公开(公告)号：EP2358678A1

公开(公告)日：2011-08-24

申请号：EP09751875.7

申请日：2009-11-03

Applicant: BASF SE

Inventor： MENGES, Frederik ,  GEBHARDT, Joachim ,  RACK, Michael ,  KEIL, Michael ,  KLIMA, Rodney F. ,  CORTES, David. ,  LEICHT, Robert ,  ZECH, Helmut ,  SCHRÖDER, Jochen

IPC: C07D213/81 ,  C07D401/04 ,  C07D405/04

CPC classification number: C07D491/048 ,  C07D213/803 ,  C07D213/81 ,  C07D401/04 ,  C07D405/04

Abstract: A process for manufacturing 5-chloromethyl-2,3-pyridine dicarboxylic acid anhydrides (I) wherein Z is hydrogen or halogen; Z
1 is hydrogen, halogen, cyano or nitro; comprising the steps of (i) reacting a compound of formula (II), wherein the symbols have the meaning given in formula (I), with a chlorinating agent, optionally in the presence of a radical initiator in a solvent selected from halogenated hydrocarbons, and (ii) crystallizing the compound (I) formed in step (i) from a solvent selected from chlorobenzene, 1,2-dichlorobenzene, 1,3-dichlorobenzene, 1,4-dichlorobenzene, dichloroethane, trichloromethane, dichloromethane, toluene, xylenes, ethyl acetate, methyl tert.-butyl ether, and mixtures thereof. Compounds (I) are useful intermediates in the synthesis of herbicidal imidazolinones.

Abstract translation: 一种制备其中Z是氢或卤素的5-氯甲基-2,3-吡啶二羧酸酸酐（Ⅰ）的方法; Z 1是氢，卤素，氰基或硝基; 包括以下步骤：（i）使式（II）化合物（其中符号具有式（I）中给出的含义）与氯化剂任选在自由基引发剂存在下在选自卤代烃， （ii）使步骤（i）中形成的化合物（I）从选自氯苯，1,2-二氯苯，1,3-二氯苯，1,4-二氯苯，二氯乙烷，三氯甲烷，二氯甲烷，甲苯，二甲苯 ，乙酸乙酯，甲基叔丁基醚及其混合物。 化合物（I）是合成除草咪唑啉酮的有用中间体。

公开(公告)号：EP2376472B1

公开(公告)日：2015-08-19

申请号：EP09764528.7

申请日：2009-12-07

Applicant: BASF SE

Inventor： RACK, Michael ,  GEBHARDT, Joachim ,  MENGES, Frederik ,  KEIL, Michael ,  KLIMA, Rodney F. ,  CORTES, David ,  LEICHT, Robert ,  ZECH, Helmut ,  SCHRÖDER, Jochen

IPC: C07D401/04 ,  C07D213/80

CPC classification number: C07D213/80

公开(公告)号：EP2547687B1

公开(公告)日：2015-07-01

申请号：EP11708836.9

申请日：2011-03-15

Applicant: BASF SE

Inventor： DOCHNAHL, Maximilian ,  KEIL, Michael ,  GEBHARDT, Joachim ,  VOGELBACHER, Uwe Josef ,  MENGES, Frederik ,  RACK, Michael ,  RENNER, Jens ,  WOLF, Bernd

IPC: C07F3/00 ,  C07F3/02 ,  C07D405/06

CPC classification number: A01N43/653 ,  A01N55/00 ,  C07D249/08 ,  C07D403/04 ,  C07D405/06 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D487/08 ,  C07F3/003 ,  C07F3/02

公开(公告)号：EP2585436A1

公开(公告)日：2013-05-01

申请号：EP11797708.2

申请日：2011-06-20

Applicant: BASF SE

Inventor： MAYWALD, Volker ,  MENGES, Frederik ,  VOGELBACHER, Uwe Josef ,  RACK, Michael ,  KEIL, Michael ,  GRAMMENOS, Wassilios ,  VRETTOU-SCHULTES, Marianna ,  LOHMANN, Jan Klaas ,  MÜLLER, Bernd ,  JABS, Thorsten

IPC: C07D213/68 ,  C07D213/61

CPC classification number: C07D213/68 ,  C07D213/08 ,  C07D213/61

Abstract: A process for preparing 4-hydroxypyridines of formula I, wherein R
1 , R
2 , R
3 and R
4 have the meaning defined in the description.

公开(公告)号：EP2376472A1

公开(公告)日：2011-10-19

申请号：EP09764528.7

申请日：2009-12-07

Applicant: BASF SE

Inventor： RACK, Michael ,  GEBHARDT, Joachim ,  MENGES, Frederik ,  KEIL, Michael ,  KLIMA, Rodney F. ,  CORTES, David ,  LEICHT, Robert ,  ZECH, Helmut ,  SCHRÖDER, Jochen

IPC: C07D401/04 ,  C07D213/80

CPC classification number: C07D213/80

Abstract: A process for manufacturing a 5-formyl-pyridine-2,3-dicarboxylic acid ester (I) wherein Z is hydrogen or halogen; Z
1 is hydrogen, halogen, cyano or nitro and R
1 , R
2 are independently C
1 -C
10 -alkyl, comprising the steps of (i) reacting a compound of formula (II), wherein the symbols are as in formula (I), with a nitrosation agent (III) R
3 -O-N=O (III) wherein R
3 is C
1 -C
8 -alkyl, in the presence of an alkali metal or alkaline earth metal alcoholates or carbonates in a polar aprotic solvent at a temperature of from -45 to 40°C, to obtain an oxime compound (IV) where Z, Z
1 , R
1 and R
2 are as in formula (I), and (ii) reacting oxime compound (IV) with an aliphatic C
1 -C
10 -aldehyde in the presence of a Lewis acid at a temperature in the range of from 0 to 100°C. The compounds of formula (I) are useful intermediates in the synthesis of herbicidal imidazolinones, like imazamox.

公开(公告)号：EP2370410A1

公开(公告)日：2011-10-05

申请号：EP09745045.6

申请日：2009-11-03

Applicant: BASF SE

Inventor： MENGES, Frederik ,  GEBHARDT, Joachim ,  RACK, Michael ,  KEIL, Michael ,  KLIMA, Rodney F. ,  CORTES, David ,  LEICHT, Robert ,  ZECH, Helmut ,  SCHRÖDER, Jochen

IPC: C07D213/81 ,  C07D401/04

CPC classification number: C07D401/04 ,  C07D213/81

Abstract: 2-[(1-cyanopropyl)carbamoyl]-5-chloromethyl nicotinic acids of formula (I) where Z is hydrogen or halogen; Z
1 is hydrogen, halogen, cyano or nitro; R
1 is C
1 -C
4 alkyl; R
2 is C
1 -C
4 alkyl, C
3 -C
6 cycloalkyl or R
1 and R
2 , when taken together with the atom to which they are attached, represent a C
3 -C
6 cycloalkyl group optionally substituted with methyl, and R
3 is hydrogen or a cation preferably selected from the group consisting of alkali metals, alkaline earth metals, manganese, copper, iron, zinc, cobalt, lead, silver, nickel, ammonium and organic ammonium; are useful intermediates for the synthesis of herbicidal imidazolinones.