公开(公告)号：KR101035463B1

公开(公告)日：2011-05-18

申请号：KR1020070141245

申请日：2007-12-31

Applicant: 충남대학교산학협력단

Inventor： 송규용 ,  서상희 ,  김상겸 ,  박용진

IPC: A61K36/258 ,  A61P31/16

Abstract: 본 발명은 고온고압 제조방법을 이용하여 제조된 흑삼 뿌리로부터 추출된 추출물을 유효성분으로 함유하는 조성물에 관한 것으로, 상세하게는 본 발명의 조성물은 뛰어난 고병원성 조류 인플루엔자 바이러스(highly pathogenic avian influenza)에 대한 억제 효과를 나타내므로, 고병원성 조류 인플루엔자 바이러스 감염증의 예방 및 치료용 약학조성물 및 건강기능식품으로 유용하게 이용될 수 있다.
흑삼, 고병원성 조류 인플루엔자 바이러스

公开(公告)号：KR1020090073328A

公开(公告)日：2009-07-03

申请号：KR1020070141245

申请日：2007-12-31

Applicant: 충남대학교산학협력단

Inventor： 송규용 ,  서상희 ,  김상겸 ,  박용진

IPC: A61K36/258 ,  A61P31/16

Abstract: A composition for preventing and treating highly pathogenic avian influenza virus is provided to have suppression effect to highly pathogenic avian influenza virus by using an extract isolated from Panax ginseng. A method for producing a composition for preventing and treating highly pathogenic avian influenza virus comprises: a step of producing a Panax ginseng; a step of mixing the Panax ginseng with water in a mass ratio of 1:3-7, and maintaining at room temperature for 3-7 hours; a step of adding water containing purified water, low alcohol of C1-4, or their mixture solvent in a mass ratio of 1:5-20; a step of extracting for 2-8 hours one to five times; and a step of cooling, filtering and concentrating the extract.

Abstract translation: 本发明提供了用于预防和治疗高致病性禽流感病毒的组合物，通过使用从人参中分离出的提取物，对高致病性禽流感病毒具有抑制作用。 一种用于预防和治疗高致病性禽流感病毒的组合物的制备方法包括：生产人参的步骤; 将人参与水以1:3-7的质量比混合的步骤，并在室温下保持3-7小时; 以1：5-20的质量比添加含有纯水，C1-4的低级醇或其混合溶剂的水的步骤; 提取2-8小时1-5次; 以及冷却，过滤和浓缩提取物的步骤。

公开(公告)号：KR1020100038258A

公开(公告)日：2010-04-14

申请号：KR1020080097442

申请日：2008-10-04

Applicant: 충남대학교산학협력단

Inventor： 송규용 ,  서상희 ,  김영호 ,  박용진 ,  박천정

IPC: A61K36/258 ,  A61P31/16

Abstract: PURPOSE: A linear double strand RNA molecule reducing expression of different target genes is provided to induce gene silence regardless of inversion orientation of siRNA. CONSTITUTION: A linear double strand RNA molecule contains 2-10 short interference RNAs(siRNA) which are serially connected. The siRNA comprises 18-24 nucleotides. The linear double strand RNA molecule contains two successive siRNAs. Each strand contains two 3'-terminal nucleotides which is not formed in base pair. A recombinant expression vector comprises double strand DNA sequence expressing the linear double strand RNA molecule. The expression of a target gene is suppressed by introducing the recombinant expression vector and linear type double strand RNA molecule in cells.

Abstract translation: 目的：提供减少不同靶基因表达的线性双链RNA分子，以诱导基因沉默，而不管siRNA的倒置方向如何。 构成：线性双链RNA分子含有2-10个短连接RNA（siRNA），它们连接在一起。 siRNA包含18-24个核苷酸。 线性双链RNA分子含有两个连续的siRNA。 每条链含有两个未在碱基对中形成的3'末端核苷酸。 重组表达载体包含表达线性双链RNA分子的双链DNA序列。 通过在细胞中引入重组表达载体和线型双链RNA分子来抑制靶基因的表达。

公开(公告)号：KR100754253B1

公开(公告)日：2007-09-03

申请号：KR1020060044066

申请日：2006-05-17

Applicant: 충남대학교산학협력단

Inventor： 송규용 ,  신현중 ,  서영배 ,  이지현 ,  명창선 ,  오한진 ,  박용진

IPC: A23L1/212

CPC classification number: A61K36/258 ,  A23L33/105 ,  A23V2002/00 ,  A23V2250/2124 ,  A23V2200/308

Abstract: A novel process for manufacturing black ginseng with anti-cancer activity and a composition containing the same are provided to shorten manufacturing time and enable mass production by washing ginseng and repeating drying and steaming at proper temperature and time. A process for manufacturing black ginseng comprises the steps of: washing 5 year old green ginseng and firstly drying the washed ginseng at 35~55°C for 20~28hr; putting the dried ginseng in earthenware and firstly steaming at 85~105°C for 5~7hr; secondly drying the steamed ginseng at 50~70°C for 9~15hr; secondly steaming at 95~125°C for 5~7hr; and thirdly drying for 12hr. The dried black ginseng or extracts are pulverized to a particle of 50~200mum, and then can be prepared into the composition such as a pill, a capsule or a tablet.

Abstract translation: 提供一种制造具有抗癌活性的黑参的新方法和含有该组合物的组合物，以缩短制造时间，并且通过洗涤人参并在适当的温度和时间重复干燥和蒸汽来批量生产。 制造黑参的方法包括：洗涤5岁的青参，首先将洗涤的人参在35〜55℃下干燥20〜28小时; 将干参浸在陶器中，首先在85〜105℃下蒸5〜7小时; 其次在50〜70℃下干燥人参9〜15小时; 其次在95〜125℃下蒸5〜7小时; 第三次干燥12小时。 将干燥的黑参或提取物粉碎成50〜200μm的颗粒，然后可以制备成组合物，例如丸剂，胶囊或片剂。

公开(公告)号：KR100781571B1

公开(公告)日：2007-12-03

申请号：KR1020070044633

申请日：2007-05-08

Applicant: 충남대학교산학협력단

Inventor： 송규용 ,  신현중 ,  서영배 ,  이지현 ,  명창선 ,  오한진 ,  박용진

IPC: A61K36/258 ,  A61P35/00

Abstract: 본 발명은 인삼을 세척하여 적정 온도 및 시간으로 건조 및 증숙을 반복하는 공정을 통하여 기존의 구증구폭의 방법으로 제조된 흑삼에 비하여 시간이 단축되며, 대량생산이 가능한 항암활성을 갖는 흑삼을 제조하는 방법에 관한 것으로, 이로부터 제조된 흑삼 및 이의 추출물은 뛰어난 항암 효과를 나타내어 암질환의 예방 및 치료를 위한 조성물로 이용될 수 있다.
흑삼, 대량생산, 수삼, 구증구폭, 항암

公开(公告)号：KR1020070111335A

公开(公告)日：2007-11-21

申请号：KR1020070044633

申请日：2007-05-08

Applicant: 충남대학교산학협력단

Inventor： 송규용 ,  신현중 ,  서영배 ,  이지현 ,  명창선 ,  오한진 ,  박용진

IPC: A61K36/258 ,  A61P35/00

Abstract: A pharmaceutical composition comprising the extract of novel black ginseng is provided to reduce the preparation time, allow mass production of black ginseng and improve anticancer effects by increasing or identically maintaining the ginseng saponin content in black ginseng compared to the conventional preparation method(nine steaming nine drying method) of black ginseng. A pharmaceutical composition comprises 0.1-50 wt.% of the extract of novel black ginseng which is prepared by washing 4-6 year old fresh ginsengs and drying them at 35-55 deg.C for 20-28 hours, steaming the dried ginseng at 85-105 deg.C for 5-7 hours in a pot, drying the steamed ginseng at 50-70 deg.C for 9-15 hours, steaming the secondly dried ginseng at 95-125 deg.C for 5-7 hours, drying the secondly steamed ginseng for 12 hours, pulverizing the thirdly dried ginseng and storing the pulverized ginseng in water for 3-7 hours, and extracting the water-dipped pulverized ginseng with water, C1-C4 lower alcohol or a mixed solvent thereof.

Abstract translation: 提供一种包含新型黑参提取物的药物组合物，以减少制备时间，通过增加或相同地维持黑参中人参皂甙含量，与常规制备方法相比，可以批量生产黑参，提高抗癌效果（九蒸九 干燥方法）黑参。 一种药物组合物包含0.1-50重量％的新黑参提取物，其通过洗涤4-6岁的新鲜人参并在35-55℃下干燥20-28小时，将干燥的人参蒸 85-105℃，5-7小时，在50-70℃干燥人参9-15小时，将第二次干燥的人参在95-125℃下蒸5〜7小时， 将第二次人参干燥12小时，粉碎第三次干参，将粉碎的人参储存在水中3-7小时，用水，C1-C4低级醇或其混合溶剂萃取水浸的人参。