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1.发明授权Hemoglobin contrast in ultrasound and optical coherence tomography for diagnosing diseased tissue, cancers, and the like 有权用于诊断患病组织，癌症等的超声和光学相干断层扫描中的血红蛋白对比度公开(公告)号：US09532718B2
公开(公告)日：2017-01-03
申请号：US14959379
申请日：2015-12-04
Inventor： Marc D. Feldman , Thomas E. Milner , Jung-Hwan Oh
CPC classification number: A61B5/0066 , A61B5/0073 , A61B5/05 , A61B5/14546 , A61B8/06 , A61B8/488
Abstract: A novel contrast mechanism for diagnosing diseased tissue using Ultrasound, Doppler Ultrasonography, Optical Coherence Tomography, or optical Doppler tomography coupled with an externally applied temporally oscillating high-strength magnetic field.
Abstract translation: 一种用于使用超声，多普勒超声，光学相干断层扫描或与外部施加的时间振荡的高强度磁场耦合的光学多普勒断层摄影来诊断患病组织的新型对比机制。
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公开(公告)号：US09526425B2
公开(公告)日：2016-12-27
申请号：US13904849
申请日：2013-05-29
Inventor： Marc D. Feldman , Thomas E. Milner , Jung-Hwan Oh , Eunha Kim , Karathik Kumar , Jonathan C. Condit , Robert Grant , Nathaniel J. Kemp , Jihoon Kim , Shaochen Chen , Li-Hsin Han
CPC classification number: A61B5/0073 , A61B1/00096 , A61B1/00167 , A61B1/00172 , A61B5/0066 , A61B5/0084 , A61B5/6852
Abstract: The embodiments disclosed herein is a system for optical coherence tomographic imaging of turbid (i.e., scattering) materials utilizing multiple channels of information. The multiple channels of information may encompass spatial, angle, spectral and polarization domains. More specifically, the embodiments disclosed herein is related to methods and apparatus for utilizing optical sources, systems or receivers capable of providing (source), processing (system) or recording (receiver) a multiplicity of channels of spectral information for optical coherence tomographic imaging of turbid materials. In these methods and apparatus the multiplicity of channels of spectral information that can be provided by the source, processed by the system, or recorded by the receiver are used to convey simultaneously spatial, spectral or polarimetric information relating to the turbid material being imaged tomographically. The multichannel optical coherence tomographic methods can be incorporated into an endoscopic probe for imaging a patient.
Abstract translation: 本文公开的实施例是利用多个信道信道的混浊（即，散射）材料的光学相干断层成像系统。 信息的多个信道可以包括空间，角度，光谱和极化域。 更具体地说，这里公开的实施例涉及用于利用光源，系统或接收器的方法和装置，该光源，系统或接收器能够提供（源），处理（系统）或记录（接收）多个光谱信息通道，用于光学相干断层成像 浑浊的材料。 在这些方法和装置中，可以由源提供的，由系统处理或由接收机记录的光谱信息的多个信道的多样性被用于同时传送与被层析成像的浑浊材料有关的空间，光谱或偏振信息。 多通道光学相干断层摄影方法可以并入用于成像患者的内窥镜探针中。
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3.发明授权Polarization-sensitive spectral interferometry as a function of depth for tissue identification 有权作为组织鉴定深度的函数的极化敏感光谱干涉测量公开(公告)号：US09423237B2
公开(公告)日：2016-08-23
申请号：US14041335
申请日：2013-09-30
Inventor： Thomas E. Milner , Nathaniel J. Kemp , Eunha Kim
CPC classification number: G01B9/02091 , A61B1/00096 , A61B1/00167 , A61B1/00172 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/4523 , A61B5/6852 , A61B5/7257 , G01B9/02004 , G01B9/02069 , G01B9/02097 , G01B2290/70
Abstract: A polarization sensitive spectral interferometer apparatus and method for analyzing a sample by optical energy reflected from the sample. The polarization sensitive spectral interferometer apparatus and method determines polarization properties of the sample by optical energy reflected from the sample. The method for analyzing a sample with a spectral interferometer identifies the tissue type of the sample by the polarization properties as a function of depth from the sample.
Abstract translation: 一种用于通过从样品反射的光能分析样品的偏振敏感光谱干涉仪装置和方法。 偏振敏感光谱干涉仪装置和方法通过从样品反射的光能确定样品的偏振特性。 用光谱干涉仪分析样品的方法通过偏振特性作为样品深度的函数来识别样品的组织类型。
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4.发明授权公开(公告)号：US09326719B2
公开(公告)日：2016-05-03
申请号：US13720563
申请日：2012-12-19
Inventor： Taner Akkin , Thomas E. Milner , Digant P. Dave , H. Grady Rylander, III
CPC classification number: A61B5/4041 , A61B5/0066 , A61B5/0075 , A61B5/0082 , A61B5/40 , A61B5/4029 , A61B5/6821 , A61B5/7225 , A61B5/7282 , A61N1/00 , A61N1/3605 , A61N5/0622
Abstract: Optical methods, devices, and systems for noninvasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflect ion coatings are not required. Transient neural surface displacement of less then 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.
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5.发明申请SYSTEM AND METHOD FOR SCORING THE LEFT VENTRICULAR ENDOCARDIUM TO INCREASE LEFT VENTRICULAR COMPLIANCE 审中-公开用于评估左心室内膜以增加左心室合并的系统和方法公开(公告)号：US20150265304A1
公开(公告)日：2015-09-24
申请号：US14433763
申请日：2013-10-07
Inventor： Marc D. Feldman , Daniel Escobedo , David L. Halaney , Jordan C. Dwelle , Austin B. McElroy , Thomas E. Milner
IPC: A61B17/32 , A61B17/00 , A61B17/3209
CPC classification number: A61B17/320016 , A61B17/00234 , A61B17/295 , A61B17/320725 , A61B17/3209 , A61B18/14 , A61B18/24 , A61B2017/00243 , A61B2017/00247 , A61B2017/00876 , A61B2017/22061 , A61B2017/320052 , A61B2017/3425
Abstract: In some embodiments, a system for scoring human endocardium tissue may include a first conduit and an activation system. The first conduit may include a first opening, a second opening, and a cutting device. The first opening may be positioned at a proximal end of the first conduit. The second opening may extend from adjacent to a closed distal end portion of the first conduit. The cutting device, when activated, may cut through a portion of a depth of endocardium tissue positioned adjacent the second opening. The cutting device may selectively cut or score the endocardium to a specified depth and length in the endocardium of a left ventricle of a human heart.
Abstract translation: 在一些实施例中，用于对人心内膜组织进行评分的系统可以包括第一导管和激活系统。 第一导管可以包括第一开口，第二开口和切割装置。 第一开口可以位于第一导管的近端。 第二开口可以从第一导管的封闭的远端部分的相邻延伸。 当切割装置被激活时，切割装置可以切穿邻近第二开口定位的心内膜组织深度的一部分。 切割装置可以选择性地将心内膜切割或评分到人心脏左心室心内膜的指定深度和长度。
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Patent Agency Ranking
公开(公告)号：US20140098373A1
公开(公告)日：2014-04-10
申请号：US14041335
申请日：2013-09-30
Inventor： Thomas E. Milner , Nathaniel J. Kemp , Eunha Kim
IPC: G01B9/02
CPC classification number: G01B9/02091 , A61B1/00096 , A61B1/00167 , A61B1/00172 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/4523 , A61B5/6852 , A61B5/7257 , G01B9/02004 , G01B9/02069 , G01B9/02097 , G01B2290/70
Abstract: A polarization sensitive spectral interferometer apparatus and method for analyzing a sample by optical energy reflected from the sample. The polarization sensitive spectral interferometer apparatus and method determines polarization properties of the sample by optical energy reflected from the sample.
Abstract translation: 一种用于通过从样品反射的光能分析样品的偏振敏感光谱干涉仪装置和方法。 偏振敏感光谱干涉仪装置和方法通过从样品反射的光能确定样品的偏振特性。
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公开(公告)号：US20130331701A1
公开(公告)日：2013-12-12
申请号：US13900087
申请日：2013-05-22
Inventor： Thomas E. Milner , Marc D. Feldman , Christopher Condit , Jung-Hwan Oh
CPC classification number: A61B8/481 , A61B5/0048 , A61B5/0515 , A61B5/415 , A61B5/416 , A61B5/418 , A61B8/08 , A61B8/0816 , A61B8/0833 , A61B8/12 , A61B8/13 , A61B8/486 , A61B8/488
Abstract: Provided herein are systems, methods and compositions for the use of ultrasound for detection of cells and nanoparticles.
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8.发明授权Hemoglobin contrast in magneto-motive optical doppler tomography, optical coherence tomography, and ultrasound imaging methods and apparatus 有权磁共振光学多普勒层析成像，光学相干断层扫描和超声成像方法和装置中的血红蛋白对比公开(公告)号：US09198596B2
公开(公告)日：2015-12-01
申请号：US13722553
申请日：2012-12-20
Inventor： Thomas E. Milner
IPC: A61B5/055 , A61B5/05 , A61B5/00 , A61B5/0275 , A61B8/06 , A61B8/13 , G01N21/17 , G01N21/47 , A61B8/08
CPC classification number: A61B5/0066 , A61B5/0035 , A61B5/026 , A61B5/0261 , A61B5/0275 , A61B5/05 , A61B5/0515 , A61B5/6852 , A61B5/725 , A61B8/06 , A61B8/13 , A61B8/488 , A61B2576/00 , A61N2/02 , G01N21/1717 , G01N21/4795
Abstract: Provided herein are systems, methods, and compositions for the use of optical coherence tomography for detection of cells.
Abstract translation: 本文提供了使用光学相干断层摄影术来检测细胞的系统，方法和组合物。
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9.发明授权公开(公告)号：US09121690B2
公开(公告)日：2015-09-01
申请号：US14023197
申请日：2013-09-10
Inventor： Karthik Kumar , Jonathan C. Condit , Nathaniel J. Kemp , Thomas E. Milner , Xiaojing Zhang
CPC classification number: G02B3/12 , A61B5/0066 , A61B5/0084 , A61B5/6852 , A61B2562/0233 , A61B2562/028 , A61B2562/0285 , A61B2562/12 , B82Y20/00 , G01B9/02091 , G01B11/02 , G01B2290/65 , G01N21/4795 , G02B3/14 , G02B26/0833 , G02B26/105 , G02B2207/101 , G02B2207/109
Abstract: Provided are forward-imaging optical coherence tomography (OCT) systems and probes. In one embodiment, a scanning reflector surface is configured to be rotated about two axes in a single operating plane to direct light transmitted along the sample path to a sample to be imaged.
Abstract translation: 提供了前向成像光学相干断层扫描（OCT）系统和探针。 在一个实施例中，扫描反射器表面被配置为在单个操作平面中围绕两个轴线旋转，以将沿着采样路径传输的光引导到待成像的样品。
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公开(公告)号：US20150230709A1
公开(公告)日：2015-08-20
申请号：US14617560
申请日：2015-02-09
Inventor： Thomas E. Milner , Marc D. Feldman , Jung-Hwan Oh , Shaochen Chen , Paul Castella
CPC classification number: A61B5/0066 , A61B1/00183 , A61B1/3137 , A61B5/0084 , A61B5/6852 , A61B6/12 , A61B8/12 , A61B8/4461 , A61M25/0074 , A61M2202/0476 , A61N2007/0091
Abstract: The present invention relates to a rotating catheter tip for optical coherence tomography based on the use of an optical fiber that does not rotate, that is enclosed in a catheter, which has a tip rotates under the influence of a fluid drive system to redirect light from the fiber to a surrounding vessel and the light reflected or backscattered from the vessel back to the optical fiber.
Abstract translation: 本发明涉及一种用于光学相干断层摄影的旋转导管尖端，其基于使用不旋转的光纤，其被封装在导管中，该导管具有尖端在流体驱动系统的影响下旋转以使来自 光纤到周围的容器并且从容器反射或反向散射回到光纤的光。
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