公开(公告)号：KR100393160B1

公开(公告)日：2003-07-31

申请号：KR1020010033382

申请日：2001-06-14

Applicant: 한국과학기술연구원

Inventor： 김중협 ,  김유승 ,  최경일 ,  김동현 ,  남길수 ,  서재홍

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: Novel pyrazolopyrimidinethione compounds of formula 1: wherein R1 and R2 are independently each hydrogen atom, a C1-C6 alkyl group, or a C3-C6 cycloalkyl group, R3 is a C1-C6 alkyl group. C3-C6 cycloalkyl group or C3-C6 alkenyl group which is substituted or unsubstituted, X is O or NR4, and R4 is hydrogen atom, or a C1-C6 alkyl group, a C3-C6 cycloalkyl group or a C3-C6 alkenyl group which is unsubstituted or substituted with OH or an alkoxy group, pharmacologically acceptable salts or hydrates thereof, and preparation methods thereof are disclosed. Pharmaceutical compositions comprising the compounds are effectively used for the treatment of erectile dysfunction.

Abstract translation: 式1的新型吡唑并嘧啶硫酮化合物：其中R 1和R 2各自独立地为氢原子，C 1 -C 6烷基或C 3 -C 6环烷基，R 3为C 1 -C 6烷基。 C 3 -C 6环烷基或被取代或未被取代的C 3 -C 6烯基，X是O或NR 4，并且R 4是氢原子或C 1 -C 6烷基，C 3 -C 6环烷基或C 3 -C 6烯基 其未被取代或被OH或烷氧基取代，其药理学上可接受的盐或水合物及其制备方法。 包含这些化合物的药物组合物有效地用于治疗勃起功能障碍。