-
公开(公告)号：KR1020100059367A
公开(公告)日：2010-06-04
申请号：KR1020080118115
申请日：2008-11-26
Applicant: 한국과학기술연구원
CPC classification number: A61L27/50 , A61L27/18 , A61L27/54 , A61L27/56 , A61L2300/25 , A61L2300/414 , A61L2300/428 , A61L2300/43 , A61L2300/45 , A61L2300/604 , A61L2400/18 , C08L67/04
Abstract: PURPOSE: An intelligent porosity biodegrade polymer support and a manufacturing method thereof are provided, which can induce a musculoskeletal tissue regeneration from stem cell to in situ in a biological tissue. CONSTITUTION: A manufacturing method of an intelligent porosity biodegrade polymer support comprises next steps: a step of obtaining a polymer specimen which contains a bioactive substance in inside; a step of manufacturing a porosity biodegrade polymer support; a step of reforming a hydrophobic surface to a hydrophilic property after plasma-processing a porosity biodegrade polymer support with reactive gas; a step of fixing a heparin in an activated carboxyl group; a step of combining bioactive substance in a heparin fixed on the surface of a porosity biodegrade polymer support; a step of including a cytotropism of different kind and a bioactive substance with a superior cell blastogenesis in inside of each polymer support.
Abstract translation: 目的：提供一种智能孔隙度生物降解聚合物支持体及其制造方法，其可以在生物组织中诱导从干细胞到原位的肌肉骨骼组织再生。 构成：智能孔隙率生物降解聚合物载体的制造方法包括以下步骤：获得在内部含有生物活性物质的聚合物样品的步骤; 制造孔隙率生物降解聚合物载体的步骤; 在用活性气体等离子体处理孔隙率生物降解聚合物载体之后，将疏水性表面重整为亲水性的步骤; 将肝素固定在活性羧基中的步骤; 将固定在孔隙率生物降解聚合物载体表面上的肝素中的生物活性物质组合的步骤; 在每个聚合物载体的内部包括不同种类的细胞嗜性和具有优异的细胞胚发生的生物活性物质的步骤。
-
22.发明公开생분해성 및 생체친화성이 우수한 조직재생용 주입형 온도감응성 플루로닉 유도체 하이드로겔 및 이의 제조방법 有权具有高生物降解性和组织再生的生物活性的可注射的热致生物衍生水合物及其制备方法
公开(公告)号：KR1020100044607A
公开(公告)日：2010-04-30
申请号：KR1020080103809
申请日：2008-10-22
Applicant: 한국과학기술연구원
IPC: C08G65/332 , C08G65/26 , C08J3/075
Abstract: PURPOSE: A pluronic derivative hydrogel is provided to ensure excellent biodegradability while maintaining thermosensitivity of a pluronic polymer, to improve cell proliferation and cell differentiation, and to be useful for generating artificial tissue or organs. CONSTITUTION: An injectable thermosensitive pluronic derivative hydrogel has a biodegradable polymer introduced to one side or both sides of the pluronic polymer. Methacryloxyethyl trimellitic anhydride is bonded to the biodegradable polymer. A physioactive material is polymerized to a carboxyl group of the methacryloxyethyl trimellitic anhydride. The pluronic polymer has a structure of polyethylene oxide-polypropylene oxide-polyethylene oxide.
Abstract translation: 目的：提供pluronic衍生物水凝胶以确保优异的生物降解性，同时保持普流聚合物的热敏性，改善细胞增殖和细胞分化，并且可用于产生人造组织或器官。 构成：可注射的热敏聚醚衍生物水凝胶具有引入聚合物聚合物的一侧或两侧的可生物降解的聚合物。 甲基丙烯酰氧基乙基偏苯三酸酐与可生物降解的聚合物结合。 生物活性物质聚合成甲基丙烯酰氧基乙基偏苯三酸酐的羧基。 聚醚聚合物具有聚环氧乙烷 - 聚环氧丙烷 - 聚环氧乙烷的结构。
-
公开(公告)号：KR101737548B1
公开(公告)日：2017-05-18
申请号：KR1020150116841
申请日：2015-08-19
Applicant: 한국과학기술연구원
Abstract: 본발명은조직재생용지지체및 이의제조방법에관한것이다. 일양태에따른조직재생용지지체는생분해성고분자및 세포외기질을이용함으로써조직재생용지지체에요구되는적절한물리적강도및 세포부착및 분화를촉진시키는최적의세포친화적환경을제공할수 있다.
Abstract translation: 组织再生纸支撑体及其制造方法技术领域本发明涉及组织再生纸支撑体及其制造方法。 根据一个实施方案的组织再生纸滞后可以通过使用可生物降解的聚合物和细胞外基质提供适当的细胞友好环境，其促进组织再生纸滞后所需的适当物理强度和细胞粘附和分化。
-
-
25.发明公开가교화된 PVA-ECM 복합체를 제조하는 방법 및 그에 의하여 제조된 PVA-ECM 복합체 有权PVA-ECM PVA-ECM由此生产交联PVA-ECM复合材料和PVA-ECM复合材料的方法
公开(公告)号：KR1020160135596A
公开(公告)日：2016-11-28
申请号：KR1020150069126
申请日：2015-05-18
Applicant: 한국과학기술연구원
CPC classification number: A61L27/3687 , A61L27/48 , A61L27/52 , A61L2430/20 , C08L89/00 , C08L29/04
Abstract: 가교화된 PVA-ECM 복합체를제조하는방법및 그에의하여제조된 PVA-ECM 복합체가제공된다.
Abstract translation: 提供了一种生产交联PVA-ECM复合材料的方法和使用该方法制备的PVA-ECM复合材料。
-
Patent Agency Ranking
-
公开(公告)号：KR1020130040748A
公开(公告)日：2013-04-24
申请号：KR1020120113833
申请日：2012-10-12
Applicant: 한국과학기술연구원
CPC classification number: C12N5/0062 , A61K35/28 , A61K35/32 , C12N2533/90
Abstract: PURPOSE: A method for preparing a self-assembled extracellular matrix and a use thereof are provided to obtain the self-assembled extracellular matrix with a nanofiber. CONSTITUTION: A method for preparing a self-assembled extracellular matrix comprises: a step of culturing cells on a two-dimensional surface to prepare an extracellular matrix; and a step of decellularizing the cells and preparing the extracellular matrix from the two-dimensional surface. The cell is an autologous cell or a stem cell.
Abstract translation: 目的：提供一种制备自组装细胞外基质的方法及其用途，以获得具有纳米纤维的自组装细胞外基质。 构成：制备自组装细胞外基质的方法包括：在二维表面上培养细胞以制备细胞外基质的步骤; 以及使细胞脱细胞化并从二维表面制备细胞外基质的步骤。 细胞是自体细胞或干细胞。
-
公开(公告)号：KR101161151B1
公开(公告)日：2012-07-02
申请号：KR1020090115872
申请日：2009-11-27
Applicant: 한국과학기술연구원
Abstract: 본 발명은 (a) 코팅 용액을 분사 노즐에 공급하는 공정, (b) 고전압을 인가하여 상기 코팅 용액을 하전시키는 공정, 및 (c) 하전된 코팅 용액을 분사 노즐을 이용하여 분사하여 스텐트 또는 생체 이식물의 표면을 코팅하는 공정을 포함하는, 스텐트 또는 생체 이식물의 표면 코팅 방법, 상기 방법에 이용되는 전기 분사 코팅 장치, 및 표면 코팅된 스텐트 또는 생체 이식물의 제조 방법에 관한 것이다. 본 발명에서는 코팅 두께를 나노미터부터 마이크로미터 수준까지 조절할 수 있고, 다층 구조의 코팅을 형성시킬 수 있으며, 약물 방출형 기능성 코팅을 할 수 있으므로, 다양한 물질의 표면을 코팅하여 부가 가치가 높은 스텐트 또는 생체 이식물을 제공할 수 있다.
스텐트, 생체 이식물, 전기 분사, 코팅, 고분자, 약물, 생리 활성 물질-
公开(公告)号：KR1020110051579A
公开(公告)日：2011-05-18
申请号：KR1020090108221
申请日：2009-11-10
Applicant: 한국과학기술연구원
CPC classification number: B05D7/14 , A61L27/00 , A61L27/28 , A61L27/34 , A61L31/10 , A61L2400/12 , A61L2400/18 , B05D1/18 , B05D3/142 , Y10T428/273 , Y10T428/31678 , C08L67/04
Abstract: PURPOSE: A method for manufacturing a surface-modified metal substrate is provided to simplify process and to reduce production cost. CONSTITUTION: A surface-modified metal substrate contains a metal substrate and polymer layer which is chemically conjugated to the surface through oxygen atoms. A method for manufacturing the surface-modified metal substrate comprises: a step of introducing a hydroxy group to the surface of the metal substrate; a step of polymerizing monomers on the surface to chemically bind polymers onto the surface through oxygen atoms. The metal is selected from stainless steel, covalt-chrome, titanium, nitinol, gold, silver, platinum, tantalum, magnesium, and metal alloy thereof.
Abstract translation: 目的：提供一种制造表面改性金属基材的方法，以简化工艺并降低生产成本。 构成：表面改性的金属基材含有金属基材和通过氧原子与表面化学偶合的聚合物层。 制造表面改性金属基材的方法包括：将羟基引入金属基材的表面的步骤; 在表面上聚合单体以通过氧原子将聚合物化学结合到表面上的步骤。 金属选自不锈钢，钴铬，钛，镍钛诺，金，银，铂，钽，镁及其金属合金。
-
公开(公告)号：KR1020110023399A
公开(公告)日：2011-03-08
申请号：KR1020090081256
申请日：2009-08-31
Applicant: 한국과학기술연구원
CPC classification number: A61L24/106 , A61L24/0015 , A61L24/04 , A61L24/08 , A61L33/126
Abstract: PURPOSE: An intelligent fibrin bio-adhesive with superior hemostasis effect and mechanical properties is provided to obtain an anti-bacteria property by adding natural polymer and/or antibiotics. CONSTITUTION: Fibrin and natural polymer form crosslinkage, and interpenetrating network or semi-interpenetrating network is obtained. The natural polymer is one or more selected from a group including alginate, chitosan, chitin, cellulose, agarose, amylase, dextran, proteoglycan, glycosaminoglycan, collagen, gelatin, heparin, hyaluronic acid, pectin, carrageena, chondroitin sulfate, dextran sulfate, polylysine, pullulan, carboxylmethyl chitin, and the salt of the same. Antibiotics are additionally introduced into the interpenetrating network or the semi-interpenetrating network.
Abstract translation: 目的：提供具有优异止血效果和机械性能的智能纤维蛋白生物粘合剂，通过加入天然聚合物和/或抗生素获得抗细菌性能。 构成：纤维蛋白和天然聚合物形成交联，获得互穿网络或半互穿网络。 天然聚合物是选自藻酸盐，壳聚糖，壳多糖，纤维素，琼脂糖，淀粉酶，葡聚糖，蛋白聚糖，糖胺聚糖，胶原，明胶，肝素，透明质酸，果胶，角叉菜胶，硫酸软骨素，硫酸葡聚糖，聚赖氨酸 ，支链淀粉，羧甲基甲壳质及其盐。 抗生素还被引入到互穿网络或半互穿网络中。
-
-
-
-
-
-
-
-
-
Search Results
61
records
(took 0.034 seconds)
