公开(公告)号：EP0876353A1

公开(公告)日：1998-11-11

申请号：EP96943605.0

申请日：1996-12-06

Applicant: Abbott Laboratories

Inventor： SHAM, Hing, Leung ,  STEWART, Kent, D. ,  KEMPF, Dale, J.

IPC: C07D253 ,  A61K31 ,  A61P31 ,  C07D207 ,  C07D233 ,  C07D239 ,  C07D241 ,  C07D263 ,  C07D401 ,  C07D403 ,  C07D405 ,  C07D409 ,  C07D417

CPC classification number: C07D207/404 ,  C07D207/27 ,  C07D207/408 ,  C07D233/32 ,  C07D233/36 ,  C07D233/42 ,  C07D239/10 ,  C07D239/22 ,  C07D241/08 ,  C07D241/18 ,  C07D253/06 ,  C07D263/22 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12

Abstract: Inhibitors of HIV protease are provided. When bound to HIV protease, the inhibitors are characterized by a unique three-dimensional conformation and orientation relative to the S1, S1', S2, S2', S3, and S3' subsites of the protease. Pharmaceutical compositions containing the inhibitors and methods of treating HIV infection are also provided.

公开(公告)号：EP1891072B1

公开(公告)日：2012-01-11

申请号：EP06759877.1

申请日：2006-05-16

Applicant: ABBOTT LABORATORIES

Inventor： GRACIAS, Vijaya, J. ,  ABAD-ZAPATERO, Celerino ,  DJURIC, Stevan, W. ,  JI, Zhiqin ,  MICHAELIDES, Michael, R. ,  STEWART, Kent, D. ,  ZANZE, Irini

IPC: C07D487/04 ,  A61K31/551

CPC classification number: C07D487/04

Abstract: Compounds having the Formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：EP2203431B1

公开(公告)日：2011-08-10

申请号：EP08832330.8

申请日：2008-09-17

Applicant: Abbott Laboratories

Inventor： FLENTGE, Charles, A. ,  HUTCHINSON, Douglas, K. ,  BETEBENNER, David, A. ,  DEGOEY, David, A. ,  DONNER, Pamela, L. ,  KATI, Warren, M. ,  KRUEGER, Allan, C. ,  LIU, Dachun ,  LIU, Yaya ,  LONGENECKER, Kenton, L. ,  MARING, Clarence, J. ,  MOTTER, Christopher, E. ,  PRATT, John, K. ,  RANDOLPH, John, T. ,  ROCKWAY, Todd, W. ,  STEWART, Kent, D. ,  WAGNER, Rolf ,  BARNES, David, M. ,  CHEN, Shuang ,  FRANCZYK, Thaddeus, S., II ,  GAO, Yi ,  HAIGHT, Anthony, R. ,  HENGEVELD, John, E. ,  KOTECKI, Brian, J. ,  LOU, Xiaochun ,  ZHANG, Geoff, G., Z.

IPC: C07D239/22 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  A61K31/513 ,  A61P31/12

CPC classification number: C07D239/54 ,  A61K31/513 ,  A61K45/06 ,  C07D239/22 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  A61K2300/00

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.