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    Alternative detector configuration and mode of operation of time delay integration particle analyzer
    21.
    发明专利
    Alternative detector configuration and mode of operation of time delay integration particle analyzer 未知

    公开(公告)号：AU9057301A

    公开(公告)日：2002-03-04

    申请号：AU9057301

    申请日：2001-08-24

    Applicant: AMNIS CORP

    Inventor： BASIJI DAVID ,  ORTYN WILLIAM

    IPC: G01N21/64 ,  G01N15/00 ,  G01N15/02 ,  G01N15/14 ,  G01N21/27 ,  G06K9/00 ,  H04N5/232

    Abstract: Light from an object moving through an imaging system is collected, dispersed, and imaged onto a time delay integration (TDI) detector that is inclined relative to an axis of motion of the object, producing a pixilated output signal. In one embodiment, the movement of the image object over the TDI detector is asynchronous with the movement of the output signal producing an output signal that is a composite of the image of the object at varying focal point along the focal plane. In another embodiment, light from the object is periodically incident on the inclined TDI detector, producing a plurality of spaced apart images and corresponding output signals that propagate across the TDI detector. The inclined plane enables images of FISH probes or other components within an object to be produced at different focal points, so that the 3D spatial relationship between the FISH probes or components can be resolved.

    Measuring the velocity of small moving objects such as cells
    22.
    发明专利
    Measuring the velocity of small moving objects such as cells 未知

    公开(公告)号：AU9056801A

    公开(公告)日：2002-03-04

    申请号：AU9056801

    申请日：2001-08-24

    Applicant: AMNIS CORP

    Inventor： BASIJI DAVID ,  ORTYN WILLIAM

    IPC: G01P3/36 ,  G01N15/10 ,  G01N15/14 ,  G01N33/48 ,  G01N33/483 ,  G01P5/26 ,  G02B27/00 ,  G06T7/20 ,  G06K9/00

    Abstract: Frequency domain velocity measurements and time domain velocity measurements are made using light from cells or other objects. An optical grating is used to modulate the light from an object so that it has a frequency proportional to the velocity of the object. Depending upon the embodiment, the pitch of the optical grating is uniform or varying. The modulated light is detected, producing an analog signal that is then digitally sampled. Time domain signal processing techniques are used to determine the velocity of the object from the digital samples. Preferably, the velocity measured is applied in determining a timing signal employed for synchronization of an image of the object and an detector signal in an optical analysis system that uses a time delay integration (TDI) detector to determine characteristics of the object in response to light from the object.

    BLOOD ANALYSIS USING A FLOW IMAGING CYTOMETER
    25.
    发明申请
    BLOOD ANALYSIS USING A FLOW IMAGING CYTOMETER 审中-公开
    使用流量成像测量仪进行血液分析

    公开(公告)号：WO2006083969A3

    公开(公告)日：2008-06-26

    申请号：PCT/US2006003573

    申请日：2006-02-01

    Applicant: AMNIS CORP ,  ORTYN WILLIAM ,  BASIJI DAVID ,  GEORGE THADDEOUS ,  MORRISSEY PHILIP ,  HALL BRIAN ,  PERRY DAVID ,  ZIMMERMAN CATHLEEN

    Inventor： ORTYN WILLIAM ,  BASIJI DAVID ,  GEORGE THADDEOUS ,  MORRISSEY PHILIP ,  HALL BRIAN ,  PERRY DAVID ,  ZIMMERMAN CATHLEEN

    IPC: G06K9/00

    CPC classification number: G06K9/00127 ,  G01N15/147 ,  G01N15/1475 ,  G01N2015/1497

    Abstract: Multimodal/multispectral images of a population of cells are simultaneously collected (402). Photometric and/or morphometric features identifiable in the images (404) are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation (408). Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected.

    Abstract translation: 同时收集细胞群的多峰/多光谱图像（402）。 图像（404）中可识别的光度和/或形态测量特征用于将细胞群分离成多个亚群体。 当细胞群体包括患病细胞和健康细胞时，图像可被分成健康亚群和患病亚群（408）。 在细胞群不包括患病细胞的情况下，不具有疾病状况的患者中不同细胞类型的一种或多种比例可以与具有疾病状况的患者中的相应比例进行比较，从而能够检测疾病状况。 例如，血细胞可以基于它们的图像分离成不同类型，并且可以容易地检测淋巴细胞数量的增加，这是与慢性淋巴细胞性白血病相关的现象。

    AUTO FOCUS FOR A FLOW IMAGING SYSTEM
    26.
    发明申请
    AUTO FOCUS FOR A FLOW IMAGING SYSTEM 审中-公开
    自动聚焦流动成像系统

    公开(公告)号：WO2004092781A3

    公开(公告)日：2005-05-06

    申请号：PCT/US2004011030

    申请日：2004-04-09

    Applicant: AMNIS CORP ,  ORTYN WILLIAM ,  SEO MICHAEL ,  BASIJI DAVID ,  FROST KEITH ,  PERRY DAVID

    Inventor： ORTYN WILLIAM ,  SEO MICHAEL ,  BASIJI DAVID ,  FROST KEITH ,  PERRY DAVID

    IPC: G01N15/14 ,  G02B27/40

    CPC classification number: G01N15/147 ,  G01N2015/1075 ,  G01N2015/1452

    Abstract: A pair of optical gratings (126, 134) are used to modulate light from an object (102), and the modulated light from either optical is used to determine the velocity of the object. Each optical grating is offset from a reference focal point by the same distance, one grating being offset in a positive direction, the other in a negative direction. Signals produced in response to the modulated light can be processed to determine a direction in which a primary collection lens (110) should be moved in order to improve a focus of the imaging system on the object. The lens is moved incrementally in the direction so determined, and the process is repeated until an optimal focus is achieved. In a preferred embodiment, the signals are weighted, so that the optical grating disposed closest to the optimal focus position contributes the most to velocity detection.

    Abstract translation: 一对光栅（126,134）用于调制来自物体（102）的光，并且来自任一光学的调制光用于确定物体的速度。 每个光栅从参考焦点偏移相同的距离，一个光栅在正方向上偏移，另一个光栅在负方向上偏移。 可以处理响应于调制光产生的信号以确定主收集透镜（110）应该移动的方向，以便改善成像系统对物体的焦点。 透镜在如此确定的方向上逐渐移动，并重复该过程，直到达到最佳聚焦。 在优选实施例中，对信号进行加权，使得最靠近最佳聚焦位置布置的光栅最有助于速度检测。

    ALTERNATIVE DETECTOR CONFIGURATION AND MODE OF OPERATION OF A TIME DELAY INTEGRATION PARTICLE ANALYZER
    28.
    发明申请
    ALTERNATIVE DETECTOR CONFIGURATION AND MODE OF OPERATION OF A TIME DELAY INTEGRATION PARTICLE ANALYZER 审中-公开
    替代检测器配置和时间延迟整合分析仪的操作模式

    公开(公告)号：WO0217622A9

    公开(公告)日：2003-10-09

    申请号：PCT/US0126562

    申请日：2001-08-24

    Applicant: AMNIS CORP

    Inventor： BASIJI DAVID ,  ORTYN WILLIAM

    IPC: G01N21/64 ,  G01N15/00 ,  G01N15/02 ,  G01N15/14 ,  G01N21/27 ,  G06K9/00 ,  H04N5/232

    CPC classification number: G06K9/00127 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0232 ,  G01J3/14 ,  G01J3/2823 ,  G01J3/2889 ,  G01N15/14 ,  G01N21/6458 ,  G01N2015/1497

    Abstract: Light from an object (152) moving through an imaging system (154) is collected, dispersed, and imaged onto a time delay integration (TDI) detector (148) that is inclined relative to an axis of motion of the object, producing a pixilated output signal. In one embodiment, the movement of the image object over the TDI detector (148) is asynchronous with the movement of the output signal producing an output signal that is a composite of the image of the object at varying focal point along the focal plane. In another embodiment, light from the object is periodically incident on the inclined TDI, producing a plurality of spaced apart images and corresponding output signals that propagate across the TDI detector (148). The inclined plane enables images of FISH probes or other components within an object to be produced at different focal point, so that the 3D spatial relationship between the FISH probes or components can be resolved.

    Abstract translation: 来自移动通过成像系统（154）的物体（152）的光被收集，分散和成像到相对于物体的运动轴线倾斜的时间延迟积分（TDI）检测器（148），产生像素化 输出信号。 在一个实施例中，图像对象在TDI检测器（148）上的移动与产生输出信号的输出信号的移动是异步的，该输出信号是沿着焦平面的变化焦点处的物体的图像的复合。 在另一个实施例中，来自物体的光周期性地入射到倾斜TDI上，产生多个间隔开的图像和跨越TDI检测器（148）传播的对应的输出信号。 倾斜平面使得可以在不同焦点处产生物体内的FISH探针或其他部件的图像，从而可以解决FISH探针或部件之间的3D空间关系。

    METHOD AND APPARATUS FOR LABELING AND ANALYZING CELLULAR COMPONENTS
    29.
    发明申请
    METHOD AND APPARATUS FOR LABELING AND ANALYZING CELLULAR COMPONENTS 审中-公开
    标签和分析细胞成分的方法和装置

    公开(公告)号：WO02100157A8

    公开(公告)日：2003-05-15

    申请号：PCT/US0205557

    申请日：2002-02-21

    Applicant: AMNIS CORP

    Inventor： ORTYN WILLIAM ,  BASIJI DAVID

    IPC: C12Q1/68 ,  G01N27/447 ,  C07H21/04 ,  C12M1/34

    CPC classification number: G01N27/44726 ,  C12Q1/6841 ,  G01J3/2803 ,  G01J3/36 ,  G01J3/4406 ,  G01N15/147 ,  G01N15/1475 ,  G01N21/6456 ,  G01N2015/1472 ,  G01N2021/6421 ,  G01N2021/6441 ,  C12Q2565/102 ,  C12Q2537/143

    Abstract: A labeling method that labels an object or specific features of an object with labeled probes that provide a multiplexed signal that can be analyzed by spectral decomposition. This binary and higher encoding scheme can be employed to label components of biological cells. In each encoding scheme, labeled probes that selectively bind to a specific feature are required. The labeled probes include a binding element that binds to the feature, and at least one signaling component that generates a detectable signal, preferably a spectral signature. In one embodiment, adding multiple fluorescent dye molecules to each binding element provides the multiplexed signal. In another embodiment, adding only one signal compound to each binding element provides the multiplexed signal, such that some of the binding elements have a different signal compound added. The different signal compounds provide the multiplexed signal.

    Abstract translation: 用标记的探针标记物体的对象或特定特征的标签方法，该探针提供可通过光谱分解分析的复用信号。 该二进制和更高编码方案可用于标记生物细胞的组分。 在每个编码方案中，需要选择性地绑定到特定特征的标记探针。 标记的探针包括结合特征的结合元件和产生可检测信号，优选光谱特征的至少一个信号分量。 在一个实施方案中，向每个结合元件添加多个荧光染料分子提供复用的信号。 在另一个实施方案中，向每个结合元件添加一个信号化合物提供复用的信号，使得一些结合元件具有不同的信号化合物。 不同的信号化合物提供复用的信号。

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