公开(公告)号：KR100986604B1

公开(公告)日：2010-10-08

申请号：KR1020100029848

申请日：2010-04-01

Applicant: 충남대학교산학협력단

Inventor： 박정숙 ,  김현기 ,  명창선

IPC: C12N15/88 ,  C12N15/113 ,  C12N15/115 ,  A61K9/127

Abstract: PURPOSE: A composition for transferring nucleic acid using aminolipid having distearoyl phosphatidylethanolamine-polyethylene glycol and poly-L-arginine is provided to improve efficiency of transferring nucleic acid into cells. CONSTITUTION: An oligonucleic acid carrier contains: an aminolipid formed by chemical conjugation of distearoylphosphatidylethanolamine-polyethyleneglycol to DEPE-PEG; a cationic lipid. The oligonucleic acid carrier is used for transferring siRNA, antisense or aptamer to the cells. The oligonucleic acid carrier is liposome. The liposome is 1,2-dioleoyl-3-trimethylammoniu-propane(DOTAP), 1,2-diacyl-sn-glycero-3-phosphoethanolamine(DOPE), and cholesterol.

Abstract translation: 目的：提供使用具有二硬脂酰磷脂酰乙醇胺 - 聚乙二醇和聚-L-精氨酸的氨基脂质转运核酸的组合物，以提高将核酸转运到细胞中的效率。 构成：寡核酸载体包含：通过二硬脂基磷脂酰乙醇胺 - 聚乙二醇与DEPE-PEG的化学共轭形成的氨基脂; 阳离子脂质。 寡核酸载体用于将siRNA，反义或适体转移至细胞。 寡核酸载体是脂质体。 脂质体是1,2-二油酰-3-三甲基铵 - 丙烷（DOTAP），1,2-二酰基-sn-甘油-3-磷酸乙醇胺（DOPE）和胆固醇。

公开(公告)号：KR100781571B1

公开(公告)日：2007-12-03

申请号：KR1020070044633

申请日：2007-05-08

Applicant: 충남대학교산학협력단

Inventor： 송규용 ,  신현중 ,  서영배 ,  이지현 ,  명창선 ,  오한진 ,  박용진

IPC: A61K36/258 ,  A61P35/00

Abstract: 본 발명은 인삼을 세척하여 적정 온도 및 시간으로 건조 및 증숙을 반복하는 공정을 통하여 기존의 구증구폭의 방법으로 제조된 흑삼에 비하여 시간이 단축되며, 대량생산이 가능한 항암활성을 갖는 흑삼을 제조하는 방법에 관한 것으로, 이로부터 제조된 흑삼 및 이의 추출물은 뛰어난 항암 효과를 나타내어 암질환의 예방 및 치료를 위한 조성물로 이용될 수 있다.
흑삼, 대량생산, 수삼, 구증구폭, 항암

公开(公告)号：KR1020070111335A

公开(公告)日：2007-11-21

申请号：KR1020070044633

申请日：2007-05-08

Applicant: 충남대학교산학협력단

Inventor： 송규용 ,  신현중 ,  서영배 ,  이지현 ,  명창선 ,  오한진 ,  박용진

IPC: A61K36/258 ,  A61P35/00

Abstract: A pharmaceutical composition comprising the extract of novel black ginseng is provided to reduce the preparation time, allow mass production of black ginseng and improve anticancer effects by increasing or identically maintaining the ginseng saponin content in black ginseng compared to the conventional preparation method(nine steaming nine drying method) of black ginseng. A pharmaceutical composition comprises 0.1-50 wt.% of the extract of novel black ginseng which is prepared by washing 4-6 year old fresh ginsengs and drying them at 35-55 deg.C for 20-28 hours, steaming the dried ginseng at 85-105 deg.C for 5-7 hours in a pot, drying the steamed ginseng at 50-70 deg.C for 9-15 hours, steaming the secondly dried ginseng at 95-125 deg.C for 5-7 hours, drying the secondly steamed ginseng for 12 hours, pulverizing the thirdly dried ginseng and storing the pulverized ginseng in water for 3-7 hours, and extracting the water-dipped pulverized ginseng with water, C1-C4 lower alcohol or a mixed solvent thereof.

Abstract translation: 提供一种包含新型黑参提取物的药物组合物，以减少制备时间，通过增加或相同地维持黑参中人参皂甙含量，与常规制备方法相比，可以批量生产黑参，提高抗癌效果（九蒸九 干燥方法）黑参。 一种药物组合物包含0.1-50重量％的新黑参提取物，其通过洗涤4-6岁的新鲜人参并在35-55℃下干燥20-28小时，将干燥的人参蒸 85-105℃，5-7小时，在50-70℃干燥人参9-15小时，将第二次干燥的人参在95-125℃下蒸5〜7小时， 将第二次人参干燥12小时，粉碎第三次干参，将粉碎的人参储存在水中3-7小时，用水，C1-C4低级醇或其混合溶剂萃取水浸的人参。