公开(公告)号：MY161425A

公开(公告)日：2017-04-14

申请号：MYPI2010006174

申请日：2009-06-24

Applicant: ARRAY BIOPHARMA INC

Inventor： BURGESS LAURENCE E ,  CLARK CHRISTOPHER T ,  COOK ADAM ,  CORRETTE CHRISTOPHER P ,  DELISLE ROBERT KIRK ,  DOHERTY GEORGE A ,  HUNT KEVIN W ,  ROMOFF TODD ,  KIM GANGHYEOK

IPC: C07D311/04 ,  A61K31/353 ,  A61P29/00 ,  C07D405/12 ,  C07D407/12

Abstract: COMPOUNDS OF FORMULA (I): IN WHICH A1, A2, W, L, G, R7a, R7b, R8, R9 AND R10 HAVE THE MEANINGS GIVEN IN THE SPECIFICATION, ARE DP2 RECEPTOR MODULATORS USEFUL IN THE TREATMENT OF IMMUNOLOGIC DISEASES.

公开(公告)号：DK2663550T3

公开(公告)日：2017-03-27

申请号：DK12734770

申请日：2012-01-12

Applicant: VENTIRX PHARMACEUTICALS INC ,  ARRAY BIOPHARMA INC

Inventor： BURGESS LAURENCE E ,  YANG HONG WOON ,  HOWBERT JAMES JEFFRY ,  HERSHBERG ROBERT

IPC: C07D223/16 ,  A61K31/55 ,  A61P29/00 ,  A61P35/00 ,  C07D401/04 ,  C07D403/10 ,  C07D413/10 ,  C07D487/04

公开(公告)号：AU2017200937A1

公开(公告)日：2017-03-02

申请号：AU2017200937

申请日：2017-02-10

Applicant: ARRAY BIOPHARMA INC ,  VENTIRX PHARMACEUTICALS INC

Inventor： HOWBERT JAMES JEFFRY ,  DIETSCH GREGORY ,  HERSHBERG ROBERT ,  BURGESS LAURENCE E ,  LYSSIKATOS JOSEPH P ,  NEWHOUSE BRAD ,  YANG HONG WOON

IPC: C07D223/14 ,  A61K31/4025 ,  A61K31/454 ,  A61K31/55 ,  A61P31/00 ,  A61P35/00 ,  C07D401/14 ,  C07D403/10

Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.

公开(公告)号：CA2748099C

公开(公告)日：2017-02-28

申请号：CA2748099

申请日：2009-12-18

Applicant: ARRAY BIOPHARMA INC

Inventor： COOK ADAM ,  HUNT KEVIN W ,  DELISLE ROBERT KIRK ,  ROMOFF TODD ,  CLARK CHRISTOPHER T ,  KIM GANGHYEOK ,  CORRETTE CHRISTOPHER P ,  DOHERTY GEORGE A ,  BURGESS LAURENCE E

IPC: C07D405/12 ,  A61K31/353 ,  A61P29/00 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12

Abstract: Compounds of Formula I: (I) in which A, A', R1, R7a, R7b, R8 and R10 have the meanings given in the specification, are DP2 receptor inhibitors useful in the treatment of useful in the treatment and prevention of immunologic diseases, allergic diseases such as asthma, allergic rhinitis and atopic dermatitis, and other inflammatory diseases mediated by prostaglandin D2 (PGD2). The compounds of Formula I may also be useful in treating diseases or medical conditions involving the Th2 T cell via production of IL-4, IL-5 and/or IL-13.

公开(公告)号：AU2010284241B2

公开(公告)日：2016-11-10

申请号：AU2010284241

申请日：2010-08-18

Applicant: ARRAY BIOPHARMA INC ,  VENTIRX PHARMACEUTICALS INC

Inventor： HOWBERT JAMES JEFFRY ,  DIETSCH GREGORY ,  HERSHBERG ROBERT ,  BURGESS LAURENCE E ,  DOHERTY GEORGE A ,  EARY C TODD ,  GRONEBERG ROBERT D ,  JONES ZACHARY

IPC: C07D403/10 ,  A61K31/4025 ,  A61K31/55 ,  A61P31/00 ,  A61P35/00 ,  C07D223/14 ,  C07D401/14 ,  C07D403/14

Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll- like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.

公开(公告)号：MX2014004473A

公开(公告)日：2015-04-14

申请号：MX2014004473

申请日：2012-10-09

Applicant: ARRAY BIOPHARMA INC

Inventor： ROBINSON JOHN E ,  HACHE BRUNO P ,  MORENO DAVID A ,  BOYS MARK LAURENCE ,  BURGESS LAURENCE E ,  EARY C TODD ,  GRONEBERG ROBERT ,  HARVEY DARREN ,  HICKEN ERIK JAMES ,  KRASER CHRISTOPHER F ,  LAIRD ELLEN ,  MUNSON MARK C ,  REN LI ,  SCHLACHTER STEPHEN T

IPC: C07D487/04 ,  A61K31/519 ,  A61P29/00 ,  A61P37/00

Abstract: Se describen compuestos de Fórmula I; y estereoisómeros y sales farmacéuticamente aceptables de estos, donde R1, R2, R3, R4, R5, R6, X1 y X2 tienen los significados que se proporcionan en la memoria descriptiva, son inhibidores de una o más cinasas JAK y son útiles en el tratamiento de enfermedades autoinmunitarias, enfermedades inflamatorias, rechazo de órganos, tejidos y células transplantadas, así como neoplasias y trastornos hematológicos y sus comorbilidades.

公开(公告)号：HRP20140988T1

公开(公告)日：2014-12-05

申请号：HRP20140988

申请日：2014-10-15

Applicant: ARRAY BIOPHARMA INC

Inventor： BURGESS LAURENCE E ,  CLARK CHRISTOPHER T ,  COOK ADAM ,  CORRETTE CHRISTOPHER P ,  DELISLE ROBERT KIRK ,  DOHERTY GEORGE A ,  HUNT KEVIN W ,  ROMOFF TODD ,  KIM GANGHYEOK

IPC: C07D311/04 ,  A61K31/353 ,  A61P29/00 ,  C07D405/12 ,  C07D407/12

公开(公告)号：DK2307397T3

公开(公告)日：2014-11-03

申请号：DK09770959

申请日：2009-06-24

Applicant: ARRAY BIOPHARMA INC

Inventor： KIM GANGHYEOK ,  BURGESS LAURENCE E ,  CLARK CHRISTOPHER T ,  COOK ADAM ,  CORRETTE CHRISTOPHER P ,  DELISLE ROBERT KIRK ,  DOHERTY GEORGE A ,  HUNT KEVIN W ,  ROMOFF TODD

IPC: C07D311/04 ,  A61K31/353 ,  A61P29/00 ,  C07D405/12 ,  C07D407/12

公开(公告)号：PT2307397E

公开(公告)日：2014-10-29

申请号：PT09770959

申请日：2009-06-24

Applicant: ARRAY BIOPHARMA INC

Inventor： DELISLE ROBERT KIRK ,  BURGESS LAURENCE E ,  CLARK CHRISTOPHER T ,  COOK ADAM ,  CORRETTE CHRISTOPHER P ,  DOHERTY GEORGE A

IPC: C07D311/04 ,  A61K31/353 ,  A61P29/00 ,  C07D405/12 ,  C07D407/12

公开(公告)号：CR20140216A

公开(公告)日：2014-08-21

申请号：CR20140216

申请日：2014-05-09

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  BURGESS LAURENCE E ,  EARY C TODD ,  GRONEBERG ROBERT ,  HACHE BRUNO P ,  HARVEY DARREN ,  HICKEN ERIK JAMES ,  KRASER CHRISTOPHER F ,  LAIRD ELLEN ,  MORENO DAVID A ,  MUNSON MARK C ,  REN LI ,  ROBINSON JOHN E ,  SCHLACHTER STEPHEN T

IPC: C07D487/04 ,  A61K31/519 ,  A61P29/00 ,  A61P37/00

Abstract: Compuestos de Fórmula I: y estereoisómeros y sales y solvatos farmacéuticamente aceptables de estos, donde R1, R2, R3, R4, R5, R6, X1 y X2 tienen los significados que se proporcionan en la memoria descriptiva, son inhibidores de una o más cinasas JAK y s