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    REAGENTS AND METHODS FOR THE QUANTIFICATION OF IMIPRAMINE OR DESIPRAMINE IN BIOLOGICAL FLUIDS
    21.
    发明申请
    REAGENTS AND METHODS FOR THE QUANTIFICATION OF IMIPRAMINE OR DESIPRAMINE IN BIOLOGICAL FLUIDS 审中-公开
    生物流体中IMIPRAMINE或DESIPRAMINE的定量试剂和方法

    公开(公告)号：WO1993003371A1

    公开(公告)日：1993-02-18

    申请号：PCT/US1992006303

    申请日：1992-07-29

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  ADAMCZYK, Maciej ,  JOHNSON, Donald ,  HARRINGTON, Charles, A.

    IPC: G01N33/533

    CPC classification number: G01N33/533 ,  C07D223/28 ,  G01N33/9466 ,  Y10S436/815 ,  Y10S530/807

    Abstract: Immunoassay methods and reagents for the specific quantification of imipramine or desipramine in a test sample are disclosed. The measurement of imipramine or desipramine is accomplished in a specific immunoassay employing antibodies prepared with imipramine or desipramine derivatives of formula (III), wherein P is an immunogenic carrier material, X is two heteroatoms, Y is a linking group comprising from 1 to 6 carbon atoms and P is an immunogenic carrier material, and wherein for imipramine, R is CH3, and for desipramine, R is H. The present invention also describes the synthesis of unique labeled reagents of the structure of formula (IV), wherein Z is a linking group comprising 1 to 4 carbon atoms and 0 to 2 heteroatoms and Q is a detectable moiety, preferably fluorescein or a fluorescein derivative, and wherein for imipramine, R1 is CH3, and for desipramine, R1 is H.

    Abstract translation: 公开了用于在测试样品中特异性定量丙咪嗪或地昔帕明的免疫测定方法和试剂。 丙咪嗪或地昔帕明的测量是在使用由式（III）的丙咪嗪或地昔帕明衍生物制备的抗体的特异性免疫测定中完成的，其中P是免疫原性载体材料，X是两个杂原子，Y是包含1至6个碳原子的连接基团 原子和P是免疫原性载体材料，并且其中对于丙咪嗪，R是CH 3，对于地昔帕明，R是H.本发明还描述了式（IV）结构的唯一标记试剂的合成，其中Z是 包含1至4个碳原子和0至2个杂原子的连接基团，Q是可检测部分，优选荧光素或荧光素衍生物，并且其中对于丙咪嗪，R 1为CH 3，并且对于地昔帕明，R 1为H.

    REAGENTS AND METHODS FOR THE QUANTIFICATION OF AMITRIPTYLINE OR NORTRIPTYLINE IN BIOLOGICAL FLUIDS
    22.
    发明申请
    REAGENTS AND METHODS FOR THE QUANTIFICATION OF AMITRIPTYLINE OR NORTRIPTYLINE IN BIOLOGICAL FLUIDS 审中-公开
    生物流体中氨基酸或线性定量的试剂和方法

    公开(公告)号：WO1993003370A1

    公开(公告)日：1993-02-18

    申请号：PCT/US1992006302

    申请日：1992-07-29

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  ADAMCZYK, Maciej ,  JOHNSON, Donald ,  HARTTER, Darryl, E. ,  FISHPAUGH, Jeffrey, R.

    IPC: G01N33/533

    CPC classification number: C07D223/28 ,  G01N33/533 ,  G01N33/9466 ,  Y10S436/815 ,  Y10S436/816 ,  Y10S436/822 ,  Y10S436/823

    Abstract: Immunoassay methods and reagents for the specific quantification of amitriptyline or nortriptyline in a test sample are disclosed employing antibodies prepared with amitriptyline or nortriptyline derivatives of formula (III), wherein for amitriptyline, R is CH3, and for nortriptyline, R is H. The present invention also describes the synthesis of unique fluorescein tracers of the structure of formula (IV) and formula (V), wherein for a specific amitriptyline immunoassay, W1 is a heteroatom linked to the aromatic ring at the 2 or 3 position, and for a specific nortriptyline immunoassay, W2 is two heteroatoms linked together and attached to the aromatic ring at the 2 or 3 position, and wherein Q is a detectable moiety, preferably fluorescein or a fluorescein derivative.

    Abstract translation: 使用用阿米替林或式（III）的去甲替林衍生物制备的抗体公开了用于测定样品中阿米替林或去甲替林的具体定量的免疫测定方法和试剂，其中对于阿米替林，R为CH 3，对于去甲替林，R为H. 本发明还描述了式（IV）和式（V）结构的唯一荧光素示踪剂的合成，其中对于特定的阿米替林免疫测定，W1是在2或3位与芳环连接的杂原子，对于特定的 去甲替林免疫测定中，W2是两个连接在一起并连接到2或3位芳环的杂原子，其中Q是可检测部分，优选荧光素或荧光素衍生物。

    REAGENTS AND METHODS FOR THE QUANTIFICATION OF IMIPRAMINE OR DESIPRAMINE IN BIOLOGICAL FLUIDS
    25.
    发明授权
    REAGENTS AND METHODS FOR THE QUANTIFICATION OF IMIPRAMINE OR DESIPRAMINE IN BIOLOGICAL FLUIDS 失效
    试剂和方法米帕明地昔帕明或定量生物体液中

    公开(公告)号：EP0641439B1

    公开(公告)日：2000-09-13

    申请号：EP92917086.8

    申请日：1992-07-29

    Applicant: ABBOTT LABORATORIES

    Inventor： ADAMCZYK, Maciej ,  JOHNSON, Donald ,  HARRINGTON, Charles, A.

    IPC: G01N33/533 ,  G01N33/94 ,  C07D223/28

    CPC classification number: G01N33/533 ,  C07D223/28 ,  G01N33/9466 ,  Y10S436/815 ,  Y10S530/807

    Abstract: Immunoassay methods and reagents for the specific quantification of imipramine or desipramine in a test sample are disclosed. The measurement of imipramine or desipramine is accomplished in a specific immunoassay employing antibodies prepared with imipramine or desipramine derivatives of formula (III), wherein P is an immunogenic carrier material, X is two heteroatoms, Y is a linking group comprising from 1 to 6 carbon atoms and P is an immunogenic carrier material, and wherein for imipramine, R is CH3, and for desipramine, R is H. The present invention also describes the synthesis of unique labeled reagents of the structure of formula (IV), wherein Z is a linking group comprising 1 to 4 carbon atoms and 0 to 2 heteroatoms and Q is a detectable moiety, preferably fluorescein or a fluorescein derivative, and wherein for imipramine, R1 is CH3, and for desipramine, R1 is H.

    IMMUNOASSAY OF ANALYTES IN SAMPLES CONTAINING ENDOGENOUS ANTI-ANALYTE ANTIBODIES
    27.
    发明公开
    IMMUNOASSAY OF ANALYTES IN SAMPLES CONTAINING ENDOGENOUS ANTI-ANALYTE ANTIBODIES 审中-公开
    分析物与内源分析物抗体样品免疫分析

    公开(公告)号：EP2097750A2

    公开(公告)日：2009-09-09

    申请号：EP07871174.4

    申请日：2007-10-17

    Applicant: ABBOTT LABORATORIES

    Inventor： MATTINGLY, Phillip G. ,  ADAMCZYK, Maciej ,  BRASHEAR, Roy Jeffrey

    IPC: G01N33/53 ,  G01N33/543

    CPC classification number: G01N33/54393 ,  G01N33/54326 ,  G01N2800/24

    Abstract: The invention provides among other things an assay method that compensates for the presence of endogenous antibodies, e.g., autoantibodies, which might otherwise compromise the measurement of an analyte in a biological sample. In one embodiment, this method entails the use of a two labeled entities: a labeled detection agent and a labeled species-specific antibody, wherein the labeled species-specific antibody is specific for the species from which the biological sample was obtained. Sample analyte is bound by the detection agent and any anti-analyte autoantibodies present in the sample. Analyte bound by autoantibodies is detected via the species-specific antibody, optionally labeled.

    DETERMINATION OF TRICYCLIC ANTIDEPRESSANT DRUGS IN THE PRESENCE OF INTERFERING SUBSTANCES
    28.
    发明授权
    DETERMINATION OF TRICYCLIC ANTIDEPRESSANT DRUGS IN THE PRESENCE OF INTERFERING SUBSTANCES 失效
    测定中存在三环类抗抑郁药干扰物质

    公开(公告)号：EP0619020B1

    公开(公告)日：2000-11-08

    申请号：EP92905134.0

    申请日：1991-12-13

    Applicant: ABBOTT LABORATORIES

    Inventor： ADAMCZYK, Maciej ,  FISHPAUGH, Jeffrey, R. ,  HARRINGTON, Charles, A. ,  HARTTER, Daryl, E. ,  HRUSKA, Robert E.

    IPC: G01N33/50 ,  G01N33/94 ,  G01N33/53 ,  G01N30/02 ,  G01N30/22

    CPC classification number: G01N33/9466

    Abstract: Method and reagents for determining a compound of interest present in a test sample also containing one or more interfering compounds having substantially similar chemical structures, and otherwise analytically indistinguishable from each other, employing a pretreatment reagent capable of selectively modifying the chemical structure of one of the compounds without significantly modifying or altering the chemical structure of the other one of the compounds. The selective modification results in the modified compound having a chemical structure which is substantially dissimilar to the chemical structure of the other one of said compounds wherein the compounds are substantially distinguishable from each other to permit the analytical determination of one or the other of such compounds by immunoassay, high pressure liquid chromatography, and thin layer chromatography techniques, especially for the fluorescent polarization immunoassay determination of tricyclic antidepressant drugs in the presence of phenothiazines.

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