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    Chromophores in the preparation of novel tandem conjugates
    21.
    发明专利
    Chromophores in the preparation of novel tandem conjugates 未知

    公开(公告)号：AU9681498A

    公开(公告)日：1999-04-27

    申请号：AU9681498

    申请日：1998-10-01

    Applicant: BECTON DICKINSON CO

    Inventor： DAVIS KENNETH A ,  BISHOP JAMES A JR ,  ABRAMS BARNABY

    IPC: G01N33/532 ,  G01N33/533 ,  G01N33/58

    Abstract: The inventors herein disclose new heterobifunctional chromophores that are capable of coupling with two distinct moieties. One moiety may be either a signal-enhancing agent or a blocking agent. The second moiety may be one member of a specific binding pair. The invention is based in part on the surprising result that when a chromophore is used as a "cross-linker" between a signal-enhancing agent and a member of a binding pair (essentially being buried between the two), the signal of the chromophore is not quenched. This arrangement, wherein the chromophore acts simultaneously as a cross-linker and a detectable compound, provides significant advantages over previously known compounds since the chromophore is sterically hindered from interacting non-specifically with substances present in the test systems. Moreover, the chromophore can be used as a cross-linker with little or no loss of detectable signal.

    23.
    发明专利
    未知

    公开(公告)号：DE69837924T2

    公开(公告)日：2007-10-18

    申请号：DE69837924

    申请日：1998-10-01

    Applicant: BECTON DICKINSON CO

    Inventor： DAVIS KENNETH A ,  BISHOP JAMES A ,  ABRAMS BARNABY

    IPC: G01N33/532 ,  G01N33/533 ,  G01N33/58

    Abstract: The inventors herein disclose new heterobifunctional chromophores that are capable of coupling with two distinct moieties. One moiety may be either a signal-enhancing agent or a blocking agent. The second moiety may be one member of a specific binding pair. The invention is based in part on the surprising result that when a chromophore is used as a "cross-linker" between a signal-enhancing agent and a member of a binding pair (essentially being buried between the two), the signal of the chromophore is not quenched. This arrangement, wherein the chromophore acts simultaneously as a cross-linker and a detectable compound, provides significant advantages over previously known compounds since the chromophore is sterically hindered from interacting non-specifically with substances present in the test systems. Moreover, the chromophore can be used as a cross-linker with little or no loss of detectable signal.

    24.
    发明专利
    未知

    公开(公告)号：DE69626147T2

    公开(公告)日：2003-10-23

    申请号：DE69626147

    申请日：1996-03-27

    Applicant: BECTON DICKINSON CO

    Inventor： DAVIS KENNETH A ,  BISHOP JAMES E

    IPC: G01N15/10 ,  G01N15/14 ,  G01N33/58 ,  G01N33/96

    Abstract: A rapid, simple method for preparing beads for calibrating flow cytometers which contain a known number of fluorophores per bead is presented. Briefly, the invention utilizes beads coated with a stable complex of a fluorophore and an enzyme. the enzymatic activity of a known number of beads gives an accurate measure of fluorophore density on those beads.

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