公开(公告)号：EP0586605B1

公开(公告)日：1998-08-05

申请号：EP92914861.7

申请日：1992-04-10

Applicant: ABBOTT LABORATORIES

Inventor： ADAMCZYK, Janina ,  BERRY, Daniel, S. ,  FICO, Rosario ,  JOU, Yi-Her ,  STROUPE, Stephen, D.

IPC: C12Q1/00 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/536 ,  G01N33/537 ,  G01N33/538 ,  G01N33/541 ,  G01N33/543 ,  G01N33/544 ,  G01N33/546 ,  G01N33/532 ,  G01N33/545

CPC classification number: G01N33/538

Abstract: This invention presents novel assay methods employing a capture reagent, involving a first binding member typically conjugated to a polymeric anion substance, and a solid phase material containing a reaction site comprising a polymeric cation substance having a nitrogen content of at least about two percent. In one embodiment a test sample suspected of containing the analyte of interest may be contacted with the capture reagent to form a charged capture reagent/analyte complex. The complex is then contacted to the oppositely charged solid phase to attract, attach, and immobilize the capture reagent/analyte complex. The use of a polycationic substance, having a nitrogen content of at least about two percent (excluding the counter ions), to prepare a suitably charged solid phase provides a solid phase that can be subjected to a greater extent of manipulation, such as multiple washes, without losing the capability to attract and retain the capture reagent.

公开(公告)号：EP0736181A1

公开(公告)日：1996-10-09

申请号：EP95906047.0

申请日：1994-12-19

Applicant: Abbott Laboratories

Inventor： WONG, Martin ,  FINLEY, David, M. ,  RAMP, John, M. ,  BOLTINGHOUSE, Gary, L., Jr. ,  SHAFFAR, Mark, R. ,  STROUPE, Stephen, D. ,  BRACKETT, John, M.

IPC: C12Q1 ,  G01N21 ,  G01N31 ,  G01N33

CPC classification number: G01N33/52 ,  C12Q1/52 ,  G01N33/84 ,  Y10S435/81 ,  Y10S435/962 ,  Y10S435/963 ,  Y10S514/836

Abstract: Detection of lead present in a sample, comprising the steps of: (a) adding a lead recovery agent to an assay solution containing lead from the sample; (b) adding to the assay solution a disulfide enzyme which is inhibited in the presence of lead; and (c) correlating the activity of the disulfide enzyme to the amount of lead in the sample. The lead recovery agent, preferably a lead chelating agent, enhances the sensitivity and accuracy of the assay such that the assay can be readily automated for detection of lead in whole blood using commercially available automation systems.

公开(公告)号：EP0566629A1

公开(公告)日：1993-10-27

申请号：EP92902803.0

申请日：1991-12-23

Applicant: ABBOTT LABORATORIES

Inventor： KHALIL, Omar, S. ,  GENGER, Kevin, R. ,  COTTER, Stephen, M. ,  JOU, Yi-Her ,  ABUNIMEH, Noman, A. ,  HILTIBRAND, Robert, G. ,  STROUPE, Stephen, D.

IPC: G01N33 ,  C12Q1

CPC classification number: G01N33/582 ,  C12Q1/6816 ,  G01N33/54313 ,  G01N33/54326

Abstract: Techniques de détermination d'analytes multiples pouvant se trouver dans un échantillon de test consistant à utiliser différents traceurs chimioluminescents à durées de vie courte et longue, à intégrer le signal de chimioluminescence généré et à procéder à une discrimination temporelle des constituants à durées de vie courte et longue du signal généré. L'invention concerne également des matériels contenant ces composés chimioluminescents à durées de vie courte et longue.

公开(公告)号：EP1038030A2

公开(公告)日：2000-09-27

申请号：EP98963112.2

申请日：1998-12-11

Applicant: ABBOTT LABORATORIES

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Stephen, D.

IPC: C12Q1/68 ,  C07K14/47 ,  C07K16/18 ,  C12N5/10 ,  G01N33/574

CPC classification number: C07K16/18 ,  C07K14/47

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PA153 and transcribed from pancreatic tissue, are described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the pancreas, such as pancreatic cancer. Also provided are antibodies which specifically bind to PA153-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PA153 polypeptide, which molecules are useful for the therapeutic treatment of pancreatic diseases, tumors or metastases.

公开(公告)号：EP1032706A1

公开(公告)日：2000-09-06

申请号：EP98958633.4

申请日：1998-11-18

Applicant: Abbott Laboratories

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Stephen, D.

IPC: C12Q1/68 ,  C07K14/47 ,  C12N5/10 ,  C12N15/12 ,  C07K16/30 ,  G01N33/574 ,  A61K39/00 ,  A61K48/00

CPC classification number: C07K14/4748 ,  A61K39/00 ,  A61K2039/51 ,  C12Q1/6886 ,  C12Q2600/136

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS265 and transcribed from breast tissue, is described. Theses sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BS265-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS265 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

公开(公告)号：EP1003779A1

公开(公告)日：2000-05-31

申请号：EP98933219.2

申请日：1998-07-07

Applicant: Abbott Laboratories

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  RUSSELL, John, C. ,  STROUPE, Stephen, D.

IPC: C07K14/47 ,  C12Q1/68 ,  G01N33/574 ,  C12N15/12 ,  C07K16/30

CPC classification number: C07K14/47 ,  C07K16/3015 ,  C07K2317/34 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57415

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS202 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BS202-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS202 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

公开(公告)号：EP0977893A1

公开(公告)日：2000-02-09

申请号：EP98919862.7

申请日：1998-04-23

Applicant: Abbott Laboratories

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Stephen, D.

IPC: C12Q1/68 ,  C07K14/47 ,  C12N5/10 ,  C07K16/00 ,  G01N33/574 ,  A61K38/17

CPC classification number: C07K16/3069 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS118 and transcribed from prostate tissue, is described. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS118-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS118 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

公开(公告)号：EP0975772A1

公开(公告)日：2000-02-02

申请号：EP98913332.7

申请日：1998-03-31

Applicant: ABBOTT LABORATORIES

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HAYDEN, Mark ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Stephen, D.

IPC: C12N15/63

CPC classification number: C07K16/3046 ,  A61K38/00 ,  C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS141 and transcribed from GI tract tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS141-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS141 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.

公开(公告)号：EP0973944A1

公开(公告)日：2000-01-26

申请号：EP98913296.4

申请日：1998-03-30

Applicant: Abbott Laboratories

Inventor： BILLING-MEDEL, Patricia, A. ,  COHEN, Maurice ,  COLPITTS, Tracey, L. ,  FRIEDMAN, Paula, N. ,  GORDON, Julian ,  GRANADOS, Edward, N. ,  HAYDEN, Mark ,  HODGES, Steven, C. ,  KLASS, Michael, R. ,  KRATOCHVIL, Jon, D. ,  ROBERTS-RAPP, Lisa ,  RUSSELL, John, C. ,  STROUPE, Stephen, D.

IPC: C12Q1/68 ,  C07K14/47 ,  C12N5/10 ,  C07K16/00 ,  G01N33/574 ,  A61K38/17

CPC classification number: G01N33/6893 ,  C07K14/47 ,  C07K16/3046 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N2800/06 ,  Y10S435/81 ,  Y10S530/828

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS198 and transcribed from GI tract tissue, is described. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS198-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS198 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.

公开(公告)号：EP0586590A1

公开(公告)日：1994-03-16

申请号：EP92913618.0

申请日：1992-04-10

Applicant: ABBOTT LABORATORIES

Inventor： ADAMCZYK, Janina ,  BERRY, Daniel, S. ,  FICO, Rosario ,  JOU, Yi-Her ,  STROUPE, Stephen, D.

IPC: G01N33

CPC classification number: G01N33/54393 ,  G01N33/538 ,  G01N33/54353 ,  G01N33/544

Abstract: Nouveaux procédés d'analyse et réactif faisant appel à un réactif de capture, mettant en jeu un membre de fixation spécifique associé à une substance anionique polymère, et un matériau en phase solide contenant une zone de capture ou de réaction comportant une substance cationique polymère. Un échantillon à analyser dans lequel on soupçonne la présence de l'analyte recherché peut être mis en contact avec le réactif de capture pour former un complexe chargé contenant le réactif de capture et l'analyte. Le complexe est ensuite mis en contact avec la phase solide de charge opposée pour attirer, fixer et immobiliser le complexe réactif de capture/analyte. Avec un réactif indicateur approprié, on peut réaliser des analyses en sandwich, compétitives et indirectes. De préférence, le réactif indicateur comprend un inhibiteur de fixation non spécifique qui permet de réduire la fixation non spécifique entre les réactifs indicateurs et la phase solide, sans gêner la réaction entre le réactif de capture et la phase solide. Les inhibiteurs de fixation non spécifiques appropriés comprennent des matériaux polyanioniques non liés ou libres tels que le sulfate de dextrane, l'héparine, le dextrane de carboxyméthyle, la cellulose de carboxyméthyle, le polysulfate de pentosane, l'hexasulfate d'inositol ou le sulfate de beta-cyclodextrine.