公开(公告)号：JPS61186372A

公开(公告)日：1986-08-20

申请号：JP2727185

申请日：1985-02-14

Applicant: AGENCY IND SCIENCE TECHN

Inventor： YASUMOTO MASAHIKO ,  YANAGIYA KOSHIN ,  KURABAYASHI MASAHIRO

IPC: C07D417/04 ,  C07D213/00 ,  C07D277/00 ,  C07D277/64 ,  C07D307/00

Abstract: PURPOSE:To obtain a benzothiazole useful as pharmaceuticals and agricultural chemicals, etc. from an inexpensive raw material, in one step and high yield, economically on an industrial scale, by reacting a specific nitrile with 2- aminothiophenol in the presence of an alcohol under pressure. CONSTITUTION:The objective compound of formula II such as 2-(t-butyl)- benzothiazole can be produced by reacting the nitrile of formula R1CN (R1 is alkyl, aryl, aralkyl or heterocyclic group which may have substituent group) with the 2-aminothiophenol of formula I (R2 is same as R1 or H, halogen or N-substituted amino) at a molar ratio of 1:5-5:1 in the presence of an alcohol at 30-150 deg.C for 5-50hr under the pressure of 1,000-9,000kg/cm . The alcohol is a lower alcohol such as methanol, ethanol, etc., and is preferably methanol. The amount of the alcohol is 0.1-10mol per 1mol of the nitrile.