公开(公告)号：EP2209778B1

公开(公告)日：2012-08-29

申请号：EP08834504.6

申请日：2008-09-15

Applicant: Array Biopharma, Inc.

Inventor： AICHER, Thomas Daniel ,  BOYD, Steven Armen ,  CHICARELLI, Mark Joseph ,  CONDROSKI, Kevin Ronald ,  FELL, Jay Bradford ,  FISCHER, John P. ,  GUNAWARDANA, Indrani W. ,  HINKLIN, Ronald Jay ,  SINGH, Ajay ,  TURNER, Timothy M. ,  WALLACE, Eli M.

IPC: C07D417/12 ,  C07D417/14 ,  A61K31/433 ,  A61P3/10

CPC classification number: C07D401/14 ,  C07D213/75 ,  C07D401/12 ,  C07D417/12 ,  C07D417/14

公开(公告)号：EP2250155A1

公开(公告)日：2010-11-17

申请号：EP09701043.3

申请日：2009-01-09

Applicant: Array Biopharma, Inc. ,  Genentech, Inc.

Inventor： BANKA, Anna ,  BENCSIK, Josef R. ,  BLAKE, James F. ,  HENTEMANN, Martin F. ,  KALLAN, Nicholas C. ,  LIANG, Jun ,  MITCHELL, Ian S. ,  SCHLACHTER, Stephen T. ,  WALLACE, Eli M. ,  XU, Rui ,  TANG, Tony, P.

IPC: C07D239/70 ,  A61K31/517 ,  A61P35/00 ,  C07D401/04 ,  C07D401/10 ,  C07D409/04 ,  C07D417/04 ,  C07D487/04

CPC classification number: C07D401/10 ,  C07D211/08 ,  C07D211/46 ,  C07D239/70 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D409/04 ,  C07D417/04 ,  C07D417/10 ,  C07D487/04

Abstract: Compounds of Formula I are useful for inhibiting AKT protein kinases. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. Formula (I).