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    4.
    发明专利
    未知

    公开(公告)号：DE4405712A1

    公开(公告)日：1995-08-24

    申请号：DE4405712

    申请日：1994-02-23

    Applicant: BASF AG

    Inventor： BRATZ MATTHIAS DR ,  MEYER NORBERT DR ,  KOENIG HARTMANN DR ,  WALTER HELMUT DR ,  GERBER MATTHIAS DR ,  WESTPHALEN KARL-OTTO DR

    IPC: A01N43/90 ,  C07D471/04 ,  C07D491/147

    Abstract: Naphthyridine derivs. of formula (I) are new: R1 = (a) opt. substd., opt. benzo-fused 5-membered heteroaryl with 1-2 heteroatoms selected from N, S and O; (b) opt. substd. 6-membered heteroaryl contg. 1-2 N atoms; (c) phenyl with 1-4 substits. selected from (i) 1-8C alkyl, 2-8C alkenyl, 2-8C alkynyl, 3-8C cycloalkyl, phenyl, 1-5C alkoxy, 1-5C alkylthio and 5- or 6-membered satd. or aromatic heterocyclyl, all opt mono- to tri-substd., and (ii) OH, OCOR14, NH2, NR15R16, halogen, CN, NO2, COOH, SO2R7, COR8, CYR9 and CR12(VR10)(WR11) (correction; claim reads W11 in place of WR11); (d) phenyl with two adjacent positions substd. by a tri- or tetramethylene gp. (opt. substd. by 1-3 of 1-2C alkyl, 1-2C alkoxy and halogen), the other positions being opt. substd. as in (c); or (e) phenyl ortho-linked to R2 via a chain of 1-4 CH2 gps or 1-3 CH2 gps. and an O atom, where each CH2 gp. in opt. mono- or disubstd. by 1-2C alkyl; R7 = 1-8C alkyl, 3-8C cycloalkyl, 1-8C haloalkyl, 1-5C alkoxy, phenyl, naphthyl, aryl(1-6C)alkyl, heteroaryl, OH, NH2, mono- or di(1-8C alkyl)amino or 5-8C cycloalkylamino; R8 = OH, NH2, mono- or di(1-8C alkyl)amino, 5-8C cycloalkylamino, 1-6C alkylthio or 1-8C alkoxy; R9 = H, 1-8C alkyl, 3-8C cycloalkyl, 1-8C haloalkyl, (1-4C)alkoxy(1-6C)alkyl, 1-8C aminoalkyl, phenyl, aryl(1-6C)alkyl or heteroaryl; R10 and R11 = 1-8C alkyl, 1-6C haloalkyl or (1-4C)alkoxy(1-6C) alkyl, or R10+R11 = di- to tetramethylene opt. substd. by 1-2 of 1-8C alkyl, 1-6C haloalkyl or (1-4C)alkoxy(1-6C)alkyl or by an oxo gp.; R12 = a gp. as defined for R9; R13 = 1-8C alkoxy (sic; disclosure reads alkyl), 2-8C alkenyl, 3-8C cycloalkyl, 1-8C haloalkyl, (1-4C)alkoxy(1-6C) alkyl (claim reads O 1-4C alkoxy-(1-6C) alkyl), 1-8C aminoalkyl, phenyl, aryl(1-6C)alkyl, heteroaryl, OH, opt. substd. 6-10C aryloxy (claim reads 0-...aryloxy), opt. substd. 1-8C alkoxy, NH2, mono- or di(1-8C alkyl)amino, 5-8C cycloalkylamino or opt. substd. 6-10C arylamino; R14 = 1-5C alkyl, opt. substd. phenyl, 1-5C alkoxy, 1-5C haloalkoxy, benzyloxy, NH2, mono- or dialkylamino, or N-bonded 5- or 6-membered satd. heterocyclyl opt. contg. another N or O heteroatom; R15 = H, 1-5C alkyl or opt. substd. phenyl; R16 = H, 1-5C alkyl, opt. substd. phenyl or COR14; or R15+R16 = tetra- or pentamethylene opt mono- or disubstd. by Me and opt. with one CH2 gp. replaced by O; Y = O or NR13 (correction; claim reads NR12); V and W = O or S; R2-R6 = H, 1-8C alkyl, 2-8C alkenyl, 3-8C cycloalkyl, 1-8C haloalkyl, (1-4C)alkoxy(1-6C)alkyl, 1-8C aminoalkyl, opt. substd. phenyl, benzyl, opt. substd. C-bonded 5- or 6-membered heteroaryl, CN, NO2, COOH, sulphonylmethyl (sic), 2-5C alkoxycarbonyl, CONH2, 1-8C alkylcarbamoyl, dialkylcarbamoyl, 1-4C alkanoyl or benzoyl, or R4+R5 or R5_R6 = (CH2)n or form an aromatic ring; n = 1-3; further provisos and exclusions are given.

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