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1.BIOMARKERS PREDICTIVE OF RESPONSIVENESS TO TREATMENT WITH A CRTh2 INHIBITOR 审中-公开
Title translation: 生物标志物预测用CRTh2抑制剂治疗的反应公开(公告)号:WO2015126750A4
公开(公告)日:2015-10-29
申请号:PCT/US2015015806
申请日:2015-02-13
Applicant: ARRAY BIOPHARMA INC
Inventor: BURGESS LAURENCE E , CHANTRY DAVID HARRY , EBERHARDT CHRISTINE D
IPC: G01N33/497 , G01N33/50 , G01N33/88
CPC classification number: G01N33/84 , A61K31/353 , A61K31/47 , G01N33/564 , G01N2800/122 , G01N2800/52 , A61K2300/00
Abstract: Provided herein is the identification of biomarkers that are predictive of a patient's responsiveness to a therapy comprising treatment with a CRTh2 antagonist, such as ARRY-502. Biomarkers identified include baseline levels of the fraction exhaled nitric oxide and the percentage of eosinophil of the total lymphocyte population in peripheral blood.
Abstract translation: 本文提供了可预测患者对包括用CRTh2拮抗剂如ARRY-502进行治疗的治疗反应性的生物标志物的鉴定。 确定的生物标志物包括呼出一氧化氮的分数的基线水平和外周血中总淋巴细胞群的嗜酸性粒细胞百分比。
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2.SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS 审中-公开
Title translation: 作为类似感受体调节剂的替代苯扎林公开(公告)号:WO2011022509A3
公开(公告)日:2011-06-16
申请号:PCT/US2010045935
申请日:2010-08-18
Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC , HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , DOHERTY GEORGE A , EARY C TODD , GRONEBERG ROBERT D , JONES ZACHARY
Inventor: HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , DOHERTY GEORGE A , EARY C TODD , GRONEBERG ROBERT D , JONES ZACHARY
IPC: C07D403/10 , A61K31/4025 , A61K31/55 , A61P31/00 , A61P35/00 , C07D223/14 , C07D401/14 , C07D403/14
CPC classification number: C07D223/16 , A61K31/4025 , A61K31/55 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/14
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll- like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
Abstract translation: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病,包括癌症,自身免疫性疾病,感染性疾病,炎性疾病,移植物排斥反应和移植物宿主病。
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公开(公告)号:WO0204412A3
公开(公告)日:2002-08-22
申请号:PCT/US0141271
申请日:2001-07-05
Applicant: ARRAY BIOPHARMA INC , BURGESS LAURENCE E , GAUDINO JOHN , GRONEBERG ROBERT D , NORMAN MARK H , RODRIGUEZ MARTHA E , SUN XICHENG , WALLACE ELI M , AMGEN INC
Inventor: BURGESS LAURENCE E , GAUDINO JOHN , GRONEBERG ROBERT D , NORMAN MARK H , RODRIGUEZ MARTHA E , SUN XICHENG , WALLACE ELI M
IPC: A61K31/192 , A61K31/194 , A61K31/196 , A61K31/341 , A61K31/4045 , A61K31/41 , A61K31/4402 , A61P3/10 , A61P7/12 , A61P35/00 , A61P43/00 , C07C237/22 , C07C311/13 , C07C311/19 , C07C311/29 , C07D209/14 , C07D209/16 , C07D213/40 , C07D257/04 , C07D307/52 , A61K31/165 , A61K31/166
CPC classification number: C07D213/40 , C07C237/22 , C07C311/13 , C07C311/19 , C07C311/29 , C07D209/14 , C07D209/16 , C07D257/04 , C07D307/52
Abstract: Disclosed are compounds of the Formula (I), and pharmaceutically acceptable salts and prodrugs thereof, wherein A, B, R , R , R , R and R are as defined in the specification. Such compounds are tyrosine phosphatase inhibitors and useful in the treatment or prevention of Type II Diabetes Mellitus. Also encompassed by the invention are formulations comprising the noted compounds, processes for preparing such compounds, a method for treating or preventing Type II Diabetes Mellitus.
Abstract translation: 公开了式(I)化合物及其药学上可接受的盐和前药,其中A,B,R 1,R 2,R 3,R 4和R 5如上所定义 在规范中。 这些化合物是酪氨酸磷酸酶抑制剂,可用于治疗或预防II型糖尿病。 本发明还包括包含所述化合物的制剂,制备这些化合物的方法,治疗或预防II型糖尿病的方法。
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4.SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS 审中-公开
Title translation: 作为类似感受体调节剂的替代苯扎林公开(公告)号:WO2011022508A2
公开(公告)日:2011-02-24
申请号:PCT/US2010045934
申请日:2010-08-18
Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC , HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , LYSSIKATOS JOSEPH P , NEWHOUSE BRAD , YANG HONG WOON
Inventor: HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , LYSSIKATOS JOSEPH P , NEWHOUSE BRAD , YANG HONG WOON
IPC: C07D401/14 , A61K31/4025 , A61K31/454 , A61K31/55 , A61P31/00 , A61P35/00 , C07D223/14 , C07D403/10
CPC classification number: A61K31/55 , C07D223/14 , C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/04 , C07D405/10
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
Abstract translation: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病,包括癌症,自身免疫性疾病,感染性疾病,炎性疾病,移植物排斥反应和移植物宿主病。
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5.CYCLOSPORIN ANALOGS FOR THE TREATMENT OF IMMUNOREGULATORY DISORDERS AND RESPIRATORY DISEASES 审中-公开
Title translation: 用于治疗免疫缺陷性疾病和呼吸道疾病的环磷酰胺类似物公开(公告)号:WO2006023452A2
公开(公告)日:2006-03-02
申请号:PCT/US2005029003
申请日:2005-08-15
Applicant: ARRAY BIOPHARMA INC , HUNT KEVIN W , BURGESS LAURENCE E
Inventor: HUNT KEVIN W , BURGESS LAURENCE E
CPC classification number: A61K38/13 , A61K47/54 , A61K47/545 , C07K7/645
Abstract: Provided are novel cyclosporin analogs, methods for their production, and their use for treating immunoregulatory and respiratory diseases, disorders, and conditions.
Abstract translation: 提供新的环孢菌素类似物,其生产方法及其用于治疗免疫调节和呼吸系统疾病,病症和病症的用途。
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公开(公告)号:EP2467377A4
公开(公告)日:2013-01-02
申请号:EP10810563
申请日:2010-08-18
Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC
Inventor: HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , LYSSIKATOS JOSEPH P , NEWHOUSE BRAD , YANG HONG WOON
IPC: C07D401/14 , A61K31/4025 , A61K31/454 , A61K31/55 , A61P31/00 , A61P35/00 , C07D223/14 , C07D403/10
CPC classification number: A61K31/55 , C07D223/14 , C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/04 , C07D405/10
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公开(公告)号:EP2663555A4
公开(公告)日:2014-07-16
申请号:EP12733896
申请日:2012-01-12
Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC
Inventor: HOWBERT JAMES JEFFRY , HERSHBERG ROBERT , BURGESS LAURENCE E , DOHERTY GEORGE A , EARY CHARLES TODD , GRONEBERG ROBERT D , JONES ZACHARY , LYSSIKATOS JOSEPH P , YANG HONG WOON
IPC: A61K31/55 , A61P37/00 , C07D223/16 , C07D243/14 , C07D401/12 , C07D487/04
CPC classification number: C07D223/16 , C07D243/14 , C07D401/12 , C07D487/04
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8.
公开(公告)号:EP2467380A4
公开(公告)日:2013-01-02
申请号:EP10810564
申请日:2010-08-18
Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC
Inventor: HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , DOHERTY GEORGE A , EARY C TODD , GRONEBERG ROBERT D , JONES ZACHARY
IPC: C07D403/10 , A61K31/4025 , A61K31/55 , A61P31/00 , A61P35/00 , C07D223/14 , C07D401/14 , C07D403/14
CPC classification number: C07D223/16 , A61K31/4025 , A61K31/55 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/14
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公开(公告)号:AU2018369759B2
公开(公告)日:2022-11-24
申请号:AU2018369759
申请日:2018-11-14
Applicant: ARRAY BIOPHARMA INC , MIRATI THERAPEUTICS INC
Inventor: BLAKE JAMES F , BURGESS LAURENCE E , CHICARELLI MARK JOSEPH , CHRISTENSEN JAMES GAIL , COOK ADAM , FELL JAY BRADFORD , FISCHER JOHN P , MARX MATTHEW ARNOLD , MEJIA MACEDONIO J , SAVECHENKOV PAVEL , VIGERS GUY P A , SMITH CHRISTOPHER RONALD , RODRIGUEZ MARTHA E
IPC: C07D401/06 , C07D401/14
Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
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公开(公告)号:PL3227297T3
公开(公告)日:2021-10-25
申请号:PL15819933
申请日:2015-12-04
Applicant: ARRAY BIOPHARMA INC , CELGENE CORP
Inventor: ALLEN SHELLEY , BOYS MARK LAURENCE , CHICARELLI MARK J , FELL JAY BRADFORD , FISCHER JOHN P , GAUDINO JOHN , HICKEN ERIK JAMES , HINKLIN RONALD JAY , KRASER CHRISTOPHER F , LAIRD ELLEN , ROBINSON JOHN E , TANG TONY P , BURGESS LAURENCE E , RIEGER ROBERT ANDREW , PHENEGER JED , SATOH YOSHITAKA , LEFTHERIS KATERINA , RAHEJA RAJ K , BENNETT BRYDON L
IPC: C07D487/04 , A61K31/4985 , A61P29/00 , A61P37/00
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