세포내 전달을 위한 올리고뉴클레오티드와 친수성 고분자로 구성되는 유전자 전달용 접합체, 고분자 전해질 복합 미셀 및 그의 제조방법
    21.
    发明公开
    세포내 전달을 위한 올리고뉴클레오티드와 친수성 고분자로 구성되는 유전자 전달용 접합체, 고분자 전해질 복합 미셀 및 그의 제조방법 有权
    包含寡核苷酸和水解聚合物用于基因转移,杂交多重复合细胞的结合及其制备方法

    公开(公告)号:KR1020030070449A

    公开(公告)日:2003-08-30

    申请号:KR1020020009993

    申请日:2002-02-25

    Inventor: 정지훈 박태관

    CPC classification number: C12N15/10

    Abstract: PURPOSE: Conjugates comprising oligonucleotide and hydrophilic polymers for gene transfer, hybrid polyion complex micelles and preparation methods thereof are provided, thereby effectively transferring the oligonucleotide within a cell, and exhibiting the activity of antisense oligonucleotide at relatively low concentration. CONSTITUTION: Conjugates comprising oligonucleotide and hydrophilic polymers for gene transfer are provided, wherein the terminal group of the oligonucleotide is covalently coupled to the hydrophilic polymers; the hydrophilic polymer is selected from nonionic polymers having the molecular weight of 500; the molecular weight of oligonucleotide is selected from between 1,000 to 50,000; the hydrophilic polymer is selected from polyethyleneglycol, polyvinylpyrrolidone, and polyoxazoline; the bond between oligonucleotide and hydrophilic polymer is selected from amide bond, carbamate bond, hydrazone bond, phosphoroamidate bond, acetal bond, disulfide bond, ester bond, and anhydride bond; and the antisense oligonucleotide comprises a portion or the total of c-myc, c-myb, c-fos, or c-jun.

    Abstract translation: 目的:提供包含用于基因转移的寡核苷酸和亲水性聚合物的缀合物,杂合聚糖复合物胶束及其制备方法,从而有效地将寡核苷酸转移到细胞内,并以相当低的浓度显示出反义寡核苷酸的活性。 构成:提供包含用于基因转移的寡核苷酸和亲水性聚合物的缀合物,其中寡核苷酸的末端基团与亲水性聚合物共价偶联; 亲水性聚合物选自分子量为500的非离子聚合物; 寡核苷酸的分子量选自1,000至50,000; 亲水性聚合物选自聚乙二醇,聚乙烯吡咯烷酮和聚恶唑啉; 寡核苷酸和亲水性聚合物之间的键选自酰胺键,氨基甲酸酯键,腙键,氨基磷酸酯键,缩醛键,二硫键,酯键和酸酐键; 并且反义寡核苷酸包含c-myc,c-myb,c-fos或c-jun的一部分或全部。

    고체산화물 연료전지 및 그 제조 방법
    23.
    发明授权
    고체산화물 연료전지 및 그 제조 방법 有权
    固体氧化物燃料电池及其制造方法

    公开(公告)号:KR101146681B1

    公开(公告)日:2012-05-22

    申请号:KR1020100009068

    申请日:2010-02-01

    CPC classification number: Y02P70/56

    Abstract: 본 발명은 밀봉 성능을 높인 고체산화물 연료전지용 단위셀, 이를 포함하는 고체산화물 연료전지 및 그 제조 방법에 관한 것으로서, 더욱 상세하게 경사부가 형성된 연료극을 이용하여 하측 면을 제외한 전 영역 또는 금속지지체의 상면 영역까지 얇은 전해질층을 용이하게 형성할 수 있어 실링성을 향상할 수 있으며, 제조 효율을 높일 수 있는 밀봉 성능을 높인 고체산화물 연료전지용 단위셀, 이를 포함하는 고체산화물 연료전지 및 그 제조 방법에 관한 것이다.

    금속폼 지지체를 사용하는 고체산화물 연료전지 및 그 제조방법
    24.
    发明公开
    금속폼 지지체를 사용하는 고체산화물 연료전지 및 그 제조방법 有权
    多金属支持的SOFC及其制造方法

    公开(公告)号:KR1020120031036A

    公开(公告)日:2012-03-29

    申请号:KR1020120013447

    申请日:2012-02-09

    CPC classification number: Y02P70/56 H01M8/12 H01M8/02

    Abstract: PURPOSE: A manufacturing method of a solid oxide fuel cell is provided to preserve pores formed on a metal foam support during process, thereby manufacturing a solid oxide fuel having excellent strength and flexibility. CONSTITUTION: A manufacturing method of a solid oxide fuel cell comprises: a first step of injecting complementary material(22) into pores(21) of metal foam support(20); a second step for forming an adhesive layer on the metal foam support; a step of laminating fuel electrode(40) on the adhesive layer; and a step of sintering the adhesive layer for contacting the metal foam support and the fuel electrode. The manufacturing method additionally comprises a step of removing the complementary material after the second step. A solid oxide fuel cell comprises a metal foam support in which pores are formed, and a single cell with a fuel electrode.

    Abstract translation: 目的:提供固体氧化物燃料电池的制造方法,以在工艺过程中保持在金属泡沫支撑体上形成的孔,从而制造具有优异强度和柔性的固体氧化物燃料。 构成:固体氧化物燃料电池的制造方法包括:向金属泡沫支撑体(20)的孔(21)注入互补材料(22)的第一步骤。 用于在所述金属泡沫支撑体上形成粘合剂层的第二步骤; 将粘合剂层上的燃料电极(40)层叠的工序; 以及烧结粘合剂层以接触金属泡沫支撑体和燃料电极的步骤。 制造方法另外包括在第二步骤之后去除互补材料的步骤。 固体氧化物燃料电池包括其中形成有孔的金属泡沫支撑体和具有燃料电极的单电池。

    밀봉재를 이용하여 단전지를 고정한 연료전지 및 그 제조 방법
    25.
    发明公开
    밀봉재를 이용하여 단전지를 고정한 연료전지 및 그 제조 방법 有权
    固定具有密封材料的电池的燃料电池及其制造方法

    公开(公告)号:KR1020110138539A

    公开(公告)日:2011-12-28

    申请号:KR1020100058473

    申请日:2010-06-21

    CPC classification number: Y02P70/56 H01M8/02 C03C3/00 C04B37/02 H01M2/08

    Abstract: PURPOSE: A unit cells-fixed fuel cell using a sealing material is provided to firmly fix the metal plate and the cell and to prevent the leakage of supplying fuel by air-tightening a gap between a metal plate and the cell. CONSTITUTION: A unit cells-fixed fuel cell includes unit cells(30) with fuel electrodes, a metal plate(10), and a sealing material(40). The metal plate includes a receiving part(16), a loading part(15), and a groove(14). The receiving part receives the unit cells. The loading part forms the bottom of the receiving part, and the unit cells are loaded on the loading part. The groove is arranged between sidewalls and the loading part. The sealing material is arranged between the unit cells and the metal plate to fix the unit cells to the metal plate. A gap(18) is arranged between the metal plate and sidewalls. The sealing material is filled in the groove through the gap.

    Abstract translation: 目的:提供使用密封材料的单元电池固定式燃料电池,以牢固地固定金属板和电池,并通过气压金属板和电池之间的间隙来防止供应燃料的泄漏。 构成:单元电池固定的燃料电池包括具有燃料电极的单元电池(30),金属板(10)和密封材料(40)。 金属板包括接收部分(16),装载部分(15)和凹槽(14)。 接收部分接收单位单元。 装载部分形成接收部分的底部,并且单元电池被装载在装载部件上。 凹槽设置在侧壁和装载部分之间。 密封材料布置在单元电池和金属板之间,以将单元电池固定在金属板上。 间隙(18)布置在金属板和侧壁之间。 密封材料通过间隙填充在凹槽中。

    열전대를 포함한 연료전지 및 그 제조방법
    26.
    发明公开
    열전대를 포함한 연료전지 및 그 제조방법 有权
    包含热电偶的燃料电池及其制造方法

    公开(公告)号:KR1020110131377A

    公开(公告)日:2011-12-07

    申请号:KR1020100050782

    申请日:2010-05-31

    CPC classification number: Y02P70/56 H01M8/12 G01K7/02 H01M8/02

    Abstract: PURPOSE: A fuel cell is provided to measure temperature in stack by inserting a plurality of thermocouple in each cell, thereby real time controlling the supply and the composition of fuel gas when operating. CONSTITUTION: A manufacturing method of a fuel cell including thermo-couple comprises: a step forming insulating layer(11) on the upper part of the electrolyte layer(10); a step forming electrode(13) functioning the hot junction of thermo-couple in upper part of the insulating layer, and forming lead wire(12) for applying electric current with the electrode; a step expanding the insulating layer to cover the electrode and the lead wire by using material which is same to the material of the insulating layer; a step forming a fuel electrode(14) on the insulating layer; and a step forming air electrode(15) under the electrolyte layer.

    Abstract translation: 目的:通过在每个电池中插入多个热电偶来提供燃料电池来测量堆叠温度,从而实时控制燃料气体的供应和组成。 构成:包括热电偶的燃料电池的制造方法包括:在电解质层(10)的上部形成台阶形成绝缘层(11); 形成电极(13),其在所述绝缘层的上部中对所述热电偶的热连接起作用,并且形成用于与所述电极一起施加电流的引线(12); 通过使用与绝缘层的材料相同的材料,使绝缘层膨胀以覆盖电极和引线的步骤; 在绝缘层上形成燃料极(14)的步骤; 以及在电解质层下方形成空气电极(15)的台阶。

    금속폼 지지체를 사용하는 고체산화물 연료전지 및 그 제조방법
    27.
    发明公开
    금속폼 지지체를 사용하는 고체산화물 연료전지 및 그 제조방법 无效
    多金属支持的SOFC及其制造方法

    公开(公告)号:KR1020110126786A

    公开(公告)日:2011-11-24

    申请号:KR1020100046239

    申请日:2010-05-18

    CPC classification number: Y02P70/56 H01M8/12 H01M8/04

    Abstract: PURPOSE: A method for manufacturing a solid oxide fuel cell is provided to prevent the loss by the damage caused by mechanical strength and impact and to obtain a solid oxide fuel cell in which the weight is reduced. CONSTITUTION: A solid oxide fuel cell comprises a metal foam supporter(20) in which pores(21) are formed and a unit cell including a fuel electrode(40). A method for manufacturing a solid oxide fuel cell comprises the steps of: flowing in a complementary material(22) in the pores of the metal foam supporter; forming an adhesive layer to the metal foam supporter; laminating the fuel electrode of the unit cell to the adhesive layer; and sintering the adhesive layer in order to mutually contact the metal foam supporter and the fuel electrode.

    Abstract translation: 目的:提供一种制造固体氧化物型燃料电池的方法,以防止由机械强度和冲击引起的损伤的损失,并获得重量降低的固体氧化物燃料电池。 构成:固体氧化物燃料电池包括其中形成孔(21)的金属泡沫支撑体(20)和包括燃料电极(40)的单元电池。 一种制造固体氧化物燃料电池的方法包括以下步骤:在金属泡沫支撑体的孔中流动互补材料(22); 向所述金属泡沫支撑体形成粘合剂层; 将单电池的燃料电极层压到粘合剂层上; 并且将粘合剂层烧结以便与金属泡沫支持体和燃料电极相互接触。

    올리고뉴클레오티드 혼성화 미셀 및 그의 제조방법
    28.
    发明公开
    올리고뉴클레오티드 혼성화 미셀 및 그의 제조방법 有权
    寡核苷酸的混合细胞及其生产

    公开(公告)号:KR1020030014958A

    公开(公告)日:2003-02-20

    申请号:KR1020010048880

    申请日:2001-08-14

    Inventor: 박태관 정지훈

    CPC classification number: A61K47/6907 A61K47/549 A61K47/593

    Abstract: PURPOSE: A process for preparing mixed micelles containing oligonucleotide and aliphatic polyester-based polymers is provided. Whereby, the mixed micelles can effectively deliver the oligonucleotide, which is used in gene therapy, into cells and the release amount thereof can be easily controlled. CONSTITUTION: An aliphatic polyester-based biodegradable polymer and an activating agent react. The reaction product is dried, mixed with oligonucleotide containing an amine group at the 5'-terminus in a mole ratio of 2:1 to 1:2 and then reacts in an organic solvent to produce a conjugate. The conjugate is dispersed in distilled water to produce a micelle. The aliphatic polyester-based biodegradable polymer is polylactic acid, polyglycolic acid, poly(D,L-lactic acid-co-glycolic acid), polycaprolactone, polyvalero-lactone, polyhydroxy butylate, polyhydroxy valerate or a mixture thereof.

    Abstract translation: 目的:提供一种制备含有寡核苷酸和脂族聚酯基聚合物的混合胶束的方法。 由此,混合胶束可以将基因治疗中使用的寡核苷酸有效地递送到细胞中,并且可以容易地控制其释放量。 构成:脂肪族聚酯基生物降解聚合物和活化剂反应。 将反应产物干燥,在5'-末端以2:1至1:2的摩尔比混合含有胺基的寡核苷酸,然后在有机溶剂中反应产生共轭物。 将缀合物分散在蒸馏水中以产生胶束。 脂肪族聚酯类生物降解性聚合物是聚乳酸,聚乙醇酸,聚(D,L-乳酸 - 共 - 乙醇酸),聚己内酯,聚戊烯 - 内酯,聚羟基丁酸酯,多羟基戊酸酯或其混合物。

    공간적 상관성이 있는 상향링크 시스템에서 최소 길이의 파일럿 시퀀스 설계 방법 및 장치
    29.
    发明授权
    공간적 상관성이 있는 상향링크 시스템에서 최소 길이의 파일럿 시퀀스 설계 방법 및 장치 有权
    减少引导序列设计方法和空间相关上行链路系统的设备

    公开(公告)号:KR101598879B1

    公开(公告)日:2016-03-15

    申请号:KR1020150010393

    申请日:2015-01-22

    CPC classification number: H04L25/021 H04L25/025 H04L25/03968

    Abstract: 공간적상관성이있는상향링크시스템에서최소길이의파일럿시퀀스설계방법및 장치가개시된다. 셀룰러통신환경에서상향링크의채널을추정하는파일럿시퀀스설계방법에있어서, 채널간의공간적상관성이있는경우, 랭크축소(rank reduction)된채널공분산행렬의부분행렬을설계하는단계, 설계된부분행렬을기초로랭크축소가된 경우와안 된경우를각각채널의부분공간정사영을이용하여최소제곱추정량을산출하고, 상기산출된최소제곱추정량을이용하여평균제곱오차를산출하는단계, 산출된 MSE를비교하여랭크축소가된 경우와안 된경우중 이득이높은경우를판단하는단계및 판단된경우의 MSE를기초로 MSE의합을최소화하는문제를목적함수를파일럿행렬에대해미분을하여파일럿신호를설계하는단계를포함한다.

    Abstract translation: 公开了一种空间相关上行链路系统中最小长度的导频序列设计方法及其方法。 用于估计蜂窝通信环境中的上行链路信道的导频序列设计方法包括以下步骤:如果在信道之间存在空间相关性,则设计其中执行秩降低的信道协方差矩阵的子矩阵; 通过使用根据秩降低的每个通道的子空间投影来计算最小二乘估计器,通过使用所计算的MSE,基于所设计的子矩阵和均方误差(MSE)而执行或不执行; 通过比较所计算的MSE,确定执行秩降低的两种情况之间具有增益增益的情况; 以及通过区分关于问题的导频矩阵的目标函数来设计导频信号,以便基于所确定的MSE来最小化MSE的总和。

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