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    Prepn. of E-oxime ether(s) of phenyl-glyoxylic acid ester(s)
    21.
    发明专利
    Prepn. of E-oxime ether(s) of phenyl-glyoxylic acid ester(s) 未知

    公开(公告)号：DE4042283A1

    公开(公告)日：1992-07-02

    申请号：DE4042283

    申请日：1990-12-31

    Applicant: BASF AG

    Inventor： WOLF BERND DR ,  BENOIT REMY DR ,  SAUTER HUBERT DR ,  WINGERT HORST DR ,  HEPP MICHAEL DR ,  KUEKENHOEHNER THOMAS DR ,  GRAMMENOS WASSILIOS DR

    IPC: C07C51/367 ,  C07C65/24 ,  C07C69/738 ,  C07C235/34 ,  C07C249/08 ,  C07C251/48 ,  C07C253/14 ,  C07C255/17 ,  C07C317/24

    Abstract: Prepn. of E-oxime-ethers of phenylglyoxylic acid esters of formula (I) comprises (a) reacting a phenol Xm-Ph-PH in a base in the presence of a solvent to give a phenolate; (b) mixing with a lactone of formula (III); (c) distilling off solvent and reacting the mixt. at 50-250 deg.C in the melt; (d) washing with water and acid to give a 2-phenoxymethylbenzoic acid of formula (IV); Q = OH); (e) treating with phosgene or SOCl2 to give the 2-phenoxymethylbenzoyl chloride (IV; Q = Cl); (f) reacting with alkali(ne earth)metal cyanide opt. in the presence of prussic acid; (g) treating the 2-phenoxymethylbenzoyl cyanide (IV; Q = CN) with MeOH in the presence of acid to give (VIIb); (h) opt. splitting under acidic conditions to give (IV; Q = C(O)NHR) or (i) treating (IV; Q=R) with dimethyl sulphoxide in the presence of a base to give a beta ketosulphoxide (IV; Q = CH2SOCH3) and treating with a halogenating agent, and MeOH in acid to give (IV; Q = C(O)OMe); (k) reacting (IV; Q = C(O)OMe) and/or (VIIb) with O-methylhydroxylamine or its acid addn. salt to give (I). Q = R1CH2SOMe, OH, Cl, CN or C(O)NNR; X, Y = halo, 1-4C alkyl, 1-4C alkoxy or CF3; m = 0-4; n = 0-3; R = 1-4C alkyl.

    Prepn. of E-oxime ether(s) of phenyl-glyoxylic acid ester(s)
    22.
    发明专利
    Prepn. of E-oxime ether(s) of phenyl-glyoxylic acid ester(s) 未知

    公开(公告)号：DE4042273A1

    公开(公告)日：1992-07-02

    申请号：DE4042273

    申请日：1990-12-31

    Applicant: BASF AG

    Inventor： WINGERT HORST DR ,  WOLF BERND DR ,  BENOIT REMY DR ,  SAUTER HUBERT DR ,  HEPP MICHAEL DR ,  GRAMMENOS WASSILIOS DR ,  KUEKENHOEHNER THOMAS DR

    IPC: C07C51/367 ,  C07C65/24 ,  C07C69/738 ,  C07C235/34 ,  C07C249/08 ,  C07C251/48 ,  C07C253/14 ,  C07C255/17 ,  C07C317/24

    Abstract: Prepn. of E-oxime-ethers of phenylglyoxylic acid esters of formula (I) comprises (a) reacting a phenol Xm-Ph-PH in a base in the presence of a solvent to give a phenolate; (b) mixing with a lactone of formula (III); (c) distilling off solvent and reacting the mixt. at 50-250 deg.C in the melt; (d) washing with water and acid to give a 2-phenoxymethylbenzoic acid of formula (IV); Q = OH); (e) treating with phosgene or SOCl2 to give the 2-phenoxymethylbenzoyl chloride (IV; Q = Cl); (f) reacting with alkali(ne earth)metal cyanide opt. in the presence of prussic acid; (g) treating the 2-phenoxymethylbenzoyl cyanide (IV; Q = CN) with MeOH in the presence of acid to give (VIIb); (h) opt. splitting under acidic conditions to give (IV; Q = C(O)NHR) or (i) treating (IV; Q=R) with dimethyl sulphoxide in the presence of a base to give a beta ketosulphoxide (IV; Q = CH2SOCH3) and treating with a halogenating agent, and MeOH in acid to give (IV; Q = C(O)OMe); (k) reacting (IV; Q = C(O)OMe) and/or (VIIb) with O-methylhydroxylamine or its acid addn. salt to give (I). Q = R1CH2SOMe, OH, Cl, CN or C(O)NNR; X, Y = halo, 1-4C alkyl, 1-4C alkoxy or CF3; m = 0-4; n = 0-3; R = 1-4C alkyl.

    O-iminooxymethylbenzoic acids, their preparation and use as intermediates
    24.
    发明专利
    O-iminooxymethylbenzoic acids, their preparation and use as intermediates 未知

    公开(公告)号：GR3024663T3

    公开(公告)日：1997-12-31

    申请号：GR970402305

    申请日：1997-09-09

    Applicant: BASF AG

    Inventor： BENOIT REMY DR ,  SAUTER HUBERT DR

    IPC: C07C253/30 ,  C07C249/12 ,  C07C251/60 ,  C07C255/17 ,  C07C255/57 ,  C07C255/61 ,  C07C259/04 ,  C07C259/12 ,  C07C259/14 ,  C07C259/18 ,  C07C317/24 ,  C07C323/47 ,  C07C323/63 ,  C07D209/14 ,  C07D209/48 ,  C07D213/53 ,  C07D213/57 ,  C07D239/26 ,  C07D277/20 ,  C07D277/38 ,  C07D333/24 ,  C07D333/36

    Abstract: Process for the preparation of an o-iminooxymethylbenzoic acid of the general formula I in which m denotes an integer from 0 to 3, X denotes alkyl, alkoxy, nitro, cyano, or halogen, R1 and R2 denote hydrogen, cyano, hydroxyl, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, alkoxy, alkylthio, benzylthio, benzylamino, alkylcarbonyl, optionally substituted phenylcarbonyl, optionally substituted benzylcarbonyl, alkoxycarbonyl, optionally substituted phenoxycarbonyl, optionally substituted benzyloxycarbonyl, optionally substituted aryl, optionally substituted aryloxy, optionally substituted arylthio, optionally substituted arylalkyl, optionally substituted arylalkenyl, optionally substituted aryloxyalkyl, optionally substituted arylthioalkyl, optionally substituted hetaryl, optionally substituted hetaryloxy, optionally substituted hetarylthio, optionally substituted heteroarylalkyl, optionally substituted hetarylalkenyl, optionally substituted hetaryloxyalkyl, hetarylthioalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclyloxy, or denote N(R )2, where R denotes H, alkyl or phenyl, or denote -CO-N(R )2, where R denotes H, alkyl or phenyl, or R and R together with the C atom which they substitute can form a carbo- or heterocyclic ring, or R or R denotes halogen or the group denotes the radical where n denotes the integers 1 to 4 and the radicals R denote H, halogen, cyano, nitro; alkyl, alkoxy, aryl, aryloxy, benzyloxy, hetaryl and hetaryloxy, by reacting an oxime of the general formula II in which R1 and R2 have the abovementioned meanings, with a lactone of the general formula III in which X and m have the abovementioned meaning, if appropriate in the presence of a base or of a diluent, and o-iminooxymethylbenzoic acids of the abovementioned formula.

    29.
    发明专利
    未知

    公开(公告)号：ES2104449T3

    公开(公告)日：1997-10-01

    申请号：ES95110519

    申请日：1992-01-17

    Applicant: BASF AG

    Inventor： BENOIT REMY DR ,  SAUTER HUBERT DR ,  KIRSTGEN REINHARD DR ,  LORENZ GISELA DR ,  AMMERMANN EBERHARD DR

    IPC: A01N35/10 ,  A01N37/12 ,  A01N37/34 ,  A01N37/50 ,  A01N43/10 ,  A01N53/10 ,  C07C251/48 ,  C07C251/50 ,  C07C251/58 ,  C07C251/60 ,  C07C251/80 ,  C07C255/61 ,  C07C255/62 ,  C07D239/52

    Abstract: alpha -Imino oxime cpds, described as oxime ethers, of formula (I) are new: R = CR2R3R4 or opt. substd. 3-8C cycloalkyl, 2-8C alkenyl, 2-8C alkynyl, phenyl or heteroaryl; R1 = H or 1-8C alkyl; R2 = H, 1-8C alkyl, aralkyl, heteroarylalkyl, alkoxyalkyl, aryloxyalkyl, aryl or heteroaryl; R3 = H, Me, CN, COOH or 2-9C alkoxycarbonyl; R4 = a gp. as defined for R2; or CR2R3 is a 5- to 8-membered lactone ring or CR2R4 is a 3-8C cycloalkane ring; R5 = H, 1-8C alkyl, aralkyl, 3-6C cycloalkyl, OH, 1-4C alkoxy, NH2, 1-4C alkylamino or dialkylamino; Y = a gp. stated to be an opt. substd. 1-8C alkyl, opt. substd. 2-8C alkenyl, 2-8C alkynyl, O, S(O)m (m = 0-2), N substd. by opt. substd. 1-8C alkyl, oxycarbonyl, carbonyloxy, oxycarbonyl (1-8C) alkyl, carbonyloxy (1-8C) alkyl, 2-8C oxyalkyloxy, 2-8C oxyalkenyl, 1-8C alkoxy, 1-4C oxyalkyl, 1-8C thioalkyl, azo, opt. 1-8C alkyl-substd. -carbonylamino, -aminocarbonyl or -aminocarbonyloxy, oxyimino or opt. substd. imino oxyalkyl; Z = (a) 1-18C alkyl, 2-18C alkenyl, 3-18C alkynyl, aryl, aryl (1-10C) alkyl, aryl (2-10C) alkenyl, aryloxy (1-10C) alkyl, (1-4C) alkoxy (1-10C) alkyl, 1-10C haloalkyl, 2-5C alkoxycarbonyl or heteroaryl; (b) aryloxy, aryloxy (1-10C) alkoxy, aryl (1-10C) alkoxy, 1-10C alkoxy or heteroaryloxy when Y is not oxyalkyl, oxyalkyloxy, thialkyl (sic), -O-N=C- (sic), -N=N-, oxycarbonyl, oxycarbonyloxy, O or S; or (c) 1-18C alkylthio or arylthio when Y is not oxyalkyl, oxyalkyloxy, -O-N=C- (sic), -N=N-, oxycarbonyl, oxycarbonyloxy or O, and Z is opt. substd. by halogen, CN, NO2, 1-4C alkyl, 2-4C alkenyl, 1-4C alkoxy, 1-4C haloalkyl, (1-4C) alkoxy (1-4C) alkyl, di(1-4C) alkoxy (1-4C) alkyl, opt. substd. 1-10C alkoxyimino, opt. substd. 2-10C alkenyloxyimino, opt. substd. aralkoxyimino, opt. substd. 2-10C alkanoyl, opt. substd. formyl, 2-4C haloalkenyl, 2-5C alkoxycarbonyl, opt. substd. phenyl, or opt. substd. 5-membered heterocyclyl which contains 1-4 heteroatoms (N, O and/or S) and is opt. fused with an opt. substd. aromatic or heteroaromatic ring; X = H, halogen, NO2 and/or opt. substd. 1-4C alkyl, 1-4C alkoxy and/or 1-4C haloalkyl; m = 1-4.

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