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公开(公告)号：WO2010127284A2
公开(公告)日：2010-11-04
申请号：PCT/US2010033231
申请日：2010-04-30
Applicant: ABBOTT LAB , GHAYUR TARIQ , LIU JUNJIAN , KINGSBURY GILLIAN A , REILLY EDWARD B , MORGAN-LAPPE SUSAN E
Inventor： GHAYUR TARIQ , LIU JUNJIAN , KINGSBURY GILLIAN A , REILLY EDWARD B , MORGAN-LAPPE SUSAN E
IPC: A61K39/395 , C12P21/06
CPC classification number: C07K16/2863 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/6879 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K16/2809 , C07K16/40 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/74 , G01N2333/71
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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22.发明申请METHOD OF PREVENTING OR TREATING ORGAN, HEMATOPOIETIC STEM CELL OR BONE MARROW TRANSPLANT REJECTION 审中-公开预防或治疗器官，HEMATOPOIETIC干细胞或骨髓移植物移植的方法
公开(公告)号：WO2008064116A2
公开(公告)日：2008-05-29
申请号：PCT/US2007084959
申请日：2007-11-16
Applicant: ABBOTT LAB , BARDWELL PHILIP , GHAYUR TARIQ , GU JIJIE
Inventor： BARDWELL PHILIP , GHAYUR TARIQ , GU JIJIE
IPC: A61K31/44
CPC classification number: A61K31/44
Abstract: Methods of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection are disclosed.
Abstract translation: 公开了预防或治疗器官，造血干细胞或骨髓移植排斥的方法。
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公开(公告)号：WO0202773A3
公开(公告)日：2002-08-22
申请号：PCT/US0120755
申请日：2001-06-28
Applicant: ABBOTT LAB , COLLINSON ALBERT , GHAYUR TARIQ , AVGERINOS GEORGE , DIXON RICHARD , KAYMAKCALAN ZEHRA
Inventor： COLLINSON ALBERT , GHAYUR TARIQ , AVGERINOS GEORGE , DIXON RICHARD , KAYMAKCALAN ZEHRA
IPC: G01N33/50 , A61K39/395 , A61K47/48 , A61K49/00 , A61P1/04 , A61P17/06 , A61P25/00 , A61P29/00 , A61P37/06 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/68 , A61K51/10 , C12N15/63 , G01N33/577
CPC classification number: C07K16/245 , A61K47/6845 , A61K2039/505 , C07K14/545 , C07K16/46 , C07K16/468 , C07K2317/10 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , G01N33/6869
Abstract: Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1 alpha and IL-1 beta and neutralize IL-1 alpha and IL-1 beta activity in vitro and in vivo . An antibody of the inventi on can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting two different but structurally related antigens (e.g., IL-1 alpha and IL-1 beta ) and for inhibiting the activity of the antigens, (e.g., in a human subject suffering from a disorder in which IL-1 alpha and/or IL-1 beta activity is detrimental.
Abstract translation: 提供了对两种不同但结构相关抗原具有双重特异性的抗体。 抗体可以是例如完全是人抗体，重组抗体或单克隆抗体。 优选的抗体对IL-1α和IL-1β具有双重特异性，并在体外和体内中和IL-1α和IL-1β活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测两种不同但结构相关的抗原（例如，IL-1α和IL-1β）并用于抑制抗原的活性（例如，在受试者的受试者中 来自其中IL-1α和/或IL-1β活性是有害的病症。
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公开(公告)号：WO2012061374A3
公开(公告)日：2012-11-01
申请号：PCT/US2011058769
申请日：2011-11-01
Applicant: ABBOTT LAB , GHAYUR TARIQ , LIU JUNJIAN , GU JIJIE , HARRIS MARIA C
Inventor： GHAYUR TARIQ , LIU JUNJIAN , GU JIJIE , HARRIS MARIA C
IPC: C12P21/08 , A61K39/395 , C07K16/00
CPC classification number: C07K16/468 , A61K2039/505 , C07K16/22 , C07K16/241 , C07K16/26 , C07K16/2863 , C07K16/2875 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/567 , C07K2317/60 , C07K2317/64 , C07K2317/71 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
Abstract translation: 提供了工程化的多价和多特异性结合蛋白，制备方法以及它们在疾病的预防，诊断和/或治疗中的用途。
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公开(公告)号：WO2012027570A4
公开(公告)日：2012-07-19
申请号：PCT/US2011049147
申请日：2011-08-25
Applicant: ABBOTT LAB , GHAYUR TARIQ , SALFELD JOCHEN G , MCPHERSON MICHAEL J
Inventor： GHAYUR TARIQ , SALFELD JOCHEN G , MCPHERSON MICHAEL J
CPC classification number: G01N33/53 , A61K2039/505 , C07K16/18 , C07K16/22 , C07K16/241 , C07K2317/24 , C07K2317/626 , C07K2317/64 , C07K2317/76
Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
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Patent Agency Ranking
公开(公告)号：WO2011163478A3
公开(公告)日：2012-05-03
申请号：PCT/US2011041633
申请日：2011-06-23
Applicant: ABBOTT LAB , GHAYUR TARIQ , LIU JUNJIAN , JAKWAY JAMES J , TALANIAN ROBERT V , BENATUIL LORENZO
Inventor： GHAYUR TARIQ , LIU JUNJIAN , JAKWAY JAMES J , TALANIAN ROBERT V , BENATUIL LORENZO
IPC: A61K39/395 , C07K16/00 , C12P21/02
CPC classification number: C07K16/2875 , C07K16/241 , C07K16/468 , C07K2317/31 , C07K2317/64
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：WO2011047262A4
公开(公告)日：2011-11-10
申请号：PCT/US2010052843
申请日：2010-10-15
Applicant: ABBOTT LAB , GHAYUR TARIQ , KAMATH RAJESH V , LIU JUNJIAN , HONORE MARIE P
Inventor： GHAYUR TARIQ , KAMATH RAJESH V , LIU JUNJIAN , HONORE MARIE P
CPC classification number: C07K16/00 , C07K16/22 , C07K16/241 , C07K16/245 , C07K16/2866 , C07K16/44 , C07K16/46 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/73 , C07K2317/76
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：WO2011028811A3
公开(公告)日：2011-04-28
申请号：PCT/US2010047543
申请日：2010-09-01
Applicant: ABBOTT LAB , GHAYUR TARIQ , LIU JUNJIAN , MANOJ SHARMILA , BROPHY SUSAN E
Inventor： GHAYUR TARIQ , LIU JUNJIAN , MANOJ SHARMILA , BROPHY SUSAN E
CPC classification number: C07K16/468 , A61K45/06 , C07K16/00 , C07K16/2803 , C07K16/2809 , C07K16/2863 , C07K16/2887 , C07K16/30 , C07K16/44 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/515 , C07K2317/64 , C07K2317/732 , C07K2317/92
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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29.发明申请PROSTAGLANDIN E2 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF 审中-公开PROSTAGLANDIN E2双变量域免疫球蛋白及其用途
公开(公告)号：WO2010006060A3
公开(公告)日：2010-06-03
申请号：PCT/US2009049954
申请日：2009-07-08
Applicant: ABBOTT LAB , GHAYUR TARIQ , GU JIJIE , ISAKSON PETER C
Inventor： GHAYUR TARIQ , GU JIJIE , ISAKSON PETER C
CPC classification number: C07K16/468 , A61K38/00 , A61K45/06 , A61K47/6879 , A61K51/109 , C07K16/22 , C07K16/24 , C07K16/26 , C07K16/2863 , C07K16/2866 , C07K16/44 , C07K2317/31 , C07K2317/64 , C07K2317/73 , C07K2317/732 , C07K2317/734 , G01N33/6869 , G01N33/74 , G01N33/88 , G01N2333/4709 , G01N2333/48 , G01N2333/525 , G01N2333/5443 , G01N2333/545 , G01N2333/7155
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。
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公开(公告)号：WO2007024715A3
公开(公告)日：2008-10-30
申请号：PCT/US2006032398
申请日：2006-08-18
Applicant: ABBOTT LAB , WU CHENGBIN , GHAYUR TARIQ , DIXON RICHARD W , SALFELD JOCHEN G
Inventor： WU CHENGBIN , GHAYUR TARIQ , DIXON RICHARD W , SALFELD JOCHEN G
CPC classification number: C07K16/241 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/244 , C07K16/28 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/64 , C07K2317/94
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，特别涉及它们在预防和/或治疗急性和慢性炎症和其他疾病中的用途。
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