公开(公告)号：ZA9802136B

公开(公告)日：1999-09-13

申请号：ZA9802136

申请日：1998-03-13

Applicant: BASF AG

Inventor： ROMERDAHL CYNTHIA A

IPC: C07D251/30 ,  A61K31/505 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61P35/00 ,  C07D239/60 ,  C07D405/12 ,  C07D409/12 ,  A61K ,  C07C ,  C07D

CPC classification number: A61K31/53 ,  A61K31/505 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519

公开(公告)号：BR9609423A

公开(公告)日：1999-06-29

申请号：BR9609423

申请日：1996-06-03

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  EMLING FRANZ ,  ROMERDAHL CYNTHIA A

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/04 ,  C07K5/103 ,  C07K7/06

Abstract: Novel compounds of the formulaR1R2N-CHX-CO-A-B-D-(E)s-(F)t-(G)U-KIin which R1, R2, A, B, D, E, F, G, K, X, s, t, and u have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.

公开(公告)号：HU9801910A2

公开(公告)日：1999-01-28

申请号：HU9801910

申请日：1996-06-03

Applicant: BASF AG

Inventor： EMLING FRANZ ,  HAUPT ANDREAS ,  ROMERDAHL CYNTHIA A

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/04 ,  C07K5/103 ,  C07K7/06

Abstract: Novel compounds of the formulaR1R2N-CHX-CO-A-B-D-(E)s-(F)t-(G)U-KIin which R1, R2, A, B, D, E, F, G, K, X, s, t, and u have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.

公开(公告)号：SK165497A3

公开(公告)日：1998-08-05

申请号：SK165497

申请日：1996-06-03

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  EMLING FRANZ ,  ROMERDAHL CYNTHIA A

IPC: A61K38/08 ,  C07K7/06

Abstract: Peptides of general formula (I) R1R2N - CHX - CO - A - B - D - E - (F)t - K, wherein R1 is methyl, ethyl or isopropyl, R2 is H, methyl or ethyl, R1-N-R2 together pyrrolidine ring, A residues of Val, Ile, Leu, 2-terc-butylglycyl, 2-ethylglycyl, norleucyl or norvalyl, B residues of N-methyl-valyl, N-methylleucyl, N-methylisoleucyl, N-methylnorvalyl, N-methylnorleucyl, N-methyl-2-terc-butylglycyl, N-methyl-3-terc-butylalanyl or N-methyl- 2-ethylglycyl, D residues pro, 3,4-dehydroprolyl, 4-fluoroprolyl, 4,4-difluoropropyl, asetidine-2-carbonyl, homoprolyl, 3-methylprolyl, 4-methylprolyl, 5-methylprolyl or thiazolidine-4-carbonyl, E 3,4-dehydroprolyl, 4-fluoroprolyl, 3-methylprolyl, 4-methylprolyl, azetidine-2-carbonyl or 4,4-difluoroprolyl, F residues of Val, 2-tec-butylglycyl, Ile, Leu, 2-cyclohexylglycyl, norleucyl, norvalyl, neopentylglycyl, Ala, beta-Ala or amino isobutyroyl, X alkyl, cyclopropyl or cyclopentyl, T is 0 or 1, K alkoxy group, benzyloxy group or group R5-N-R6, or their salts with physiologically suitable acids, pharmaceutical preparation containing them and their use in the medicine, particularly for treatment of oncological diseases and mammals tumours.

公开(公告)号：PL323723A1

公开(公告)日：1998-04-14

申请号：PL32372396

申请日：1996-06-03

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  EMLING FRANZ ,  ROMERDAHL CYNTHIA A

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/04 ,  C07K5/103 ,  C07K7/06 ,  C07K7/08

Abstract: Novel compounds of the formulaR1R2N-CHX-CO-A-B-D-(E)s-(F)t-(G)U-KIin which R1, R2, A, B, D, E, F, G, K, X, s, t, and u have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.

公开(公告)号：ZA964711B

公开(公告)日：1997-12-08

申请号：ZA964711

申请日：1996-06-06

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  EMLING FRANZ ,  ROMERDAHL CYNTHIA A

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/04 ,  C07K5/103 ,  C07K7/06 ,  A61K ,  C07K

Abstract: Novel compounds of the formulaR1R2N-CHX-CO-A-B-D-(E)s-(F)t-(G)U-KIin which R1, R2, A, B, D, E, F, G, K, X, s, t, and u have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.

公开(公告)号：ZA9604710B

公开(公告)日：1997-12-08

申请号：ZA9604710

申请日：1996-06-06

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  EMLING FRANZ ,  ROMERDAHL CYNTHIA A

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/04 ,  C07K5/103 ,  C07K7/06 ,  C07K ,  A61K

CPC classification number: C07K7/06 ,  A61K38/00 ,  C07K5/101

公开(公告)号：CA2219819C

公开(公告)日：2008-05-20

申请号：CA2219819

申请日：1996-06-03

Applicant: BASF AG

Inventor： EMLING FRANZ ,  ROMERDAHL CYNTHIA A ,  HAUPT ANDREAS

IPC: A61K38/00 ,  C07K7/06 ,  A61K38/07 ,  A61K38/08 ,  A61P35/00 ,  C07K1/04 ,  C07K5/10 ,  C07K5/103

Abstract: Novel dolasstatin derivatives of the formula (I): R1R2N-CHX-CO-A-B-D-E-(F)t K, in which R1, R2, A, B, D, E, F, K, X and t have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.

公开(公告)号：CA2219818C

公开(公告)日：2008-05-20

申请号：CA2219818

申请日：1996-06-03

Applicant: BASF AG

Inventor： ROMERDAHL CYNTHIA A ,  HAUPT ANDREAS ,  EMLING FRANZ

IPC: A61K38/00 ,  C07K7/06 ,  A61K38/07 ,  A61K38/08 ,  A61P35/00 ,  C07K1/04 ,  C07K5/10 ,  C07K5/103

Abstract: Novel dolastatin derivatives of the formula (I): R1R2N-CHX-CO-A- B-D-E-(F)t-K in which R1, R2, A, B, D, E, F, K, X and t have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.

公开(公告)号：MY119042A

公开(公告)日：2005-03-31

申请号：MYPI9602155

申请日：1996-06-03

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  ROMERDAHL CYNTHIA A ,  EMLING FRANZ

IPC: A61K38/00 ,  C07K7/06 ,  A61K38/08 ,  A61P35/00 ,  C07K1/04 ,  C07K5/103

Abstract: NOVEL COMPOUNDS OF THE FORMULA :R1R2N-CHX-CO-A-B-D-E-(F)T-K IIN WHICH R1, R2, A, B, D, E, F, K, X, AND T HAVE THE MEANINGS STATED IN THE DESCRIPTION, AND THE PREPARATION THEREOF ARE DESCRIBED. THE NOVEL SUBSTANCES HAVE AN ANTINEOPLASTIC EFFECT.