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公开(公告)号：WO1997017357A1
公开(公告)日：1997-05-15
申请号：PCT/US1996017892
申请日：1996-11-06
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , OR, Yat, Sun , CHU, Daniel, T. , ELLIOTT, Richard, L. , PIREH, Daisy
IPC: C07H17/08
CPC classification number: C07H17/08
Abstract: A compound selected from groups (I), (II), and (III), wherein A, B, V, W, X and R are specifically defined; pharmaceutical compositions thereof; a method of treating or preventing bacterial infections by administering therapeutically effective pharmaceutical compositions thereof; and a process for the preparation thereof.
Abstract translation: 选自基团（I），（II）和（III）的化合物，其中A，B，V，W，X和R 8是具体定义的; 其药物组合物; 通过施用其治疗有效的药物组合物来治疗或预防细菌感染的方法; 及其制备方法。
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2.发明申请PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 审中-公开作为DIPPTIDYL PEPTIDASE-IV（DPP-IV）的抑制剂的药物组合物
公开(公告)号：WO2004026822A2
公开(公告)日：2004-04-01
申请号：PCT/US2003/029018
申请日：2003-09-15
Applicant: ABBOTT LABORATORIES
Inventor： MADAR, David , PEI, Zhonghua , PIREH, Daisy , DJURIC, Stevan, W. , WIEDEMAN, Paul, E. , YONG, Hong , FEENSTRA, Melissa, J. , KOPECKA, Hana , LI, Xiaofeng , LONGENECKER, Kenton , SHAM, Hing, L. , STEWART, Kent, D. , SZCZEPANKIEWICZ, Bruce, G.
IPC: C07D207/00
CPC classification number: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
Abstract: The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
Abstract translation: 本发明涉及抑制二肽基肽酶IV（DPP-IV）的化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，X综合征，高胰岛素血症，肥胖症，动脉粥样硬化和各种免疫调节疾病 。
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3.发明申请3-DESCLADINOSE-2,3-ANHYDROERYTHROMYCIN DERIVATIVES 审中-公开3-DESCLADINOSE-2,3-ANHYDROERYZROMYCIN DERIVATIVES
公开(公告)号：WO1997042205A1
公开(公告)日：1997-11-13
申请号：PCT/US1997007051
申请日：1997-04-25
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , ELLIOTT, Richard, L. , OR, Yat, Sun , CHU, Daniel, T. , GRIESGRABER, George, W. , PLATTNER, Jacob, J. , PIREH, Daisy
IPC: C07H17/08
Abstract: Novel 3-descladinose-2,3-anhydroerythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity selected from the group consisting of: (a) (I), (b) (II), (c) (III), and (d) (IV), pharmaceutical compositions comprising a therapeutically effective amount of a compound of formulas (I)-(IV) of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formulas (I)-(IV) of the invention.
Abstract translation: 具有选自：（a）（I），（b）（II），（c）（III））和（c）（III）的组中的具有抗菌活性的新型3-缩水甘油-2,3-脱水红霉素化合物及其药学上可接受的盐和酯 （d）（IV），包含治疗有效量的本发明式（I） - （IV）化合物与药学上可接受的载体组合的药物组合物，以及通过给予 哺乳动物含有治疗有效量的本发明式（I） - （IV）化合物的药物组合物。
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公开(公告)号：EP0574494A1
公开(公告)日：1993-12-22
申请号：EP92906944.0
申请日：1992-02-14
Applicant: ABBOTT LABORATORIES
Inventor： SUMMERS, James, B. , SHEPPARD, George, S. , PHILLIPS, James, G. , PIREH, Daisy , STEINMAN, Douglas, H. , MAY, Paul, D. , GUINN, Denise, E. , HEYMAN, H., Robin , CARRERA, George, M., Jr. , DAVIDSEN, Steven, K.
CPC classification number: C07D409/14 , C07D417/14
Abstract: L'invention se rapporte à des composés d'indole, qui sont substitués aux positions 1 ou 3 par un groupe (pyrid-3-yl)thiazolid-4-yl alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- ou (pyrid-3-yl)dithiolan-4-oyl)- et qui constituent de puissants inhibiteurs du facteur d'activation des plaquettes et sont utiles dans le traitement des troubles associés au facteur d'activation des plaquettes, tels que choc septique, syndrome de la détresse respiratoire, inflammations aiguës, immunité cellulaire retardée, parturition, maturation des poumons du foetus et différenciation cellulaire.
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公开(公告)号：EP0874863B1
公开(公告)日：2003-01-29
申请号：EP96940766.7
申请日：1996-11-06
Applicant: ABBOTT LABORATORIES
Inventor： OR, Yat, Sun , CHU, Daniel, T. , ELLIOTT, Richard, L. , PIREH, Daisy
CPC classification number: C07H17/08
Abstract: A compound selected from groups (I), (II), and (III), wherein A, B, V, W, X and R are specifically defined; pharmaceutical compositions thereof; a method of treating or preventing bacterial infections by administering therapeutically effective pharmaceutical compositions thereof; and a process for the preparation thereof.
Abstract translation: 选自组（I），（II）和（III）的化合物，其中A，B，V，W，X和R8具体定义; 其药物组合物; 通过给予其治疗有效的药物组合物治疗或预防细菌感染的方法; 及其制备方法。
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Patent Agency Ranking6.发明授权PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 有权药物组合物及其用途作为二肽基肽酶IV抑制剂（DPP-IV）
公开(公告)号：EP1560811B9
公开(公告)日：2008-03-05
申请号：EP03774478.6
申请日：2003-09-15
Applicant: ABBOTT LABORATORIES
Inventor： MADAR, David , PEI, Zhonghua , PIREH, Daisy , DJURIC, Stevan, W. , WIEDEMAN, Paul, E. , YONG, Hong , MICHMERHUIZEN, Melissa, J. , KOPECKA, Hana , LI, Xiaofeng , LONGENECKER, Kenton , SHAM, Hing, L. , STEWART, Kent, D. , SZCZEPANKIEWICZ, Bruce, G.
IPC: C07D207/00
CPC classification number: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R1,R2 and R3 have the definitions given in the description.
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公开(公告)号：EP0922050B1
公开(公告)日：2003-07-30
申请号：EP97921411.1
申请日：1997-04-25
Applicant: ABBOTT LABORATORIES
Inventor： ELLIOTT, Richard, L. , OR, Yat, Sun , CHU, Daniel, T. , GRIESGRABER, George, W. , PLATTNER, Jacob, J. , PIREH, Daisy
Abstract: Novel 3-descladinose-2,3-anhydroerythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity selected from the group consisting of: (a) (I), (b) (II), (c) (III), and (d) (IV), pharmaceutical compositions comprising a therapeutically effective amount of a compound of formulas (I)-(IV) of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formulas (I)-(IV) of the invention.
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公开(公告)号：EP0922050A1
公开(公告)日：1999-06-16
申请号：EP97921411.0
申请日：1997-04-25
Applicant: ABBOTT LABORATORIES
Inventor： ELLIOTT, Richard, L. , OR, Yat, Sun , CHU, Daniel, T. , GRIESGRABER, George, W. , PLATTNER, Jacob, J. , PIREH, Daisy
Abstract: Novel 3-descladinose-2,3-anhydroerythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity selected from the group consisting of: (a) (I), (b) (II), (c) (III), and (d) (IV), pharmaceutical compositions comprising a therapeutically effective amount of a compound of formulas (I)-(IV) of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formulas (I)-(IV) of the invention.
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9.发明授权PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 有权药物组合物及其用途作为二肽基肽酶IV抑制剂（DPP-IV）
公开(公告)号：EP1560811B1
公开(公告)日：2007-08-01
申请号：EP03774478.6
申请日：2003-09-15
Applicant: ABBOTT LABORATORIES
Inventor： MADAR, David , PEI, Zhonghua , PIREH, Daisy , DJURIC, Stevan, W. , WIEDEMAN, Paul, E. , YONG, Hong , MICHMERHUIZEN, Melissa, J. , KOPECKA, Hana , LI, Xiaofeng , LONGENECKER, Kenton , SHAM, Hing, L. , STEWART, Kent, D. , SZCZEPANKIEWICZ, Bruce, G.
IPC: C07D207/00
CPC classification number: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R1,R2 and R3 have the definitions given in the description.
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10.发明公开PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 有权药物组合物及其用途作为二肽基肽酶IV抑制剂（DPP-IV）
公开(公告)号：EP1560811A2
公开(公告)日：2005-08-10
申请号：EP03774478.6
申请日：2003-09-15
Applicant: Abbott Laboratories
Inventor： MADAR, David , PEI, Zhonghua , PIREH, Daisy , DJURIC, Stevan, W. , WIEDEMAN, Paul, E. , YONG, Hong , FEENSTRA, Melissa, J. , KOPECKA, Hana , LI, Xiaofeng , LONGENECKER, Kenton , SHAM, Hing, L. , STEWART, Kent, D. , SZCZEPANKIEWICZ, Bruce, G.
IPC: C07D207/00
CPC classification number: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R1,R2 and R3 have the definitions given in the description.
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