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Patent Agency Ranking
公开(公告)号：KR101484441B1
公开(公告)日：2015-01-21
申请号：KR1020140008387
申请日：2014-01-23
Applicant: 충남대학교산학협력단
CPC classification number: A61K48/005 , A61K47/542 , A61K47/60 , A61K47/61 , A61K47/6927 , A61K48/0058 , B82Y5/00
Abstract: The present invention relates to a non-viral gene delivery system and uses thereof and, more specifically, to a non-viral gene delivery system using a cationic polymer glycol chitosan-methyl acrylate-polyethyleneimine (GMP) based on polyethylenimine (PEI) which has high transfection efficiency and low cytotoxicity. According to the present invention, a polymer for transporting non-viral hexane and a complex based on the same including nanoparticles having a GMP structure, can provide significantly low cytotoxicity and high transfection efficiency and is effective in gene delivery in cells as used as an effective hexane delivery system, thereby being very useful for medical industries.
Abstract translation: 本发明涉及非病毒基因递送系统及其用途，更具体地，涉及使用基于聚乙烯亚胺（PEI）的聚乙烯亚胺（PEI）的阳离子聚合物二醇壳聚糖 - 甲基丙烯酸甲酯 - 聚乙烯亚胺（GMP）的非病毒基因递送系统， 转染效率高，细胞毒性低。 根据本发明，用于转运非病毒己烷的聚合物和包含具有GMP结构的纳米颗粒的复合物可以提供显着低的细胞毒性和高转染效率，并且在用作有效的细胞中的基因递送中是有效的 己烷输送系统，因此对医疗行业非常有用。
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公开(公告)号：KR101484373B1
公开(公告)日：2015-01-21
申请号：KR1020120136067
申请日：2012-11-28
Applicant: 충남대학교산학협력단
Abstract: 본 발명은 비바이러스성 유전자 전달체 및 이의 용도에 대한 발명으로서, 보다 구체적으로 본 발명은 트랜스펙션 효율이 높고 세포독성이 낮은 폴리에틸렌이민(PEI) 기반의 양이온 중합체 PMP(polyethylenimine-methyl acrylate-polyethylenimine)를 이용하는, 비바이러스성 유전자 전달 시스템에 대한 발명이다.
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公开(公告)号：KR1020140073617A
公开(公告)日：2014-06-17
申请号：KR1020120136067
申请日：2012-11-28
Applicant: 충남대학교산학협력단
Abstract: The present invention relates to a non-viral gene delivery vector and uses thereof and, more specifically, to a non-viral gene delivery vector which uses polyethylenimine (PEI) based cationic polymer polyethylenimine-methyl acrylate-polyethylenimine (PMP) with enhanced transfection efficiency and low cytotoxicity.
Abstract translation: 本发明涉及非病毒基因递送载体及其用途，更具体地涉及使用聚乙烯亚胺（PEI）的阳离子聚合物聚乙烯亚胺 - 丙烯酸甲酯 - 聚乙烯亚胺（PMP）的非病毒基因递送载体，其具有增强的转染效率 和低细胞毒性。
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公开(公告)号：KR1020130024326A
公开(公告)日：2013-03-08
申请号：KR1020110087711
申请日：2011-08-31
Applicant: 충남대학교산학협력단
Abstract: PURPOSE: A PAMAM(polyamidoamine) derivative for nucleic acid delivery is provided to improve a buffering capacity and transfection efficiency without cytotoxicity. CONSTITUTION: A PAMAM derivative for nucleic acid delivery contains PAMAM, histidine, and a cationic compound. The cationic compound is lysine, arginine, or guanidine. The surface of PAMAM is grafted with the cationic compound which is conjugated with a histidine residue. PAMAM is a dendrite type dendrimer.
Abstract translation: 目的：提供用于核酸递送的PAMAM（聚酰胺胺）衍生物，以提高缓冲能力和转染效率而不产生细胞毒性。 构成：用于核酸递送的PAMAM衍生物含有PAMAM，组氨酸和阳离子化合物。 阳离子化合物是赖氨酸，精氨酸或胍。 PAMAM的表面用与组氨酸残基共轭的阳离子化合物接枝。 PAMAM是树枝状树枝状聚合物。
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25.发明公开
公开(公告)号：KR1020100052008A
公开(公告)日：2010-05-19
申请号：KR1020080110851
申请日：2008-11-10
Applicant: 한양대학교 산학협력단 , 충남대학교산학협력단
CPC classification number: A61K47/50 , A61K48/00 , Y10S514/886
Abstract: PURPOSE: A vector containing anionic polymer for treating non-viral inflammatory diseases is provided to improved gene treatment efficiency. CONSTITUTION: An anti-inflammatory vector for treating inflammatory disease contains anti-inflammatory glucocorticoid and anionic polymer. The anionic polymer is polyethyleneimine. The molecular weight of polyethyleneimine is 5kDa. The anti-inflammatory glucocorticoid is hydrocortisone, dexamethesone, betamethasone, prednisone, prednisolone, triamcinolone, beclomethasone, or cortisonacetate. An anti-inflammatory vector for treating flammatory diseases contains the vector and gene.
Abstract translation: 目的：提供含有用于治疗非病毒性炎性疾病的阴离子聚合物的载体，以改善基因治疗效率。 构成：用于治疗炎性疾病的抗炎药物含有抗炎糖皮质激素和阴离子聚合物。 阴离子聚合物是聚乙烯亚胺。 聚乙烯亚胺的分子量为5kDa。 抗炎糖皮质激素是氢化可的松，地塞米松，倍他米松，泼尼松，泼尼松龙，曲安奈德，倍氯米松或醋酸钙。 用于治疗炎性疾病的抗炎药物含有载体和基因。
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