公开(公告)号：US20130245378A1

公开(公告)日：2013-09-19

申请号：US13785262

申请日：2013-03-05

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Thomas E. Milner ,  Nathaniel J. Kemp

IPC: A61B1/00

CPC classification number: A61B1/00163 ,  A61B1/0011 ,  A61B1/00172 ,  A61B5/0066 ,  A61B5/6852 ,  Y10T29/49826

Abstract: The invention is a rotating tip catheter-imaging probe where electromagnetic energy is delivered to the distal end of a catheter and converted to mechanical energy using a light drive apparatus. The mechanical energy is then used to rotate a mirror that redirects light in fixed pattern on a sample. The rotating element of the light drive apparatus contains vanes, which rotate about an axis and positioned with bearings to minimize friction. A chamber encompasses the rotating element and is set to a vacuum pressure. The rotational speed of the catheter tip can be controlled by varying the optical power delivered to the vanes, the vacuum pressure in the chamber, or by a braking mechanism applied to the rotating element. The vanes may be shaped in a particular geometry to increase forces on the vanes from thermally driven gas flow.

Abstract translation: 本发明是旋转尖端导管成像探针，其中电磁能量被传送到导管的远端并且使用光驱动装置转换成机械能。 然后机械能用于旋转将固定模式的光重定向在样品上的反射镜。 光驱装置的旋转元件包含叶片，叶片绕轴线转动并且与轴承一起定位以使摩擦力最小化。 腔室包围旋转元件并被设定为真空压力。 可以通过改变输送到叶片的光功率，腔室中的真空压力，或通过施加到旋转元件的制动机构来控制导管尖端的旋转速度。 叶片可以成形为特定的几何形状以增加来自热驱动气流的叶片上的力。

公开(公告)号：US09591961B2

公开(公告)日：2017-03-14

申请号：US13785262

申请日：2013-03-05

Applicant: Board of Regents, The University of Texas System

Inventor： Thomas E. Milner ,  Nathaniel J. Kemp

IPC: A61B5/00 ,  A61B1/00

CPC classification number: A61B1/00163 ,  A61B1/0011 ,  A61B1/00172 ,  A61B5/0066 ,  A61B5/6852 ,  Y10T29/49826

Abstract: The invention is a rotating tip catheter-imaging probe where electromagnetic energy is delivered to the distal end of a catheter and converted to mechanical energy using a light drive apparatus. The mechanical energy is then used to rotate a mirror that redirects light in fixed pattern on a sample. The rotating element of the light drive apparatus contains vanes, which rotate about an axis and positioned with bearings to minimize friction. A chamber encompasses the rotating element and is set to a vacuum pressure. The rotational speed of the catheter tip can be controlled by varying the optical power delivered to the vanes, the vacuum pressure in the chamber, or by a braking mechanism applied to the rotating element. The vanes may be shaped in a particular geometry to increase forces on the vanes from thermally driven gas flow.

Abstract translation: 本发明是旋转尖端导管成像探针，其中电磁能量被传送到导管的远端并且使用光驱动装置转换成机械能。 然后机械能用于旋转将固定模式的光重定向在样品上的反射镜。 光驱装置的旋转元件包含叶片，叶片绕轴线转动并且与轴承一起定位以使摩擦力最小化。 腔室包围旋转元件并被设定为真空压力。 可以通过改变输送到叶片的光功率，腔室中的真空压力，或通过施加到旋转元件的制动机构来控制导管尖端的旋转速度。 叶片可以成形为特定的几何形状以增加来自热驱动气流的叶片上的力。

公开(公告)号：US20160150961A1

公开(公告)日：2016-06-02

申请号：US14954936

申请日：2015-11-30

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Thomas E. Milner

IPC: A61B5/00 ,  A61N2/02 ,  A61B5/026

CPC classification number: A61B5/0066 ,  A61B5/0035 ,  A61B5/026 ,  A61B5/0261 ,  A61B5/0275 ,  A61B5/05 ,  A61B5/0515 ,  A61B5/6852 ,  A61B5/725 ,  A61B8/06 ,  A61B8/13 ,  A61B8/488 ,  A61B2576/00 ,  A61N2/02 ,  G01N21/1717 ,  G01N21/4795

Abstract: Provided herein are systems, methods, and compositions for the use of optical coherence tomography for detection of cells.

公开(公告)号：US09168388B2

公开(公告)日：2015-10-27

申请号：US13693974

申请日：2012-12-04

Applicant: Board of Regents, The University of Texas System

Inventor： Christopher G. Rylander ,  Thomas E. Milner ,  Oliver Stumpp ,  J. Stuart Nelson

IPC: G02C7/10 ,  A61N5/06 ,  A61B5/00 ,  A61B18/20 ,  A61B18/14 ,  A61B18/18 ,  A61B17/30 ,  A61B18/00

CPC classification number: A61N5/06 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/444 ,  A61B18/14 ,  A61B18/1815 ,  A61B18/203 ,  A61B2017/306 ,  A61B2018/00029 ,  A61B2018/00035 ,  A61B2018/00452 ,  A61B2018/00994 ,  A61N5/0616 ,  A61N5/062 ,  A61N2005/063 ,  A61N2005/0649

Abstract: Embodiments of the present disclosure provides systems, devices, and methods for non-invasively modifying, maintaining, or controlling local tissue optical properties. Methods and devices of the disclosure may be used for optically clearing tissue, for example, for diagnostic and/or therapeutic purposes. A method of optically clearing a tissue may comprise contacting the tissue with an optical clearing device having a base, an array of pins fixed to one side of the base, a brim fixed to the base, an inlet port in the base, an exit port in the base, and a handpiece interface tab fixed to the side of the base opposite the array of pins, applying a mechanical force to the tissue, and illuminating said tissue with at least one wavelength of light through the optical clearing device. A method may further comprise controlling the temperature of the tissue illuminated.

Abstract translation: 本公开的实施例提供用于非侵入性地修改，维持或控制局部组织光学性质的系统，装置和方法。 本公开的方法和装置可用于光学清除组织，例如用于诊断和/或治疗目的。 光学清理组织的方法可以包括使组织与光学清除装置接触，所述光学清除装置具有底座，固定到基座的一侧的销的阵列，固定到基座的边缘，基座中的入口端口，出口 在底座中，以及手柄接口片，其固定在基座对面的与针阵列相对的一侧上，向组织施加机械力，并且通过光学清除装置用至少一个波长的光照射所述组织。 方法还可以包括控制照射的组织的温度。

公开(公告)号：US20130197346A1

公开(公告)日：2013-08-01

申请号：US13722553

申请日：2012-12-20

Applicant: Board of Regents, The University of Texas System

Inventor： Thomas E. Milner

IPC: A61B5/05 ,  A61B8/08 ,  A61B5/00

CPC classification number: A61B5/0066 ,  A61B5/0035 ,  A61B5/026 ,  A61B5/0261 ,  A61B5/0275 ,  A61B5/05 ,  A61B5/0515 ,  A61B5/6852 ,  A61B5/725 ,  A61B8/06 ,  A61B8/13 ,  A61B8/488 ,  A61B2576/00 ,  A61N2/02 ,  G01N21/1717 ,  G01N21/4795

Abstract: Provided herein are systems, methods, and compositions for the use of optical coherence tomography for detection of cells.

Abstract translation: 本文提供了使用光学相干断层摄影术来检测细胞的系统，方法和组合物。