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    METHOD AND APPARATUS FOR THREE-DIMENSIONAL RECONSTRUCTION OF CORONARY VESSELS FROM ANGIOGRAPHIC IMAGES
    22.
    发明申请
    METHOD AND APPARATUS FOR THREE-DIMENSIONAL RECONSTRUCTION OF CORONARY VESSELS FROM ANGIOGRAPHIC IMAGES 审中-公开
    从血管成像三维重建冠状血管的方法和装置

    公开(公告)号：WO1997049065A1

    公开(公告)日：1997-12-24

    申请号：PCT/US1997010194

    申请日：1997-06-17

    Applicant: ARCH DEVELOPMENT CORPORATION

    Inventor： ARCH DEVELOPMENT CORPORATION ,  CHEN, Shiuh-Yung, James ,  CARROLL, John, D. ,  METZ, Charles, E. ,  HOFFMANN, Kenneth, R.

    IPC: G06T11/00

    CPC classification number: G06T11/006 ,  G06T2211/404

    Abstract: A method for in-room computer reconstruction of a three-dimensional (3-D) coronary arterial tree from routine biplane angiograms acquired at arbitrary angles and without using calibration objects. The method includes eight major steps: (1) acquiring biplane projection images of the coronary structure, (2) detecting, segmenting and identifying vessel centerlines and constructing a vessel hierarchy representation, (3) calculating bifurcation points and measuring vessel diameters in coronary angiograms if biplane imaging geometry data is not available, (4) determining biplane imaging parameters in terms of a rotation matrix R and a unit translation vector t based on the identified bifurcation points, (5) retrieving imaging parameters if biplane imaging geometry data is already known, (6) establishing the centerline correspondences of the two-dimensional arterial representations, (7) calculating and recovering the 3-D coronary arterial tree based on the calculated biplane imaging parameters, correspondences of vessel centerlines, and vessel diameters, and (8) rendering the reconstructed 3-D coronary tree and estimating an optimal view of the vasculature to minimize vessel overlap and vessel foreshortening.

    Abstract translation: 一种三维（3-D）冠状动脉树的室内计算机重构方法，用于从任意角度采集的常规双平面血管造影图像，而不使用校准对象。 该方法包括八个主要步骤：（1）获取冠状结构的双平面投影图像，（2）检测，分割和识别血管中心线并构建血管层级表示，（3）计算冠状动脉造影图中的分叉点和测量血管直径，如果 双平面成像几何数据不可用，（4）基于所识别的分叉点来确定旋转矩阵R和单位平移向量t 0的双平面成像参数，（5）如果双平面 成像几何数据已经是已知的，（6）建立二维动脉表现的中心线对应关系，（7）基于计算的双平面成像参数，血管中心线和血管的对应性计算和恢复3-D冠状动脉树 直径，和（8）渲染重建的3-D冠状动脉树并估计脉管系统的最佳视图以最小化血管壁 rlap和血管缩短。

    ISOLATION OF apo(a), COMPOSITIONS, AND METHODS OF USE
    23.
    发明申请
    ISOLATION OF apo(a), COMPOSITIONS, AND METHODS OF USE 审中-公开
    apo（a），组合物和使用方法的分离

    公开(公告)号：WO1997017371A1

    公开(公告)日：1997-05-15

    申请号：PCT/US1996018136

    申请日：1996-11-08

    Applicant: ARCH DEVELOPMENT CORPORATION

    Inventor： ARCH DEVELOPMENT CORPORATION ,  SCANU, Angelo, M. ,  EDELSTEIN, Celina

    IPC: C07K14/775

    CPC classification number: C07K14/775 ,  A61K38/00 ,  C07K16/18

    Abstract: Disclosed are novel compositions comprising purification of active apolipoprotein (a), apo(a), derived from Lp(a). Also disclosed are methods for determining elastase activity and methods for screening for inhibitors of elastase activity. Methods are also disclosed for purifying, quantitating, and reconstituting active lipoprotein(a), Lp(a).

    Abstract translation: 公开了包含纯化源自Lp（a）的活性载脂蛋白（a），载脂蛋白（a））的新型组合物。 还公开了用于测定弹性蛋白酶活性的方法和用于筛选弹性蛋白酶活性抑制剂的方法。 还公开了纯化，定量和重构活性脂蛋白（a），Lp（a）的方法。

    COMPUTERIZED DETECTION OF MASSES AND PARENCHYMAL DISTORTIONS
    26.
    发明申请
    COMPUTERIZED DETECTION OF MASSES AND PARENCHYMAL DISTORTIONS 审中-公开
    计算机检测质量和附件失效

    公开(公告)号：WO1996025879A1

    公开(公告)日：1996-08-29

    申请号：PCT/US1996002065

    申请日：1996-02-23

    Applicant: ARCH DEVELOPMENT CORPORATION

    Inventor： ARCH DEVELOPMENT CORPORATION ,  GIGER, Maryellen, L. ,  ZHANG, Ming ,  LU, Ping

    IPC: A61B06/00

    CPC classification number: G06T7/0012 ,  G06T7/11 ,  G06T2207/10116 ,  G06T2207/20061 ,  G06T2207/20132 ,  G06T2207/30068 ,  G06T2207/30096

    Abstract: A method and system for automated detection of lesions such as masses and/or parenchymal distortions in medical images such as mammograms. Dense regions and subcutaneous fat regions (102) within a mammogram (100) are segmented (101). A background correction may be performed within the dense regions. Hough spectrum within ROIs (104) placed in the breast region of a mammogram (100) are calculated and thresholded (106) using the intensity value eta in order to increase sensitivity and reduce the number of false-positive detections. Lesions are detected based on the thresholded Hough spectra. The thresholded Hough spectra are also used to differentiate between benign and malignant masses.

    Abstract translation: 用于自动检测诸如乳房X线照相术的医学图像中的质量和/或实质变形的病变的方法和系统。 乳房X线照片（100）内的密集区域和皮下脂肪区域（102）被分割（101）。 可以在密集区域内进行背景校正。 计算放置在乳房X线照片（100）的乳房区域内的ROI（104）内的霍夫谱，并使用强度值eta阈值化（106），以增加灵敏度并减少假阳性检测的数量。 基于阈值霍夫光谱检测病变。 阈值霍夫光谱也用于区分良性和恶性肿块。

    AUTOMATED METHOD AND SYSTEM FOR THE ALIGNMENT AND CORRELATION OF IMAGES FROM TWO DIFFERENT MODALITIES
    27.
    发明申请
    AUTOMATED METHOD AND SYSTEM FOR THE ALIGNMENT AND CORRELATION OF IMAGES FROM TWO DIFFERENT MODALITIES 审中-公开
    用于两种不同模式的图像对齐和相关的自动化方法和系统

    公开(公告)号：WO1995015537A1

    公开(公告)日：1995-06-08

    申请号：PCT/US1994013285

    申请日：1994-11-30

    Applicant: ARCH DEVELOPMENT CORPORATION

    Inventor： ARCH DEVELOPMENT CORPORATION ,  GIGER, Maryellen, L. ,  CHEN, Chin-Tu ,  ARMATO, Samuel ,  DOI, Kunio

    IPC: G06K09/32

    CPC classification number: G06T7/0012 ,  G06T3/0075 ,  G06T7/12 ,  G06T7/155 ,  G06T7/66 ,  G06T2207/10116 ,  G06T2207/30061

    Abstract: A method and system for computerized registration of radionuclide images with radiographic images, including generating image data from radiographic and radionuclide images of the thorax (10, 12). Techniques include contouring the lung regions in each type of chest image (15, 16), scaling (17) and registration (19) of the contours based on location of lung apices, and superimposition (18) after appropriate shifting of the images. Specific applications are given for the automated registration of radionuclide lung scans with chest radiographs. The method in the example given yields a system that spatially registers and correlates digitized chest radiographs with V/Q scans in order to correlate V/Q functional information with the greater structural detail of chest radiographs.

    Abstract translation: 一种用放射性图像计算机化注射放射性核素图像的方法和系统，包括从胸部放射照相和放射性核素图像生成图像数据（10,12）。 技术包括根据肺顶点的位置在每种类型的胸部图像（15,16），轮廓的缩放（17）和对准（19）中轮廓化肺部区域，以及在适当移动图像之后叠加（18）。 给出了用于放射性核素肺扫描自动注册胸部X光照片的具体应用。 在给出的示例中的方法产生一个系统，其将数字化胸部X光片与V / Q扫描空间寄存和相关联，以便将V / Q功能信息与胸部X光片的较大结构细节相关联。

    AUTOMATED METHOD AND SYSTEM FOR THE SEGMENTATION OF MEDICAL IMAGES
    28.
    发明申请
    AUTOMATED METHOD AND SYSTEM FOR THE SEGMENTATION OF MEDICAL IMAGES 审中-公开
    用于分割医学图像的自动化方法和系统

    公开(公告)号：WO1995014966A1

    公开(公告)日：1995-06-01

    申请号：PCT/US1994013281

    申请日：1994-11-29

    Applicant: ARCH DEVELOPMENT CORPORATION

    Inventor： ARCH DEVELOPMENT CORPORATION ,  BICK, Ulrich ,  GIGER, Maryellen, L.

    IPC: A61B6/00 ,  G06T1/00 ,  G06T5/00 ,  G06T5/30 ,  G06T7/00

    CPC classification number: G06K9/342 ,  G06K2209/05 ,  G06T7/0012 ,  G06T7/11 ,  G06T7/12 ,  G06T7/136 ,  G06T7/155 ,  G06T7/187 ,  G06T2207/10116 ,  G06T2207/20036 ,  G06T2207/20041 ,  G06T2207/30068

    Abstract: A method for the automated segmentation of medical images (figures 5, 11, 12 and 20), including generating image data (figure 19) from radiographic images of the breast (figure 5). The method is applicable to breast mammograms including the extraction of the skinline as well as correction for non-uniform exposure conditions, hand radiographs (figure 11), and chest radiographs (figure 12). Techniques for the segmentation include noise filtering (152 of figure 15), local gray value range determination (153), modified global histogram analysis (154), region growing and determination of object contour (155). The method also is applicable to skin detection and analysis of skin thickening in medical images, where image segmentation (164), local optimization of external skinline (166), creation of a gradient image, identification of the internal skinline (167) and then skin thickness determination are carried out.

    Abstract translation: 一种用于医学图像（图5,11,12和20）的自动分割的方法，包括从乳房的放射照相图像生成图像数据（图19）（图5）。 该方法适用于乳房X线照片，包括提取皮肤线，以及矫正不均匀的暴露条件，手持放射照片（图11）和胸部X光片（图12）。 用于分割的技术包括噪声滤波（图15中的152），局部灰度值范围确定（153），修改的全局直方图分析（154），区域增长和对象轮廓的确定（155）。 该方法还适用于医学图像中皮肤增厚的皮肤检测和分析，其中图像分割（164），外部皮肤线局部优化（166），创建梯度图像，识别内部皮肤线（167），然后皮肤 进行厚度测定。

    ALIGNMENT METHOD FOR RADIOGRAPHY AND RADIOGRAPHY APPARATUS INCORPORATING SAME
    29.
    发明申请
    ALIGNMENT METHOD FOR RADIOGRAPHY AND RADIOGRAPHY APPARATUS INCORPORATING SAME 审中-公开
    放射学和放射性装置的对准方法

    公开(公告)号：WO1995014432A1

    公开(公告)日：1995-06-01

    申请号：PCT/US1994013635

    申请日：1994-11-28

    Applicant: ARCH DEVELOPMENT CORPORATION

    Inventor： ARCH DEVELOPMENT CORPORATION ,  MACMAHON, Heber

    IPC: A61B06/08

    CPC classification number: A61B6/587 ,  A61B6/08 ,  G03B42/025

    Abstract: An alignment method and system for aligning an anti-scatter grid with an x-ray source of a radiographic apparatus, to facilitate accurate alignment of the central x-ray beam of the x-ray source of the radiographic apparatus with a focused grid. The present invention uses a first light projector that is substantially fixed relative to the x-ray source, which produces a first alignment image that is substantially fixed relative to the grid. Also included is a second light projector that is substantially fixed relative to the grid, and that produces a second alignment image that is substantially fixed relative to the x-ray source. The first light projector is preferably the collimator light included within the collimator housing of the x-ray apparatus, and the second light projector is preferably a laser light source, that is attachable to a grid cassette holding the grid.

    Abstract translation: 用于将防散射格栅与射线照相设备的x射线源对准的对准方法和系统，以便于放射线照相设备的x射线源的中心X射线束与聚焦网格的精确对准。 本发明使用相对于x射线源基本固定的第一光投射器，其产生相对于栅格基本上固定的第一对准图像。 还包括第二光投射器，其基本上相对于格栅固定，并且产生相对于x射线源基本固定的第二对准图像。 第一光投射器优选地是包括在x射线设备的准直器壳体内的准直器光，并且第二光投射器优选地是可附接到保持格栅的格栅盒的激光源。

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