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公开(公告)号：AU2004202769A1
公开(公告)日：2004-07-15
申请号：AU2004202769
申请日：2004-06-23
Applicant: ABBOTT LAB BERMUDA LTD
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公开(公告)号：PT929578E
公开(公告)日：2003-09-30
申请号：PT97906572
申请日：1997-02-10
Applicant: ABBOTT LAB BERMUDA LTD
Inventor： WHITE MICHAEL , WILTON ALISON JANE , SALFELD JOCHEN G , ALLEN DEBORAH J , KAYMAKCALAN ZEHRA , LABKOVSKY BORIS , MANKOVICH JOHN A , MCGUINESS BRIAN T , ROBERTS ANDREW J , SAKORAFAS PAUL , HOOGENBOOM HENDRICUS R J M , SCHOENHAUT DAVID , VAUGHAN TRISTAN J
IPC: C12N15/09 , A61K31/00 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/505 , A61K31/517 , A61K31/52 , A61K31/529 , A61K31/57 , A61K31/573 , A61K31/675 , A61K38/00 , A61K38/04 , A61K38/16 , A61K39/39 , A61K39/395 , A61P1/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P7/00 , A61P7/04 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/16 , A61P13/12 , A61P17/00 , A61P17/02 , A61P19/02 , A61P19/06 , A61P25/00 , A61P27/02 , A61P29/02 , A61P31/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P33/06 , A61P35/00 , A61P35/04 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P39/02 , C07K16/24 , C12N1/21 , C12N5/10 , C12P21/08 , G01N33/53 , G01N33/543 , G01N33/564 , G01N33/576 , G01N33/68 , C12N15/13 , C12N15/64
Abstract: Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor α (hTNFα) are disclosed. These antibodies have high affinity for hTNFα (e.g., Kd=10−8 M or less), a slow off rate for hTNFα dissociation (e.g., Koff=10−3 sec−1 or less) and neutralize hTNFα activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hTNFα and for inhibiting hTNFα activity, e.g., in a human subject suffering from a disorder in which hTNFα activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
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公开(公告)号：CA2628703C
公开(公告)日：2019-10-29
申请号：CA2628703
申请日：2006-11-30
Applicant: ABBOTT LAB , ABBOTT GMBH & CO KG
Inventor： BARGHORN STEFAN , EBERT ULRICH , HILLEN HEINZ , KELLER PATRICK , STRIEBINGER ANDREAS , LABKOVSKY BORIS
Abstract: Anti-A.beta. globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies. The present invention relates to anti-A.beta. globulomer antibodies having a binding affinity to A.beta.(20-42) globulomer that is greater than the binding affinity of the antibody to A.beta.(1-42) globulomer, antigen-binding moieties thereof, hybridomas producing said antibodies, nucleic acids encoding said antibodies, vectors comprising said nucleic acids, host cells comprising said vectors, methods of producing said antibodies, compositions comprising said antibodies, therapeutic and diagnostic uses of said antibodies and corresponding methods relating to Alzheimer's disease and other amyloidoses.
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公开(公告)号：CY1112893T1
公开(公告)日：2016-04-13
申请号：CY121100602
申请日：2012-07-05
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , LABKOVSKY BORIS , VOSS JEFFREY W , GREEN LARRY , BABCOOK JOHN , JIA XIAO-CHI , WIELER JAMES , KANG JASPAL SINGH , HEDBERG BRAD
Abstract: Ηπαρούσαεφεύρεσηπεριλαμβάνει IL-18-δεσμευόμενεςπρωτεΐνες, ιδίωςαντισώματαπουδεσμεύονταιμεανθρώπινηιντερλευκίνη-18 (hIL-18). Συγκεκριμένα, ηεφεύρεσησχετίζεταιμεαντισώματαπουείναιεξολοκλήρουανθρώπινααντισώματα. Ταπροτιμητέααντισώματαέχουνυψηλήσυγγένειαγια hlL-18 και/ήεξουδετερώνουνδραστικότητα hIL-18 in vitro και in vivo. Αντίσωματηςεφεύρεσηςμπορείναείναιαντίσωμαπλήρουςμήκουςή τμήμααυτούπουδεσμεύεταιμεαντιγόνο. Παρέχεταιεπίσηςμέθοδοςπαρασκευήςκαιμέθοδοςχρήσηςτωναντισωμάτωντηςεφεύρεσης. Τααντισώματα, ήτμήματααντισωμάτων, τηςεφεύρεσηςείναιχρήσιμαγιαανίχνευση hIL-18 καιγιααναστολήδραστικότητας hIL-18, π.χ. σεάνθρωποπουυποφέρειαπόδιαταραχήστηνοποίαη δραστικότητα hIL-18 είναιεπιβλαβής.
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公开(公告)号：CA2631195C
公开(公告)日：2016-04-05
申请号：CA2631195
申请日：2006-11-30
Applicant: ABBOTT LAB , ABBOTT GMBH & CO KG
Inventor： LABKOVSKY BORIS , BARGHORN STEFAN , HILLEN HEINZ , EBERT ULRICH , STRIEBINGER ANDREAS R , KELLER PATRICK
IPC: C07K16/18 , A61K39/395 , A61P25/28 , C12N5/16 , C12N5/18 , C12N15/13 , C12P21/08 , G01N33/577
Abstract: The subject invention relates to monoclonal antibodies (e.g., 8F5 and 8C5) that may be used, for example, in the prevention, treatment and diagnosis of Alzheimer's Disease or other neurodegenerative disorders.
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Patent Agency Ranking
公开(公告)号：AU2013200177A1
公开(公告)日：2013-01-31
申请号：AU2013200177
申请日：2013-01-14
Applicant: ABBOTT GMBH & CO KG , ABBOTT LAB
Inventor： LABKOVSKY BORIS , STRIEBINGER ANDREAS R , EBERT ULRICH , KELLER PATRICK , BARGHORN STEFAN , HILLEN HEINZ
IPC: C07K16/18 , A61K39/395 , A61P25/28 , C12N5/18 , C12N15/13 , G01N33/53 , G01N33/577
Abstract: MONOCLONAL ANTIBODIES AGAINST AMYLOID BETA PROTEIN AND USES THEREOF The subject invention relates to monoclonal antibodies (e.g., 8F5 and 8C5) that may be used, for example, in the prevention, treatment and diagnosis of Alzheimer's Disease or other neurodegenerative disorders.
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公开(公告)号：DK1685152T3
公开(公告)日：2012-07-30
申请号：DK04817825
申请日：2004-11-12
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , LABKOVSKY BORIS , VOSS JEFFREY W , GREEN LARRY , BABCOOK JOHN , JIA XIAO-CHI , WIELER JAMES , KANG JASPAL SINGH , HEDBERG BRAD
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公开(公告)号：ES2385484T3
公开(公告)日：2012-07-25
申请号：ES04817825
申请日：2004-11-12
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , LABKOVSKY BORIS , VOSS JEFFREY W , GREEN LARRY , BABCOOK JOHN , JIA XIAO-CHI , WIELER JAMES , KANG JASPAL SINGH , HEDBERG BRAD
Abstract: Un anticuerpo, o porción de unión al antígeno del mismo, capaz de unirse IL-18 humana, donde dicho anticuerpo, o porción de unión al antígeno del mismo, comprende una CDR-H1 que tiene los Residuos 31-35 del SEQ ID NO: 6; una CDR-H2 que tiene los Residuos 50-66 del SEQ ID NO: 6; una CDR-H3 que tiene los Residuos 99-110 del SEQ ID NO: 6; una CDR-L1 que tiene los Residuos 24-34 del SEQ ID NO: 7; una CDR-L2 que tiene los Residuos 50-56 del SEQ ID NO: 7; y una CDR-L3 que tiene los Residuos 89-98 del SEQ ID NO: 7.
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公开(公告)号：PT1685152E
公开(公告)日：2012-07-23
申请号：PT04817825
申请日：2004-11-12
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , VOSS JEFFREY W , LABKOVSKY BORIS , GREEN LARRY , BABCOOK JOHN , JIA XIAO-CHI , WIELER JAMES , KANG JASPAL SINGH , HEDBERG BRAD
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公开(公告)号：AU2011201536A1
公开(公告)日：2011-04-28
申请号：AU2011201536
申请日：2011-04-05
Applicant: ABBOTT LAB
Inventor： DUNCAN ALEXANDER ROBERT , LABKOVSKY BORIS , SHORROCK CELIA ELIZABETH , SALFELD JOCHEN , MANKOVICH JOHN , ELIZABETH THOMPSON JULIA , WHITE MICHAEL , ROGUSKA MIKE , DIXON RICHARD W , BROCKLEHURST SIMON MARK , LENNARD SIMON NICHOLAS , GHAYUR TARIQ
IPC: C12N15/02 , A61K39/395 , A61K45/00 , A61P1/04 , A61P3/10 , A61P5/14 , A61P7/00 , A61P7/02 , A61P7/06 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/06 , A61P17/14 , A61P19/02 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P39/00 , A61P39/02 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08
Abstract: Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular, antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-I8 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
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