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    REAGENTS AND METHODS FOR THE DETECTION AND QUANTIFICATION OF VANCOMYCIN IN BIOLOGICAL FLUIDS
    1.
    发明申请
    REAGENTS AND METHODS FOR THE DETECTION AND QUANTIFICATION OF VANCOMYCIN IN BIOLOGICAL FLUIDS 审中-公开
    VANCOMYCIN在生物流体中检测和定量的试剂和方法

    公开(公告)号：WO1996031780A1

    公开(公告)日：1996-10-10

    申请号：PCT/US1996004469

    申请日：1996-04-01

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  ADAMCZYK, Maciej ,  BRATE, Elaine, M. ,  PERKOWITZ, Mary, M. ,  REGE, Sushil, D.

    IPC: G01N33/94

    CPC classification number: C07K16/44 ,  G01N33/533 ,  G01N33/9446 ,  Y10T436/10

    Abstract: Immunoassay reagents, methods and test kits for the specific quantification of vancomycin in a test sample are disclosed. The reagent comprises antibodies prepared with immunogens of Figure 6 wherein P is an immunogenic carrier material and X is a linking moiety. Also described is the synthesis of labeled reagents of Figure 8 wherein Q is a detectable moiety, preferably fluorescein or a fluorescein derivative, and X is a linking moiety.

    Abstract translation: 公开了用于测试样品中万古霉素的特异性定量的免疫测定试剂，方法和测试试剂盒。 试剂包含用图6的免疫原制备的抗体，其中P是免疫原性载体材料，X是连接部分。 还描述了图8的标记试剂的合成，其中Q是可检测部分，优选荧光素或荧光素衍生物，X是连接部分。

    REAGENTS AND METHODS FOR THE DETECTION AND QUANTIFICATION OF TESTOSTERONE IN FLUID SAMPLES
    3.
    发明申请
    REAGENTS AND METHODS FOR THE DETECTION AND QUANTIFICATION OF TESTOSTERONE IN FLUID SAMPLES 审中-公开
    流体样品中TESTOSTERONE检测和定量的试剂和方法

    公开(公告)号：WO1995004283A1

    公开(公告)日：1995-02-09

    申请号：PCT/US1994008604

    申请日：1994-08-01

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  ADAMCZYK, Maciej ,  CHEN, Yon-Yih ,  WALLING, John, A. ,  JAMES, Bryan, D. ,  ARTRIP, Sharon, G.

    IPC: G01N33/74

    CPC classification number: G01N33/53 ,  C07J1/0022 ,  C07K16/26 ,  G01N33/743 ,  Y02P20/55 ,  Y10S435/81 ,  Y10S435/962 ,  Y10S435/968 ,  Y10S436/817 ,  Y10S436/822 ,  Y10S530/812

    Abstract: The present invention discloses novel immunogens, antibodies prepared from such immunogens, and labeled reagents useful in immunoassays for the detection and quantification of testosterone in a test sample. Also disclosed are immunoassays using these reagents and methods for synthesizing these reagents. The immunoassays are preferably microparticle enzyme immunoassays (MEIAs) and fluorescence polarization immunoassays (FPIAs). Further discloded are novel starting materials for making the above novel immunogens and labeled reagents. Methods for making the novel immunogens and labeled reagents from the novel starting materials are also disclosed.

    Abstract translation: 本发明公开了由免疫原制备的新型免疫原，抗体以及用于免疫测定的标记试剂，用于检测和定量测试样品中的睾酮。 还公开了使用这些试剂的免疫测定法和合成这些试剂的方法。 免疫测定优选为微粒酶免疫测定（MEIAs）和荧光偏振免疫测定（FPIAs）。 进一步揭示了制备上述新型免疫原和标记试剂的新型起始材料。 还公开了从新型起始材料制备新型免疫原和标记试剂的方法。

    MATERIALS AND METHODS FOR IMMUNOASSAY OF PTERINS
    4.
    发明申请
    MATERIALS AND METHODS FOR IMMUNOASSAY OF PTERINS 审中-公开
    材料与方法免疫杂交

    公开(公告)号：WO2012064674A1

    公开(公告)日：2012-05-18

    申请号：PCT/US2011/059652

    申请日：2011-11-07

    Applicant: ABBOTT LABORATORIES ,  ADAMCZYK, Maciej ,  BRASHEAR, R., Jeffrey ,  HSU, Stephen, C. ,  MATTINGLY, Phillip, G.

    Inventor： ADAMCZYK, Maciej ,  BRASHEAR, R., Jeffrey ,  HSU, Stephen, C. ,  MATTINGLY, Phillip, G.

    IPC: G01N33/53 ,  C07D475/04

    CPC classification number: C07D475/04 ,  C07D487/14 ,  C09B15/00 ,  G01N33/5308

    Abstract: Methods of assaying for (i) a pterin by immunoassay employing a pterin as capture agent, (ii) neopterin by chemiluminescent microparticle immunoassay (CMIA) employing an anti-neopterin antibody (Ab) as capture agent, (iii) neopterin by an immunoassay (IA) employing an acridinium (Acr)-labeled anti-neopterin Ab as conjugate, and (iv) neopterin by an IA employing Acr-labeled neopterin as tracer; an Acr-labeled anti-neopterin Ab; a conjugate/complex comprising anti-neopterin Ab and a carrier scaffold; a conjugated pterin; a conjugate comprising an Acr-labeled pterin and a carrier scaffold; an immunogen comprising neopterin and a carrier protein; a conjugate comprising such an immunogen and an Acr compound; an immunogen comprising a carrier protein and a neopterin hapten; a conjugate comprising such an immunogen and an Acr compound; a kit for assaying a pterin comprising a pterin as a capture agent and instructions for IA; and a kit for assaying neopterin comprising an anti-neopterin Ab as a capture agent and instructions for CMIA, neopterin comprising an Acr-labeled anti-neopterin Ab as a conjugate and instructions for IA, or Acr-labeled neopterin as a tracer and instructions for IA.

    Abstract translation: 通过使用蝶呤作为捕获剂的免疫测定来测定（i）蝶呤的方法，（ii）使用抗新蝶呤抗体（Ab）作为捕获剂的化学发光微粒免疫测定（CMIA）的新蝶呤，（iii）通过免疫测定法的新蝶呤 IA），使用吖啶（Acr）标记的抗新蝶呤Ab作为缀合物，和（iv）通过使用Acr标记的新蝶呤作为示踪剂的IA的新蝶呤; Acr标记的抗新蝶呤Ab; 包含抗新蝶呤Ab和载体支架的缀合物/复合物; 共轭蝶呤 缀合物，其包含Acr标记的蝶呤和载体支架; 包含新蝶呤和载体蛋白的免疫原; 包含这种免疫原和Acr化合物的缀合物; 包含载体蛋白和新蝶呤半抗原的免疫原; 包含这种免疫原和Acr化合物的缀合物; 用于测定包含蝶呤作为捕获剂的蝶呤的试剂盒和用于IA的说明书; 以及用于测定包含抗新蝶呤Ab作为捕获剂的新蝶呤的试剂盒，以及CMIA指令，包含Acr标记的抗新蝶呤Ab作为缀合物的新蝶呤，以及用于IA或Acr标记的新蝶呤作为示踪剂的说明书 IA。

    ASSAY FOR CARDIAC TROPONIN-T (cTnT)
    5.
    发明申请
    ASSAY FOR CARDIAC TROPONIN-T (cTnT) 审中-公开
    CARDIAC TROPONIN-T（cTnT）测定

    公开(公告)号：WO2011068681A1

    公开(公告)日：2011-06-09

    申请号：PCT/US2010/057004

    申请日：2010-11-17

    Applicant: ABBOTT LABORATORIES ,  ADAMCZYK, Maciej ,  BRASHEAR, Jeffrey, R ,  MATTINGLY, Phillip, G.

    Inventor： ADAMCZYK, Maciej ,  BRASHEAR, Jeffrey, R ,  MATTINGLY, Phillip, G.

    IPC: G01N33/50 ,  G01N33/53

    CPC classification number: G01N33/6893 ,  G01N2333/4712 ,  G01N2800/32 ,  G01N2800/324

    Abstract: The present disclosure describes immunoassays for detecting cardiac troponin-T (cTnT) in a test sample, and in particular immunoassays and kits for detecting cTnT in a test sample suspected of containing substances that may interfere with the determination of cTnT, such as heterophilic endogenous antibodies and autoantibodies to cTnT. The methods use more than one capture phase antibody and more than one detection antibody to improve specificity, and provide for the use of humanized immunoreagents to overcome heterophillic antibody interferences.

    Abstract translation: 本公开描述了用于检测测试样品中的心肌肌钙蛋白-T（cTnT）的免疫测定，特别是用于检测疑似含有可能干扰cTnT的测定的物质的测试样品中的cTnT的免疫测定和试剂盒，例如异嗜内源性抗体 和cTnT的自身抗体。 该方法使用多于一种捕获相抗体和多于一种检测抗体来改善特异性，并提供使用人源化免疫反应物来克服嗜异性抗体干扰。

    METHODS AND KITS FOR DETECTING HEMOGLOBIN IN TEST SAMPLES
    6.
    发明申请
    METHODS AND KITS FOR DETECTING HEMOGLOBIN IN TEST SAMPLES 审中-公开
    检测样品中HEMOGLOBIN的方法和试剂盒

    公开(公告)号：WO2010093482A1

    公开(公告)日：2010-08-19

    申请号：PCT/US2010/020095

    申请日：2010-01-05

    Applicant: ABBOTT LABORATORIES ,  ADAMCZYK, Maciej ,  BRASHEAR, Roy, Jeffrey ,  MATTINGLY, Phillip, G.

    Inventor： ADAMCZYK, Maciej ,  BRASHEAR, Roy, Jeffrey ,  MATTINGLY, Phillip, G.

    IPC: G01N33/72

    CPC classification number: G01N21/76 ,  G01N33/721

    Abstract: The present invention relates to methods of detecting hemoglobin in a test sample. These methods can be used to diagnose a subject suffering from a genetic disorder relating to hemoglobin metabolism, to determine the eligibility of a subject to be a blood donor, to determine the age of a stored blood sample or to identify a hemolyzed plasma sample. The present invention also relates to kits for use in the above described methods. The methods involve the use of a basic solution and either an acridinium compound or an electrode.

    Abstract translation: 本发明涉及检测试样中血红蛋白的方法。 这些方法可以用于诊断患有与血红蛋白代谢相关的遗传疾病的受试者，以确定受试者是献血者的资格，以确定储存的血液样品的年龄或鉴定溶血的血浆样品。 本发明还涉及用于上述方法的试剂盒。 所述方法包括使用碱性溶液和吖啶鎓化合物或电极。

    ISOLATED HUMAN AUTOANTIBODIES TO NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) AND METHODS AND KITS FOR THE DETECTION OF HUMAN AUTOANTIBODIES TO NGAL
    7.
    发明申请
    ISOLATED HUMAN AUTOANTIBODIES TO NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) AND METHODS AND KITS FOR THE DETECTION OF HUMAN AUTOANTIBODIES TO NGAL 审中-公开
    分离的人类自身抗体与中性粒细胞相关的利培酮（NGAL）以及将人类自身抗体检测到NGAL的方法和工具

    公开(公告)号：WO2010048354A1

    公开(公告)日：2010-04-29

    申请号：PCT/US2009/061580

    申请日：2009-10-22

    Applicant: ABBOTT LABORATORIES ,  ADAMCZYK, Maciej ,  BRASHEAR, Roy Jeffrey ,  MATTINGLY, Phillip G.

    Inventor： ADAMCZYK, Maciej ,  BRASHEAR, Roy Jeffrey ,  MATTINGLY, Phillip G.

    IPC: G01N33/564

    CPC classification number: G01N33/564

    Abstract: A method of determining the presence, amount or concentration of at least one autoantibody that reacts with neutrophil gelatinase-associated lipocalin (NGAL), alone or in further combination with a method of determining the concentration of NGAL, which methods can further comprise diagnosing, prognosticating, or assessing the efficacy of a therapeutic/prophylactic treatment of a patient and, optionally, modifying the therapeutic/prophylactic treatment of the patient as needed to improve efficacy; a kit comprising at least one component for assaying a test sample for at least one autoantibody that reacts with NGAL and instructions for assaying; a method of isolating an autoantibody that reacts with NGAL; an isolated autoantibody that reacts with NGAL; and a method for determining the reliability of an NGAL assay result.

    Abstract translation: 一种确定与嗜中性粒细胞明胶酶相关脂质运载蛋白（NGAL）反应的至少一种自身抗体的存在，量或浓度的方法，其单独或与确定NGAL浓度的方法进一步组合，所述方法可进一步包括诊断，预后 ，或评估治疗/预防性治疗患者的功效，以及任选地根据需要修改患者的治疗/预防性治疗以改善功效; 一种试剂盒，其包含用于测定与NGAL反应的至少一种自身抗体的测试样品和用于测定的说明书的至少一种组分; 分离与NGAL反应的自身抗体的方法; 与NGAL反应的分离的自身抗体; 以及用于确定NGAL测定结果的可靠性的方法。

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