公开(公告)号：US20200331829A1

公开(公告)日：2020-10-22

申请号：US16756961

申请日：2018-10-31

Applicant: BASF SE

Inventor： Daniel Saelinger ,  Philip Muelheims ,  Helmut Zech ,  Roland Goetz

IPC: C07C41/16

Abstract: The present invention relates to a process for preparing 4-chlorobenzyl propargylether comprising a step (a) of reacting 4-chlorobenzyl chloride with propargyl alcohol in the presence of a base and a phase transfer catalyst, wherein the reaction mixture comprises at least two phases, wherein one phase is an organic phase and one phase is an aqueous phase.

公开(公告)号：US20200157064A1

公开(公告)日：2020-05-21

申请号：US16634202

申请日：2018-07-21

Applicant: BASF SE

Inventor： Christopher Koradin ,  Wassilios Grammenos ,  Michael Rack ,  Kailaskumar Borate ,  Roland Goetz

IPC: C07D271/06

Abstract: The present invention relates to a process for the preparation of substituted 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles (compounds I), which can be obtained through reaction of hydroxyamidine compounds of formula II with trifluoroacetyl halides IIa.

公开(公告)号：US09512093B2

公开(公告)日：2016-12-06

申请号：US14899755

申请日：2014-06-17

Applicant: BASF SE

Inventor： Timo Frassetto ,  Maximilian Dochnahl ,  Michael Rack ,  Volker Maywald ,  Bernd Wolf ,  Roland Goetz ,  Philip Muelheims ,  Rudolf Haeberle

IPC: C07D265/36 ,  C07C17/16 ,  C07D413/04

CPC classification number: C07D265/36 ,  C07C17/16 ,  C07D413/04 ,  C07C21/22

Abstract: The present invention relates to a process for manufacturing 4-propargylated amino-benzoxazinones of formula (I), comprising the following steps: step a) preparing propargyl chloride by reacting propargyl alcohol with thionyl chloride optionally in the presence of a catalyst; and step b) reacting the propargyl chloride prepared in step (a) with a NH-benzoxazinone of formula (II); wherein the variables are defined according to the description.

公开(公告)号：US20240101547A1

公开(公告)日：2024-03-28

申请号：US18272840

申请日：2022-01-21

Applicant: BASF SE

Inventor： Christopher Koradin ,  Martin John McLaughlin ,  Roland Goetz ,  Rahul Kaduskar ,  Harish Shinde ,  Guillaume Michel Jacques Garivet

IPC: C07D417/12

CPC classification number: C07D417/12

Abstract: The present invention relates to a method for preparing 2-[2-(2-chlorothiazol-5-yl)-2-oxo-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof, to 2-[2-(2-chlorothiazol-5-yl)-2-oxo-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one or a tautomer thereof and to its use as intermediate in the preparation of 2,3-dihydrotheiazolo [3,2-a]pyrimidinium compounds, and specifically of 3-(2-chlorothiazol-5-yl)-8-methyl-7-oxo-6-phenyl-2,3-dihydrothiazolo [3,2-a]pyrimidin-4-ium-5-olate and enantiomerically enriched forms thereof.

公开(公告)号：US20230242493A1

公开(公告)日：2023-08-03

申请号：US17766286

申请日：2020-10-20

Applicant: BASF SE

Inventor： Birgit Gockel ,  Volker Maywald ,  Manfred Ehresmann ,  Daniel Saelinger ,  Roland Goetz ,  Jan Haller

IPC: C07D257/04

CPC classification number: C07D257/04

Abstract: Process for making a compound represented by formula (3), comprising the following steps: a) reacting an azide compound with a compound represented by formula (1) to yield compound (2), compound (2) being a compound represented by formula (2) or its salts, b) methylating compound (2) obtained in step a) using a methylating agent to obtain compound (3), wherein R1 denotes a hydrocarbon rest, and wherein in step a) a solvent system A and in step b) a solvent system B is used, wherein both solvent systems A and B comprise one dipolar aprotic solvent or a mixture of dipolar aprotic solvents as the main component, and wherein steps a) and b) are carried without isolating the compound (2) obtained in step a).

公开(公告)号：US20230183171A1

公开(公告)日：2023-06-15

申请号：US17925873

申请日：2021-05-20

Applicant: BASF SE

Inventor： Florian Vogt ,  Kailaskumar Borate ,  Bernd Wolf ,  Joachim Gebhardt ,  Guillaume Michel Jacques Garivet ,  Harish Shinde ,  Roland Goetz

IPC: C07C259/18 ,  C12P13/00 ,  C07D271/06

CPC classification number: C07C259/18 ,  C12P13/002 ,  C07D271/06

Abstract: The present invention relates to a process for the preparation of substituted 4-(N′-hydroxy-carbamimidoyl)benzoic acids, which can be obtained by nitrilase catalyzed hydration of substituted terephthalonitriles of formula (II) in an aqueous medium to afford (ammonium) 4-cyanobenzoic acids (IIa). The hydration is followed by treatment of the aqueous reaction medium with hydroxylamine or a salt thereof to afford amidoximes (I).

公开(公告)号：US20230127884A1

公开(公告)日：2023-04-27

申请号：US17918137

申请日：2021-04-12

Applicant: BASF SE

Inventor： Florian Vogt ,  Joachim Gebhardt ,  Kailaskumar Borate ,  Bernd Wolf ,  Heinz Friedrich Sutoris ,  Roland Goetz

IPC: C07C253/30 ,  C07D271/06

Abstract: The present invention relates to a process for the preparation of 4-cyanobenzoyl chlorides of formula I through reaction of compounds of formula II with a chlorinating agent.

公开(公告)号：US11261145B2

公开(公告)日：2022-03-01

申请号：US16495424

申请日：2018-03-12

Applicant: BASF SE

Inventor： Bernd Schaefer ,  Roland Goetz ,  Volker Hickmann ,  Volker Maywald ,  Daniel Saelinger

IPC: C07C17/10 ,  B01J19/12

Abstract: The present invention relates to a process for preparing bromotrichloromethane comprising a) providing bromine in chloroform; and b) radiation of the resulting solution with light in the range of 350 to 550 nm, wherein said solution of bromine in chloroform is not radiated with radiation of a wavelength below 350 nm.

公开(公告)号：US20220017931A1

公开(公告)日：2022-01-20

申请号：US17424824

申请日：2020-01-20

Applicant: BASF SE

Inventor： Diego Ghislieri ,  Christian Willrodt ,  Christopher Koradin ,  Stefan Seemayer ,  Doreen Schachtschabel ,  Kai-Uwe Baldenius ,  Roland Goetz

IPC: C12P13/00 ,  C12N9/78

Abstract: Described herein are methods for the production of 4-cyano benzoic acid or salts thereof from terephthalonitrile using nitrilase as catalyst. Also described herein are compositions including 4-cyano benzoic acid.

公开(公告)号：US20210380569A1

公开(公告)日：2021-12-09

申请号：US17288976

申请日：2019-10-28

Applicant: BASF SE

Inventor： Roland Goetz ,  Michael Rack ,  Martin John McLaughlin ,  Harish Shinde ,  Ritesh Karalkar ,  Kailaskumar Borate ,  Karsten Koerber ,  Arun Narine ,  Nikolas Huwyler

IPC: C07D413/04 ,  B01J31/02

Abstract: The invention relates to a process for preparing optically enriched isoxazoline compounds of formula (I), wherein the variables are as defined in the specification, and the shown enantiomer has at least 80% ee; by oxo-Michael addition of hydroxyl amine or its salt to an enone of formula (II), wherein the variables have the meanings given for formula (I), in the presence of a catalyst of formula (III) and a base.