公开(公告)号：EP0876388B1

公开(公告)日：2004-02-18

申请号：EP96936579.0

申请日：1996-10-17

Applicant: Abbott Laboratories

Inventor： OR, Yat, Sun ,  PHAN, Ly, Tam ,  CHU, Daniel, T. ,  SPINA, Kenneth, P. ,  HALLAS, Robert ,  ELLIOTT, Richard, L.

IPC: C07H17/08 ,  A61K31/70

CPC classification number: C07H17/08

公开(公告)号：EP1027361B1

公开(公告)日：2003-05-07

申请号：EP98956314.3

申请日：1998-10-29

Applicant: Abbott Laboratories

Inventor： OR, Yat, Sun ,  GRIESGRABER, George ,  LI, Leping ,  CHU, Daniel, T.

IPC: C07H17/00 ,  A61K31/70

CPC classification number: C07H17/08

Abstract: Novel 6,11-bridged erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II); compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier; a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention; and processes for their preparation.

公开(公告)号：EP1017706A1

公开(公告)日：2000-07-12

申请号：EP98947047.1

申请日：1998-09-15

Applicant: Abbott Laboratories

Inventor： OR, Yat, Sun ,  CLARK, Richard, F. ,  CHU, Daniel, T.

IPC: C07H17/08 ,  A61K31/70

CPC classification number: C07H17/08

Abstract: Disclosed are the antibacterial compounds having formulas (I) or (II) or pharmaceutically acceptable salts and esters thereof. Also disclosed are the processes for preparing compounds of formulas (I), and (II) of the invention, pharmaceutical compositions comprising a therapeutically effective amount of a compound of the invention in combination with pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention.

公开(公告)号：EP0984975A1

公开(公告)日：2000-03-15

申请号：EP98923678.1

申请日：1998-05-22

Applicant: Abbott Laboratories

Inventor： OR, Yat, Sun ,  GRIESGRABER, George, W. ,  CHU, Daniel, T.

IPC: C07H17/08 ,  A61K31/70

CPC classification number: C07H17/08 ,  Y02P20/55

Abstract: Novel multicyclic erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formulae (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), or (XI), pharmaceutical compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formula (I).

Abstract translation: 具有式（I），（II），（III），（IV），（V），（VI），（VII），（VIII），（IX）的新的具有抗菌活性的多环红霉素化合物及其药学上可接受的盐和酯， ），（X）或（XI）的药物组合物，包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物，以及通过向哺乳动物施用药物组合物来治疗细菌感染的方法， 治疗有效量的式（I）化合物。

公开(公告)号：EP0874863A1

公开(公告)日：1998-11-04

申请号：EP96940766.0

申请日：1996-11-06

Applicant: ABBOTT LABORATORIES

Inventor： OR, Yat, Sun ,  CHU, Daniel, T. ,  ELLIOTT, Richard, L. ,  PIREH, Daisy

IPC: A61K31 ,  A61P31 ,  C07H17

CPC classification number: C07H17/08

Abstract: A compound selected from groups (I), (II), and (III), wherein A, B, V, W, X and R8 are specifically defined; pharmaceutical compositions thereof; a method of treating or preventing bacterial infections by administering therapeutically effective pharmaceutical compositions thereof; and a process for the preparation thereof.

Abstract translation: 选自组（I），（II）和（III）的化合物，其中A，B，V，W，X和R8具体定义; 其药物组合物; 通过给予其治疗有效的药物组合物治疗或预防细菌感染的方法; 及其制备方法。

公开(公告)号：EP1027362B1

公开(公告)日：2005-06-29

申请号：EP98956338.2

申请日：1998-10-29

Applicant: Abbott Laboratories

Inventor： PHAN, LY, Tam ,  OR, Yat, Sun ,  CHU, Daniel, T. ,  PLATTNER, Jacob, J. ,  CHEN, Yan ,  CLARK, Richard, F.

IPC: C07H17/08 ,  A61K31/70

CPC classification number: C07H17/08 ,  Y02P20/55

Abstract: Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.

公开(公告)号：EP0984975B1

公开(公告)日：2003-04-23

申请号：EP98923678.1

申请日：1998-05-22

Applicant: Abbott Laboratories

Inventor： OR, Yat, Sun ,  GRIESGRABER, George, W. ,  CHU, Daniel, T.

IPC: C07H17/08 ,  A61K31/70

CPC classification number: C07H17/08 ,  Y02P20/55

Abstract: Novel multicyclic erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formulae (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), or (XI), pharmaceutical compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formula (I).

公开(公告)号：EP0874863B1

公开(公告)日：2003-01-29

申请号：EP96940766.7

申请日：1996-11-06

Applicant: ABBOTT LABORATORIES

Inventor： OR, Yat, Sun ,  CHU, Daniel, T. ,  ELLIOTT, Richard, L. ,  PIREH, Daisy

IPC: C07H17/08 ,  A61K31/70

CPC classification number: C07H17/08

Abstract: A compound selected from groups (I), (II), and (III), wherein A, B, V, W, X and R are specifically defined; pharmaceutical compositions thereof; a method of treating or preventing bacterial infections by administering therapeutically effective pharmaceutical compositions thereof; and a process for the preparation thereof.

Abstract translation: 选自组（I），（II）和（III）的化合物，其中A，B，V，W，X和R8具体定义; 其药物组合物; 通过给予其治疗有效的药物组合物治疗或预防细菌感染的方法; 及其制备方法。

公开(公告)号：EP1027361A1

公开(公告)日：2000-08-16

申请号：EP98956314.3

申请日：1998-10-29

Applicant: Abbott Laboratories

Inventor： OR, Yat, Sun ,  GRIESGRABER, George ,  LI, Leping ,  CHU, Daniel, T.

IPC: C07H17/00 ,  A61K31/70

CPC classification number: C07H17/08

Abstract: Novel 6,11-bridged erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II); compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier; a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention; and processes for their preparation.

公开(公告)号：EP0971919A1

公开(公告)日：2000-01-19

申请号：EP98904979.6

申请日：1998-02-06

Applicant: Abbott Laboratories

Inventor： WANG, Wei-Bo ,  KERDESKY, Francis, A., J. ,  HSIAO, Chi-Nung, W. ,  LI, Qun ,  CHU, Daniel, T.

IPC: C07D455/02

CPC classification number: C07D455/02

Abstract: A process for the preparation of a compound having formula (a) wherein R?1, R2, R3, R4, and R5¿ are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.