抗体 - 纳米针与抗原偶联并与微通道连接而存储抗原 - 抗体 - 纳米针的储存器; 通过向电动浓度系统施加外部电压来浓缩包含在溶液中的抗原 - 抗体 - 纳米针复合物的步骤; 以及检测浓缩的抗原 - 抗体 - 纳米针复合物的步骤。 使用电动力学浓度系统检测靶细胞的方法可有效地用于目标细胞的快速有效分类和医学诊断。

公开(公告)号：KR1020140109629A

公开(公告)日：2014-09-16

申请号：KR1020130023815

申请日：2013-03-06

Applicant: 재단법인대구경북과학기술원

Inventor： 정혁 ,  유현수 ,  강유나 ,  문상준

IPC: C12M1/00 ,  C12M3/00 ,  C12Q1/02

CPC classification number: C12M23/04 ,  C12M41/08 ,  C12Q1/02

Abstract: The present invention relates to an apparatus for inducing the migration of neurons using phototaxis. According to the present invention, the apparatus for inducing the migration of neurons comprises: a culture plate in which neurons are put in random spots; a light source part emitting a light source into the culture plate, but emitting the light source of an optional wavelength into spots adjacent to the neurons; an imaging module observing movements for migration or growth of the neurons by the light source; and an analyzing part analyzing an effect of the light source of the optional wavelength on the migration of the neurons using the observed images. According to the apparatus for inducing the migration of neurons using phototaxis, neurons can be induced to directly move to the spot where the light source is emitted and grow, thereby facilitating the regeneration of defect or damaged neurons. Also, neurons can be induced to grow by being connected in a form corresponding to a pattern using a specific pattern formed when the light source passes.

Abstract translation: 本发明涉及一种使用光感引起神经元迁移的装置。 根据本发明，用于诱导神经元迁移的装置包括：将神经元置于随机斑点的培养板; 将光源发射到培养板中，但将可选波长的光源发射到与神经元相邻的点中的光源部分; 成像模块观察由光源迁移或生长神经元的运动; 以及分析部分，分析可选波长的光源对使用观察图像的神经元迁移的影响。 根据使用光趋向性诱导神经元迁移的装置，可以诱导神经元直接移动到光源发射和生长的位置，从而促进缺陷或损伤的神经元的再生。 此外，可以通过以与光源通过时形成的特定图案相对应的图案的形式来连接神经元来生长。

公开(公告)号：KR101415047B1

公开(公告)日：2014-07-04

申请号：KR1020120157541

申请日：2012-12-28

Applicant: 재단법인대구경북과학기술원

Inventor： 문상준 ,  정혁 ,  이경제

IPC: A61B5/11 ,  A61B5/00 ,  G01L5/00

Abstract: The present invention relates to a plantar pressure measurement device. More particularly, the plantar pressure measurement device includes a base having a receiving space, a pressure sensing plate which is formed in the base and has an upper surface which is exposed to the outside and is made of an elastic material, pressure sensing parts which are arranged in corresponding parts for measuring a pressure in the pressure sensing plate, and a control module which detects an electrical resistance value outputted from the pressure sensing parts and calculates and outputs it. The present invention provides a plantar pressure measurement device which is light and is suitable for measuring the plantar pressure of a body having a curved surface, solves repulsion due to existing hardness and coolness, reacts with a minute pressure, accurately measures a pressure compared to an existing invention.

Abstract translation: 本发明涉及一种足底压力测量装置。 更具体地，足底压力测量装置包括具有容纳空间的底座，形成在基部中的具有暴露于外部并由弹性材料制成的上表面的压力感测板，压力感测部分 布置在用于测量压力感测板中的压力的​​相应部分中;以及控制模块，其检测从压力感测部件输出的电阻值并计算并输出。 本发明提供了一种轻便且适于测量具有弯曲表面的身体的足底压力的足底压力测量装置，解决了由于现有的硬度和冷却而引起的排斥，与微小的压力反应，精确地测量与 现有发明。

公开(公告)号：KR101399511B1

公开(公告)日：2014-05-27

申请号：KR1020120157538

申请日：2012-12-28

Applicant: 재단법인대구경북과학기술원

Inventor： 문현민 ,  강유나 ,  임희진 ,  문상준

IPC: G01N35/08 ,  B81B3/00 ,  G01N37/00

Abstract: The present invention relates to a device for controlling fluid using a microfluidic chip. The device for controlling fluid using a microfluidic chip according to one embodiment of the present invention includes a channel layer which has a plurality of microfluidic channels through which fluid passes, a fluid film which is formed on the lower part of the channel layer and opens or blocks the microfluidic channels, and a microfluidic chip which is formed at the lower part of the fluid film and has an air hole layer with a plurality of air holes through which external air is injected. Therefore, the device can control the flow of microfluid by opening or closing the channels by injecting air into the fluid film in contact with the channels in a predetermined pattern to precisely control the microfluidic channels of the microfluidic chip.

Abstract translation: 本发明涉及使用微流控芯片来控制流体的装置。 根据本发明的一个实施例的用于使用微流控芯片控制流体的装置包括通道层，其具有多个流体通过的微流体通道，流体膜形成在通道层的下部并打开或 阻止微流体通道，以及形成在流体膜的下部的微流体芯片，并且具有带有多个空气孔的空气孔层，外部空气通过该空气孔注入。 因此，该装置可以通过以预定图案将空气注入与通道接触的流体膜中来打开或关闭通道来控制微流体的流动，以精确地控制微流体芯片的微流体通道。