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1.发明申请
公开(公告)号：WO2006124813A3
公开(公告)日：2006-11-23
申请号：PCT/US2006/018796
申请日：2006-05-16
Applicant: ABBOTT LABORATORIES , GRACIAS, Vijaya, J. , ABAD-ZAPATERO, Celerino , DJURIC, Stevan, W. , JI, Zhiqin , MICHAELIDES, Michael, R. , STEWART, Kent, D. , ZANZE, Irini
Inventor： GRACIAS, Vijaya, J. , ABAD-ZAPATERO, Celerino , DJURIC, Stevan, W. , JI, Zhiqin , MICHAELIDES, Michael, R. , STEWART, Kent, D. , ZANZE, Irini
IPC: C07D487/04 , A61K31/551 , A61P35/00
Abstract: Compounds having the Formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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公开(公告)号：WO2003080625A1
公开(公告)日：2003-10-02
申请号：PCT/US2003/008647
申请日：2003-03-20
Applicant: ABBOTT LABORATORIES
Inventor： MICHAELIDES, Michael, R. , DAI, Yujia , DAVIDSEN, Steven, K. , FREY, Robin, R. , GUO, Yan , JI, Zhiqin , CURTIN, Michael
IPC: C07D495/04
CPC classification number: C07D495/04 , C07D513/04
Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
Abstract translation: 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。
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公开(公告)号：WO2003080064A1
公开(公告)日：2003-10-02
申请号：PCT/US2003/008950
申请日：2003-03-21
Applicant: ABBOTT LABORATORIES , HIRST, Gavin, C. , ARNOLD, Lee, D. , BURCHAT, Andrew , WISHART, Neil , CALDERWOOD, David , WADA, Carol, K. , MICHAELIDES, Michael, R. , JI, Zhiqin , MUCKEY, Melanie
Inventor： HIRST, Gavin, C. , ARNOLD, Lee, D. , BURCHAT, Andrew , WISHART, Neil , CALDERWOOD, David , WADA, Carol, K. , MICHAELIDES, Michael, R. , JI, Zhiqin , MUCKEY, Melanie
IPC: A61K31/519
CPC classification number: C07D487/04 , C07D491/04
Abstract: The present application is directed to pyrazolopyrimidine and furopyrimidine analogs of the formula (I), wherein the substituents are as defined herein, which are useful as kinase inhibitors.
Abstract translation: 本申请涉及式（I）的吡唑并嘧啶和呋喃嘧啶类似物，其中取代基如本文所定义，其可用作激酶抑制剂。
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公开(公告)号：WO2009136966A1
公开(公告)日：2009-11-12
申请号：PCT/US2008/086336
申请日：2008-12-11
Applicant: ABBOTT LABORATORIES , MICHAELIDES, Michael R. , JI, Zhiqin
Inventor： MICHAELIDES, Michael R. , JI, Zhiqin
IPC: C07D487/04 , A61K31/53 , A61P35/00
CPC classification number: C07D487/04
Abstract: Compounds that inhibit Aurora-kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. One embodiment of this invention, therefore, pertains to compounds that inhibit Aurora-kinases, the compounds having formula I and therapeutically acceptable salts thereof.
Abstract translation: 公开了抑制极光激酶的化合物，含有化合物的组合物和使用该化合物治疗疾病的方法。 因此，本发明的一个实施方案涉及抑制极光激酶的化合物，具有式I的化合物及其治疗上可接受的盐。
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公开(公告)号：WO2004113304A1
公开(公告)日：2004-12-29
申请号：PCT/US2004/016166
申请日：2004-05-21
Applicant: ABBOTT LABORATORIES , DAI, Yujia , DAVIDSEN, Steven, K. , ERICSSON, Anna, M. , HARTANDI, Kresna , JI, Zhiqin , MICHAELIDES, Michael, R.
Inventor： DAI, Yujia , DAVIDSEN, Steven, K. , ERICSSON, Anna, M. , HARTANDI, Kresna , JI, Zhiqin , MICHAELIDES, Michael, R.
IPC: C07D231/56
CPC classification number: C07D231/56 , C07D261/20 , C07D275/04 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/04 , Y02P20/582
Abstract: Compounds having the formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
Abstract translation: 具有式（I）的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。
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Patent Agency Ranking
公开(公告)号：EP2150553B1
公开(公告)日：2011-10-05
申请号：EP08780617.0
申请日：2008-05-09
Applicant: Abbott Laboratories
Inventor： MICHAELIDES, Michael, R. , JI, Zhiqin
IPC: C07D487/04 , A61K31/4985 , A61P35/00 , A61K31/53
CPC classification number: C07D487/04
Abstract: Compounds having Formula (I) that inhibit Aurora-kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
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公开(公告)号：EP2150553A1
公开(公告)日：2010-02-10
申请号：EP08780617.0
申请日：2008-05-09
Applicant: Abbott Laboratories
Inventor： MICHAELIDES, Michael, R. , JI, Zhiqin
IPC: C07D487/04 , A61K31/4985 , A61P35/00 , A61K31/53
CPC classification number: C07D487/04
Abstract: Compounds having Formula (I) that inhibit Aurora-kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
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公开(公告)号：EP2297151A1
公开(公告)日：2011-03-23
申请号：EP08874235.8
申请日：2008-12-11
Applicant: Abbott Laboratories
Inventor： MICHAELIDES, Michael R. , JI, Zhiqin
IPC: C07D487/04 , A61K31/53 , A61P35/00
CPC classification number: C07D487/04
Abstract: Compounds that inhibit Aurora-kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. One embodiment of this invention, therefore, pertains to compounds that inhibit Aurora-kinases, the compounds having formula I and therapeutically acceptable salts thereof.
Abstract translation: 公开了抑制Aurora激酶的化合物，含有该化合物的组合物以及使用该化合物治疗疾病的方法。 因此，本发明的一个实施方案涉及抑制极光激酶，具有式I的化合物及其治疗可接受的盐的化合物。
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公开(公告)号：EP1638941B1
公开(公告)日：2010-06-02
申请号：EP04776083.0
申请日：2004-05-21
Applicant: ABBOTT LABORATORIES
Inventor： DAI, Yujia , DAVIDSEN, Steven, K. , ERICSSON, Anna, M. , HARTANDI, Kresna , JI, Zhiqin , MICHAELIDES, Michael, R.
IPC: C07D231/56 , C07D403/12 , C07D261/20 , C07D401/12 , C07D403/04 , C07D401/04 , C07D409/04 , C07D275/04 , C07D405/12 , A61K31/423 , A61K31/428 , A61P35/00 , A61K31/416
CPC classification number: C07D231/56 , C07D261/20 , C07D275/04 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/04 , Y02P20/582
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10.发明公开SUBSTITUTED 7, 8-DIHYDRO-1H-PYRIMIDO[4,5-B][1,4] DIAZEPIN-4-AMINES AS KINASE INHIBITORS 有权取代的7,8-二氢-1H-嘧啶并[4,5-B]二氮杂-4-胺作为激酶抑制剂的
公开(公告)号：EP1891072A2
公开(公告)日：2008-02-27
申请号：EP06759877.1
申请日：2006-05-16
Applicant: ABBOTT LABORATORIES
Inventor： GRACIAS, Vijaya, J. , ABAD-ZAPATERO, Celerino , DJURIC, Stevan, W. , JI, Zhiqin , MICHAELIDES, Michael, R. , STEWART, Kent, D. , ZANZE, Irini
IPC: C07D487/04
CPC classification number: C07D487/04
Abstract: Compounds having the Formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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